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Biomedical subjects

P Turpeinen

Publications and source records attributed to P Turpeinen.

3 recordsLinked to original sources

Outcome of drug abuse in a 20-year follow-up study of drug-experimenting schoolchildren in Finland.

The fate of 119 drug-experimenting schoolchildren who had been interrogated by the narcotics police of Helsinki, Finland, during 1 year, 1971-72, was studied 20 years later. The material was divided in two groups: those with a favourable outcome (n=49) and those with a poor outcome (n=70). Nineteen had died. Criteria for poor outcome were death, prison sentence, psychiatric hospitalization, or continuation of crimes. The group with a favourable outcome was alive, did not have prison sentences or psychiatric hospitalizations, and had not been caught by the police after the initial phase of the study. Offences against property in early adolescence and intravenous drug use were predictive factors for imprisonment, psychiatric hospitalization, and death. A poor atmosphere at home and the occupation of the father as labourer were predictive factors for imprisonment, psychiatric hospitalization, and death for boys. For girls low education was predictive of imprisonment and psychiatric hospitalization. Drug use in adolescence is a signal of greater risk for adjustment problems in later life.

Adolescent↗

Lactose intolerance associated with fractures of weight-bearing bones in Finnish women aged 38-57 years.

Lactose intolerance (LI) often results in decreased calcium intake. To test if long-term low intake of calcium affects bone strength, we examined fracture risks related to LI in women aged 38-57 years. The 11,619 Finnish women aged 47-56 years who responded to the baseline postal inquiry of the Kuopio Osteoporosis Risk Factor and Prevention Study in 1989 formed the study population. In all, 896 women reported LI and 1299 women reported a fracture in 1980-1989. Current intake of dairy calcium was lower in women with LI (570 mg/d) than in the other women (850 mg/d) (p < 0.0001). The fracture risk in general was slightly elevated in women with LI compared with the other women, with an odds ratio (OR) (95% CI) of 1.33 (1.09-1.62). However, the fractures at the three most common sites (wrist, ankle, and rib) were not related to LI. In contrast, fractures at the tibia and metatarsal were strongly related to LI with ORs of 3.31 (1.51-7.24) and 2.84 (1.47-5.50), respectively. The adjusted OR for nonankle lower body fractures combined was 2.15 (1.53-3.04), whereas that for all upper body fractures combined was 1.15 (0.88-1.54). The 10 women with LI and a tibial or metatarsal fracture showed a 19% lower femoral BMD than all the other women in the densitometry subsample of 3222 women (p < 0.001). Long-term premenopausal calcium deficiency differentially affects bones with weight-bearing nonankle bones being at the greatest risk of suffering reduced strength.

Adult↗

Case study: mania associated with multiple sclerosis.

Mania occurs sometimes in association with an organic condition affecting the brain. A case of a 15-year-old girl with secondary mania related to multiple sclerosis is described, along with a selective review of the subject. The English-language literature published from 1986 to 1994 was reviewed, but geriatric and mentally retarded cases were excluded. This case points out that organic causes, often multifactorial, have to be kept in mind when treating patients who have mania.

Adolescent↗