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Biomedical subjects

P Toussaint

Publications and source records attributed to P Toussaint.

At least 37 records · Page 2Linked to original sources

[Surgical anatomy and surgical approaches of the third ventricle].

Careful analysis of MRI images is mandatory before any surgical procedure in the third ventricle. This analysis should take in account the relationship of the tumor itself, but also the grade of hydrocephalus and the main anatomical landmarks along the surgical approach. The first step is the access to the lateral ventricle, which may be achieved via transcortical or anterior transcallosal routes : these two operative procedures are detailed. The transforaminal entry to the third ventricle may be easy if hydrocephalus has widened the foramen of Monro. In other cases, a subchoroidal (or interthalamo-trigonal) approach is necessary, and the division of the thalamostriate vein is sometimes required. In this series, the transcortical route has been favoured by neurosurgeons. The advantages and drawbacks of both transcortical and anterior transcallosal routes are discussed. The anterior interhemispheric and pterional approaches are briefly evoked, as they were used in very few cases of this series. The management of hydrocephalus is discussed.

Humans↗

A CORBA-based integration of distributed electronic healthcare records using the synapses approach.

The ability to exchange in a meaningful, secure, and simple fashion relevant healthcare data about patients is seen as vital in the context of efficient and cost-effective shared or team-based care. The electronic healthcare record (EHCR) lies at the heart of this information exchange, and it follows that there is an urgent need to address the ability to share EHCR's or parts of records between carers and across distributed health information systems. This paper presents the Synapses approach to sharing based on a standardized shared record, the Federated Healthcare Record, which is implemented in an open and flexible manner using the Common Object Request Broker Architecture (CORBA). The architecture of the Federated Healthcare Record is based on the architecture proposed by the Technical Committee 251 of the European Committee for Standardization.

Medical Record Linkage↗

The federated healthcare record to support shared diabetes care.

In this paper the conception of the federated healthcare record server to support shared diabetes care is described. Business process modelling is applied to describe the shared care for diabetes patients. Typical dialogues between the different users (patient, internist, GPs, and diabetic nurses) are analysed and described in terms of use cases. Next to this modelling three incremental steps are defined to realise the record server based upon results of standardisation. It proves to be successful to design and build this record server on modern technologies like CORBA and JAVA.

Computer Communication Networks↗

Outcome in 43 patients with distal anterior cerebral artery aneurysms.

BACKGROUND AND PURPOSE: The aim of this retrospective multicenter study was to evaluate the outcome of distal anterior cerebral artery (DACA) aneurysms and to determine the incidence, causes, and consequences of unfavorable outcomes. METHODS: 43 patients with 50 DACA aneurysms (27 females and 16 males, mean age 49 years) were studied retrospectively. Forty-four DACA aneurysms were treated surgically (83% with an interhemispheric approach), and 2 were embolized. At postoperative day 10, all patients underwent routine angiography. The outcome at 6 to 12 months was scored according to the Glasgow Outcome Scale (GOS). RESULTS: 35 DACA aneurysms were ruptured. Among the 26 "good"-grade patients (Hunt and Hess grades I through III), 18 (69.2%) were in GOS 1, 2 in GOS 2 (7.7%), 2 in GOS 3 (7.7%), and 4 in GOS 5 (15.4%); among the 9 "poor"-grade patients (Hunt and Hess grades IV and V), 1 (11.1%) was in GOS 1, 2 in GOS 2 (22.2%), 2 in GOS 3 (22.2%), and 4 in GOS 5 (44.5%). The initial intracerebral hemorrhage (ICH) (40%) induced neurological aftereffects in 8 patients. An operative rupture occurred in 40%, with a temporary occlusion in 28.6% that was responsible for mediocre results in 3 patients (8.7%). A postoperative thrombosis was observed in 4 patients (11.4%) and an aneurysmal remnant in 1 (2.8%). Ten DACA unruptured aneurysms were clipped without operative rupture or thrombosis. CONCLUSIONS: The authors suggest that the proportion of ruptured DACA aneurysms evolving to a GOS 1 or 2 was similar to that of aneurysms found in other locations, after early surgery. Endovascular treatment should be considered in the management of uncommon ruptured fusiform DACA aneurysms.

Adolescent↗

[Intracranial meningioma in the elderly. Postoperative mortality, morbidity and quality of life in a series of 39 patients over 70 years of age].

UNLABELLED: The aim of this study was to assess the current morbidity and mortality in patients over 70 operated for intracranial meningioma. PATIENTS AND METHOD: We report a series of 39 consecutive patients (mean age: 73 y) operated for an intracranial meningioma over a period of 5 years (1990-1994). According to the Karnofski scale (KS), preoperative neurological status was inferior or equal to 70 in 21 patients (53.8%) and superior or equal to 80 in 18 (46.2%). All patients were followed up in order to precisely assess their post-operative condition and a computed tomographic scan (CT scan) was performed during the second semester of 1995 (mean follow-up 29 months). RESULTS: Operative mortality and permanent morbidity were respectively 7.6% and 10.3%. In 77% of this series, the KS score checked at the last follow up was 80 to 100 (good outcome). Poor outcome was defined by death or a postoperative (KS < or = 70, the principal cause being an hemorrhagic infarction. Three factors were predictors of poor outcome: poor preoperative neurological condition (KS < or = 70) (p = 0.07), location of the tumor on the base (p = 0.007), and the duration of surgery > 3 hours (p = 0.06). The logistical regression analysis showed that these three factors were independent. Tumor recurrence occurred in 5 (12.8%) of 39 patients. CONCLUSION: Preoperative KS is a prognosis factor, but a poor preoperative condition is not in itself a sufficient condition contraindicating surgery. The rates of operative mortality of 7.6%, and permanent operative morbidity of 10.3% can be given to patients and their families.

Aged↗

External fixation in war traumatology: report from the Rwandese war (October 1, 1990 to August 1, 1993)

Modern missiles cause important damage in the tissues. In case of bone injury, apart from the presence of foreign bodies and soil dirt in the foyer, the lesion is characterized by a certain instability caused by the smashing and resulting in the comminutive fractures, as well as severe lesions of the soft tissues. If primary treatment includes the necessity of a large wound excision, of which the modalities have been described for centuries, it also includes a rigorous immobilization of the foyer as precaution against shock and infection. All techniques proposed during former conflicts proved that they are little adapted to the final goal. Their inadequacy may lead to amputation, at any rate to severe sequelae. In war traumatology, opposed to the shortcomings of nonoperative methods and opposed to the prohibitions of intrafocal synthesis, external fixation is considered to be the best among compromises: it stabilizes fractures efficiently without risk, retains the distance between bone fragments, and prevents contracture of the muscles. External fixators promote debridement of the wounds, permit vascular repairs and control of the wounds, allow mobilization of the limbs, improve the injured's comfort, and facilitate evacuation . All types of external fixators can be used, but a number of military imperatives must be taken into account. Fixing of the device must be easy to every user, even with little training. A minimal number of parts must allow a maximal number of assemblies. Easy use implies simplicity, but the assembled set must be stable. It must reduce the reprise of reductions, its compression, and its distraction to a minimal number of acts. Moreover, it must be relatively cheap. In theory, all open war fractures should be treated by means of an external fixator. The problem, however of mass surgery under uncertain circumstances, the limited equipment, and a precarious supplying must be considered. Rwanda was involved in a war from October 1, 1990 to August 1, 1993 (Arusha's agreement). A Belgian medical team from the Military Cooperation had to cope with 4,646 different casualties. We treated 1,129 fractures, and among them 115 fractures of the arm, 122 fractures of the forearm, 80 fractures of the femur (including the neck and the condylae), and 148 fractures of the leg. We had to cope with 315 fractures of the hand, of which 220 fractures were of the metacarpal bone. "Strangely," there were always more lesions of the left hand (9.5%) than the right hand (5.8%), sometimes up to five times (the only exception was met in August 1993). We placed 209 external fixators (of which 20 bridging the joint in case of important impairment), including those used for an arthrodesis. In the majority fo the cases (93.3%), we used the French device Fixateur Externe du Service de Sante des Armees (FESSA). Until March 1993, we had no "orthopedic table." Since March 1988, we had an Image Intensifier, but not very appropriate to an operating room (no mobile C-arm). A more accurate one was lent by the Belgian Medical Service and set up in September 1992. The average time to place an external fixator was about 30 minutes. General practitioners were also trained to handle external fixators. According to the importance of mass casualties, an external fixator was used immediately upon arrival of the wounded or at revision day (5th day after debridement). The only exception were femoral fractures that were at first time-treated by traction for 10 days. Sometimes we had precarious supplying because the supplies had to be ordered in Europe. Sometimes one patient had to wait until material became available from another patient. External fixation was also used for reconstructive surgery, mainly for ankle arthrodesis. In conclusion, it was possible for a very small surgical team, on its own for 18 months, to cope with a lot of difficulties caused by lack of readiness of the Rwandan Armed Forces, lack of organization, and lack of discipline of the R

External Fixators↗

Central effects of 5-HT on respiratory and hypoglossal activities in the adult cat.

The activities of the diaphragmatic, internal intercostal and hypoglossal-innervated muscles were studied in adult decerebrate cats in response to 5-HT and related agents (8-OH-DPAT and DOI). The drugs were placed on the floor of the IVth ventricle. The mean respiratory frequency (Fi) increased (124-193% of the control value) within 3 min of the 5-HT application, and decreased thereafter (30-90%). The mean Ti and Te changed similarly, but opposite to Fi. With some delay, the hypoglossal-innervated muscles were tonically activated or exhibited increased activities. Methysergide pretreatment completely blocked the effect of 5-HT on all the respiratory parameters and the hypoglossal-innervated muscles activities. The responses to 8-OH-DPAT and DOI indicate that 5-HT modulates the respiratory frequency via activation of both 5-HT1A and 5-HT2 receptors. Nevertheless, the effect of 5-HT on both the expiratory and hypoglossal-innervated muscles seems to depend on 5-HT2 receptors activation only.

Animals↗

Nonvagal reflex apnea in the newborn kitten and during the early postnatal period.

The aim of this work was to study the nonvagal mechanisms which might induce apneic reflexes in kittens. Experiments were performed on spontaneously breathing animals (19 kittens at different postnatal ages). Animals were anesthetized (halothane) or decerebrated by transcollicular section of the brainstem. Weakly nociceptive cutaneous stimulations and various oral stimulations were administered in all animals. In 10 kittens, one of the lingual nerves was stimulated electrically. In 3 decerebrate kittens the effects of serotonin on respiratory activity and on muscles innervated by the hypoglossal nerve were studied. All the stimulations produced apneas of variable duration, and expiratory reinforcement was associated with activation of pretracheal muscles. Similar effects were observed after applying serotonin to the floor of the 4th ventricle. Thus serotonin may be involved in the mechanisms that cause some apneas.

Anesthesia↗

Hepatic flow scintigraphy in evaluation of hepatic metastases in patients with gastrointestinal malignancy.

OBJECTIVE: To assess the value of hepatic flow scintigraphy for occult metastases. DESIGN: Prospective study, 2 years of follow-up. SETTING AND STUDY PARTICIPANTS: One hundred twenty-nine patients undergoing surgery for gastrointestinal cancer. INTERVENTION: Preoperative hepatic flow scintigraphy (3mCi of technetium-99m). MAIN OUTCOME MEASURE: Development of hepatic metastases. RESULTS: Hepatic flow scintigraphy had a sensitivity of 92% and a specificity of 34%. The positive and negative predictive values were 15% and 97%, respectively. CONCLUSIONS: Hepatic flow scintigraphy could therefore be useful in identifying patients who are at low risk of developing metachronous liver metastases and thus avoid unnecessary adjuvant chemotherapy following resection of the primary tumor.

Female↗

[Creation of a planned autologous transfusion unit in a hospital distinct from a transfusion center].

Autologous blood predonation now widely used for programmed surgery has been recently regulated by a law from january 9 1992. It establishes that the procedure must be performed under the responsibility of an accredited blood transfusion center. This work discloses that the establishment of an autotransfusion unit in a hospital endowed with an active surgical program is feasible, the major objective being improvement of the quality of life of elderly patients with invalidating diseases. We report the one year experience of a collaboration between the Braine-l'Alleud-Waterloo hospital and the Red Cross Erasme-Brabant Wallon blood transfusion center. Eighty patients enrolled in programmed surgery consisting mostly in orthopedic surgery have given 187 units of packed red blood cells and fresh frozen plasma. Sixty two patients (83%) were transfused solely with autologous blood. Tolerance was excellent as only 4 slight malaise episodes were observed. Our study also indicates that programmed predonation should be proposed mainly to patients for whom the prescribed blood is effectively transfused. Creation of such autotransfusion units in hospitals distinct from a blood transfusion center is feasible with the deep collaboration between physicians in charge of the patients, the hospital laboratory and the blood transfusion center.

Adult↗

[Preoperative autotransfusion for elective surgery].

In order to eliminate the risk of transmission of infectious diseases and of alloimmunisation, a pre-deposited autologous blood program for elective surgery has been started at the Erasmus Hospital. In 8 months, 51 patients have given 111 units of packed red cells and 111 units of fresh plasma. Two vasovagal reactions were observed. Four patients were withdrawn from the program in view of a hematocrit decreasing below 34%. Out of these 51 patients, 27 (53%) were transfused with only autologous blood. The autologous blood not distributed to these patients was given to other patients (10% of packed red cells and 24% of plasma). This pre-deposited autologous program has allowed to operate more than 50% of patients, undergoing elective surgery, only with autologous blood and to save homologous blood. The pre-deposited blood appears to be an interesting tool in transfusion safety and in the reduction of blood demand.

Blood Preservation↗

[Aspects of the tilted disk syndrome].

4 cases of tilted disc syndrome are reported. Two were associated with sellar or endocrine pathology, one had a particular aspect of chorioretinal atrophy, and the last had a thrombosis of the central vein of retina. The most commonly aspects of tilted disc syndrome are reported.

Adult↗

[Descending ocular myopathy--apropos of a case].

Descending ocular myopathy is a rare progressive disease characterized by bilateral ptosis, external ophthalmoplegia and progressive dystrophy of the proximal skeletal muscles. A case of descending ocular myopathy with post-operative corneal ulceration is reported. Mitochondrial abnormalities are found on skeletal muscle biopsy. Nosologic classification of this case is discussed.

Adult↗