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Biomedical subjects

P Touré

Publications and source records attributed to P Touré.

At least 19 recordsLinked to original sources
PubMed2006

Evaluation of adenovirus vectors containing serotype 35 fibers for tumor targeting.

There is growing evidence from in vitro studies that subgroup B adenoviruses (Ad) can overcome the limitations in safety and tumor transduction efficiency seen with commonly used subgroup C serotype 5-based vectors. In this study, we confirm that the expression level of the B-group Ad receptor, CD46, correlates with the grade of malignancy of cervical cancer in situ. We also demonstrate the in vivo properties of Ad5-based vectors that contain the B-group Ad serotype 35 fiber (Ad5/35) in transgenic mice that express CD46 in a pattern and at a level similar to humans. Upon intravenous and intraperitoneal injection, an Ad5/35 vector did not efficiently transduce normal tissue, but was able to target metastatic or intraperitoneal tumors that express CD46 at levels comparable to human tumors. When an oncolytic Ad5/35-based vector was employed, in both tumor models antitumor effects were observed. Furthermore, injection of Ad5/35 vectors into CD46 transgenic mice caused less innate toxicity than Ad5 vectors. Our data demonstrate that Ad vectors that target CD46 offer advantages over Ad5-based vectors for treatment of cancer.

Adenoviridae↗
PubMed2001

HLA class II DR-DQ and increased risk of cervical cancer among Senegalese women.

To examine Senegalese women to confirm and extend associations between HLA class II types and cervical cancer previously observed among African-American, Caucasian, Hispanic, and Japanese ethnic populations, 55 Senegalese women with invasive cervical carcinoma were compared with age-matched (human papillomavirus) HPV-positive (n = 83) and HPV-negative (n = 107) control women. PCR-based HPV and HLA typing methods were used. Data were analyzed using a global randomization test and conditional logistic regression. Although this study failed to confirm a previously reported association between cervical cancer and DQB1*03 alleles, the DRB1*1101-DQB1*0301 haplotype was detected more frequently among cervical carcinoma cases than among controls (adjusted odds ratio, 2.6; 95% confidence interval, 1.0-7.1). Furthermore, as reported by others, we observed a negative association of borderline statistical significance between DRB1*13 and cervical carcinoma (adjusted odds ratio, 0.5; 95% confidence interval, 0.2-1.1). Observations from this study confirm earlier findings of a negative association between DRB1*13 and cervical cancer and suggest that specific DRB1-DQB1 haplotype combinations, rather than individual DQB1*03 alleles, increase the risk for cervical cancer.

Adult↗
PubMed1984

[Epidemiology of primary cancer of the liver in Senegal].

Hepatocellular carcinoma is the most common malignant tumour in Senegal, the incidence being estimated at 22.3 per 100 000 among men and 8.3 per 100 000 among women. This estimate was made on the basis of a series of 228 cases registered between 1969 and 1971 at the Pathological Anatomy Laboratories in Dakar. The ethnic distribution of these cases indicates a clear predominance among Sudano-Sahelian groups (Wolofs and Sérers) in comparison with groups of mixed race (Peulhs) or of Berber origin (Moors). This difference holds true even when the different ethnic groups live in the same region, as in the valley of the Senegal River. An epidemiological study indicates a hepatitis viral etiology. The prevention of hepatitis B is described and the results given of a vaccination programme in Senegal.

Age Factors↗
PubMed1984

[Cytological detection of lesions of the uterine cervix: results of a campaign in Senegal].

The authors have analysed the results of 5131 Papanicolaou tests carried out in Senegal between November 1980 and July 1983. They emphasize the importance of classes II and III, which correspond to lesions that can be treated so as to ensure prevention of cervical cancer. The classical etiopathogenic factors of this type of cancer are studied, and results obtained from a group tested systematically are compared with those of a group that were tested only at the time of a gynaecological examination for another purpose. This comparison demonstrated the usefulness of systematic screening. The authors propose a scheme for organizing the prevention and screening of this type of cancer at the subregional level in Africa.

Adolescent↗