Search PubMed⌕ Search

Biomedical subjects

P Thune

Publications and source records attributed to P Thune.

At least 91 records · Page 5Linked to original sources
PubMed1977

Contact allergy due to lichens in patients with a history of photosensitivity.

Ten patients with a history of photosensitivity and of a rash showed abnormal reactions to long-wave UVR. The rash occurred particularly in areas exposed to light, though other areas were occasionally involved. The development of the rash could in all patients be related to contact with lichens and although exposure to sunlight usually led to an aggravation of symptoms, some patients, particularly forestry workers, showed exacerbations even during the winter. Positive responses were observed in both irradiated and non-irradiated patch tests with different species of lichen and in several patients irradiation precipitated a stronger response. These findings suggest that lichens can cause both contact and photocontact dermatitis. The suspected allergens contained in these lichens are atranorin, physodalic and pysodic acids.

Adult↗
PubMed1977

Photochemotherapy of psoriasis with relevance to 8-methoxypsoralen plasma level and low intensity irradiation.

The 8-methoxypsoralen (8-MOP) plasma level was determined in 31 patients during treatment with PUVA (psoralen + UVA light). The UVA light source was of a low intensity type, giving only 2 mW/sec/cm2 and required an irradiation time of 30 minutes. The lesions of 19 patients healed completely. Following an oral dose regimen adjusted to the patient's weight, the 8-MOP values at 2 hours varied from 2 ng/ml to 167 ng/ml (mean 56 ng/ml). There was no clearcut relation between the 8-MOP plasma level and the clinical response but in 9 patients there was a prompt response to treatment when the dose of psoralen was increased by 10 mg. In 5 patients the 8-MOP plasma levels was determined hourly for the first 4 hours and showed a peak at 2 hours except in one patient with very low values who had a peak at 4 hours. The augmentation of pigmentation was measured by means of reflectometry on three univolved areas. Two peaks were observed--one during the first week and the other after 2--3 weeks of therapy.

Adult↗
PubMed1976

The relationship between the course of psoriasis and transepidermal water loss, photoelectric plethysmography and reflex photometry.

The transepidermal water loss (TWL), photoelectric plethysmography and reflex photometry were parallelly registered on the involved hands and forearms of psoriatics. The TWL values showed a fairly good correlation with the clinical course of the disease: they increased during the active phase and decreased after return to normal. The vascular tests did not show a strict parallelism with the clinical state. On the basis of the findings, the temporal relations between epidermal and vascular factors during the different phases of the psoriatic process are discussed. The TWL can be used to predict a relapse occurring on the area investigated but not on a distant area.

Erythema↗
PubMed1976

Chronic polymorphic light eruption. Particular wavebands and the effect of carotene therapy.

Forty patients with chronic polymorphic light eruption (CPLE) were tested with the Osram High Pressure Xenon (XBO 150 W) lamp. The tests were performed with unfiltered light, with the Schott WG320 filter for wavelengths above 320 nm and with Schott filters for 310 nm and 361 nm. Abnormal reactions, i.e. lowered MED, papular response or reactions to long wave UV light were observed in almost all patients. A papular response was obtained in more than 50%. With a Schott KG1 filter, which particularly reduces the amount of infrared radiation, there was a great reduction in number of responses. The effect of carotene therapy was evaluated in 17 patients. The therapy had a beneficial effect of low significance only in the case of unfiltered light and not for any particular waveband. Some patients showed clearly an increase in tolerance to sunlight, but this was not related to the plasma level of carotene.

Adolescent↗
PubMed1976

The cutaneous reactions to kallikrein, prostaglandin and thurfyl nicotinate in chronic urticaria and the effect of polyphloretin phosphate.

The erythema and wealing resulting from the application of thurfyl nicotinate ointment (Trafuril) and from the inoculation of kallikrein has been studied in patients with chronic urticaria and normal controls. Polyphloretin phosphate (PPP) suppressed the reaction in controls but in patients with urticaria it increased the reactions to Trafuril and had little effect on the kallikrein reaction. PPP also suppressed the PGE2-induced erythma in normal controls but not in urticaria patients. In a separate study using fibrinolysis autography, prostaglandin (PG) E2 and PGF2alpha depressed fibrinolysis in the skin of two pigs and both kallikrein and Trafuril suppressed fibrinolysis in human skin. It is suggested that the inflammatory reaction induced by thurfyl nicotinate and kallikrein is mediated in part by a prostaglandin-like action. Several anomalies in the action of Trafuril in skin diseases can be explained if such prostaglandin-like activity is mediated in part through inhibition of fibrinolysis.

Chronic Disease↗
PubMed1975

Effects of adrenergic stimulating and blocking agents on the eccrine sweat secretion in atopic dermatitis and psoriasis.

Quantitative measurements of eccrine sweat secretion following stimulation with adrenaline and terbutaline sulphate, a beta-stimulator, have been performed in patients with atopic dermatitis and psoriasis by means of the electrolytic water analyzer, "Meeco". Seasonal variations were demonstrated, the values being lower in the late autumn. The response to adrenaline could be blocked by phentolamine, an alpha-inhibitor, while propranolol, a beta inhibitor, had no effect.--The response to terbutaline was blocked by atropine and partly by practolol, a beta-inhibitor. Terbutaline induced a larger sweat response than isoprenaline, another beta-stimulator. A beta-receptor mechanism, in some way related to cholinergic receptors, is suggested.

Adrenergic Agonists↗
PubMed1975

Provocation tests with antiphlogistica and food additives in recurrent urticaria.

100 patients (53 women, 47 men) suffering from recurrent urticaria were tested with different food additives such as 8 dye additives, 7 preservatives and 7 antiphlogistica. In total did 62 patients react with urticaria and/or angio-oedema. 39 patients had reactions to two or more substances while 23 patients reacted to only one substance. Reactions were induced most frequently by aspirin (27/80), dextropropoxyphene (11/45) and the azo dyes tartrazin (20/96) and sunset yellow (13/86/. Asthmatic symptoms occurred in 3 and purpura in 2 patients. 13 patients out of 100 reported of immediate reactions to different foods.

Adolescent↗
PubMed1975

Gastrointestinal investigations in dermatitis herpetiformis.

Thirty-seven patients with dermatitis herpetiformis (DH) have been investigated for gastric and small intestinal abnormalities. Evidence of an enteropathy was found in 86% of the patients who had IgA deposits in uninvolved skin. Villous atrophy of the small intestine was found in 29 patients. About one-half of the patients had reduced absorption of xylose and vitamin A. The Schilling test value was lowered in one-third. Serum B12 was too low in 5/28 patients whereas folic acid in serum and whole blood was too low in 14/29 and 5/19, respectively. Atrophic gastritis occurred in 14/28 patients and only about one-third of the whole patient material had normal gastric mucosal structure and secretion.

Adolescent↗