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Biomedical subjects

P Thompson

Publications and source records attributed to P Thompson.

At least 289 records · Page 16Linked to original sources
PubMed1977

Intramuscular salbutamol in treatment of acute exacerbations of childhood asthma.

Salbutamol was given by the intramuscular route to children aged 3 to 16 years with an attack of asthma. Results with a dose of 8 microgram/kg were favourable but suggested that a higher dose might be more so. 16 children thereafter were treated with 20 microgram/kg which produced a greater mean increase in peak expiratory flow rates (PEFR) without increase in side effects. This dose was then used in a double-blind crossover trial of salbutamol against a saline placebo. Half of 36 children treated with 20 microgram/kg showed rapid clinical improvement, the maximum rise in PEFR occurring within the first 5 minutes. A rise in pulse rate and occasionally a tremor were the only side effects noted. We conclude that intramuscular salbutamol 20 microgram/kg is a safe and useful initial medication in the management of the asthmatic child suffering an acute exacerbation.

Acute Disease↗
PubMed1977

Epileptiform syndrome in rats produced by injecting tetanus toxin into the hippocampus.

An epileptiform syndrome in rats produced by injecting small doses (a few (mouse)LD50) of tetanus toxin into the hippocampus is described. The animals had intermittent seizures, with at least a superficial resemblance to human epilepsy, for some weeks but they eventually recovered. They were hyperkinetic for several weeks after the injection of toxin, and showed intermittent aggressive behaviour. Control animals which received similar injections of tetanus toxin first neutralised with antitoxin did not have seizures, and their behaviour appeared normal. EEG recordings showed characteristic seizure activity. Histological examination of the site of injection showed very little morphological damage.

Animals↗
PubMed1977

Effect of dialysis on hearing acuity.

In order to determine the effect of dialysis on hearing acuity, 20 patients on chronic maintenance hemodialysis or peritoneal were followed with hearing examinations every 6 months over a follow-up period of 1-4 years. While 70% of the study group had some measureable hearing loss at the beginning of the study, 75% of the patients showed no deterioration of hearing loss during the follow-up period. It is suggested that hearing deficits in chronic renal failure are common and multifactorial in etiology, and that most patients undergoing chronic dialysis show no further deterioration in hearing acuity.

Adolescent↗
PubMed1976

Arthritis.

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Arthritis↗
PubMed1975

Apparent motion and the Pulfrich effect.

The Pulfrich pendulum effect, obtained by viewing a moving object with a filter over one eye, was examined with target stimuli in apparent, rather than continuous, motion. The filter-induced depth effect persisted until a certain degree of intermittency in the presentations of the target was reached, and then it broke down. The degree of intermittency that could be tolerated before the depth effect broke down increased with the density of the filter. It could be argued that the filter determined a shift in the pairing of successive inputs to the eyes, such that the target position in the unfiltered eye was fused with the preceding target position in the filtered eye. However, it appears that the shifted-pairing effect cannot account for the depth impression seen when the target intermittency is less than about 30 ms. Below this value of intermittency a filter can produce a depth effect even when the delay it introduces is small in comparison to the intermittency of the input. The depth effect seen with intermittencies less than 30 ms appears to be of the same magnitude as that obtained with stimuli in continuous motion. It is concluded that a filter can cause two different kinds of depth shift with apparently moving stimuli.

Depth Perception↗
PubMed1975

Development and evaluation of a training program for volunteers working in day treatment.

When staff members of a community mental health center's day treatment program for adults with emotional problems found there was not enough time for planning and meeting program goals, they considered using volunteers to help in the treatment process. The center staff worked with the local mental health association to plan the training and use of volunteers. Twenty-five volunteers were initially selected and trained. They evaluated the training through questionnaires immediately after training and after three and six months of service. Respondents felt the training prepared them to perform their duties and understand their roles as volunteers. Volunteers have worked in the program for two and a half years; currently 28 volunteers each work approximately three hours a week.

Adult↗
PubMed1971

Sudden death in hospital after discharge from coronary care unit.

In a group of 339 patients with acute myocardial infarction treated in a coronary care unit, 273 left the unit while improving and were expected to leave hospital alive; 23 had a cardiac arrest or died suddenly while still in hospital-17 died immediately or after temporary resuscitation and six were resuscitated to leave hospital alive. Ventricular fibrillation was found in 13 of the 20 patients attended by the cardiac arrest team. The incidents were scattered from the 4th to the 24th day after the onset of infarction. Risk factors in these "late sudden death" patients were compared with the 250 patients who left the unit while improving and did not die or suffer cardiac arrest. The patients susceptible to late sudden death were characterized early in their hospital course by the findings of severe, predominantly anterior infarction, left ventricular failure, persistent sinus tachycardia, and frequent ventricular arrhythmias. It is suggested that such patients be chosen for prolonged observation in a second-stage coronary care unit.

Acute Disease↗
PubMed1970

Long-range planning.

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Hospital Administration↗
PubMed1970

Familial pulmonary hypertension. Evidence of autosomal dominant inheritance.

A patient with primary pulmonary hypertension is the fourth member of a family proven to have the disease. The patient's father married twice; the disease appeared in both families, and was transmitted through two generations. Multiple genetic and environmental factors may result in pulmonary hypertension, but the distribution of cases in this family and in others reported is consistent with the autosomal dominant inheritance of a single genetic trait.

Genes, Dominant↗