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Biomedical subjects

P Tetsch

Publications and source records attributed to P Tetsch.

At least 55 records · Page 3Linked to original sources
PubMed1981

Effects of cloxazolam and pindolol on the sympathetic and adrenal stress reaction during oral surgery in man.

In two studies including 73 patients the stress reducing effects of the tranquilizer Cloxazolam (Olcadil) and the beta-receptor-blocking drug pindolol (Visken) were investigated after the application of a single oral dose (3 mg Cloxazolam, 5 mg pindolol). The drugs were tested against placebo by the double blind method. After local anesthesia and during oral surgery an increase of dopamine-beta-hydroxylase (DBH)-activity, noradrenaline-, c-AMP-, ACTH and cortisol concentration was found in the placebo group. Cloxazolam antagonized all these effects, except the increase of the plasma levels of c-GMP under surgical stress. After pindolol noradrenaline concentration, DBH-activity, and c-AMP concentration were no longer increased during oral surgery. But the hypothalamic and adrenal stimulation were still present and resulted in an unchanged stress reaction of ACTH and cortisol concentration in plasma. In conclusion, the application of the beta-receptor-blocking drug pindolol prevents the stimulation of the sympathetic nervous system by suppressing the stress induced increase of plasma system by suppressing the stress induced increase of plasma noradrenaline and by blockade of peripheral beta-receptor sites. Cloxazolam reduces hypothalamic and adrenal reaction as well as peripheral ones due to stress.

Adrenal Glands↗
PubMed1981

Investigations on recurrent condyle dislocation in patients with temporomandibular joint dysfunction: a therapeutical concept.

In the last 2 years, 30 patients with recurrent condyle dislocation were examined and treated with two different two-phase procedures according to their main clinical symptoms. The success of both procedures, firstly, pericapsular injection of homogenous blood and, if necessary, elimination of occlusal disharmonies, and secondly, functional treatment with occlusal adjustment, in some cases followed by injection therapy, is outlined. Some suspected etiological factors are investigated. In 14 out of 19 patients in Group I injections were successful, three cases improved, and therapy failed in two patients during a follow-up of up to 18 months. Four out of eleven patients treated in Group II with occlusal adjustment first had total relief of symptoms, three improved, and four showed no significant improvement during a mean follow-up of 5 months. Our beneficial results in Group I justify the procedure described here as a valuable alternative to more aggressive approaches and should be the initial modality of choice in this condition.

Adult↗
PubMed1980

[Clinical study on stress protective action of cloxazolam in jaw surgery in double blind comparison to placebo (author's transl)].

An investigation in 50 patients has shown that biochemical measurements of dopamine-beta-hydroxylase (DBH), ACTH and cortisol as well as the concentration of glucose and insulin signal a reduction of surgical stress under the medication of the tranquilizer 10-chloro-11b-(2-chlorophenyl)-2,3,5,6,7,11b-hexahydrobenzo[6,7]-1,4-diazepino[5,4-b]oxazol-6-one (cloxazolam, MT 14-411). There was an inhibition of the DBH-increase during the surgical procedure and an inhibition of the ACTH- and cortisol-secretion before and during surgery as well as a reduction of the insulin antagonizing effect during sympathicoadrenal stimulation. With the exception of a sedative action no other side effects have been observed.

Adolescent↗
PubMed1980

[Regeneration in bony defects after implantation of resorbable calcium phosphate ceramics. A comparative clinical study].

After experimental demonstration of the excellent tissue tolerance with ceramics-bone contact without connective tissue in animals and because of the good resorbability of tri-calcium phosphate ceramics (TPC), TPC ceramics was used in a clinical study to fill the bony defects resulting from apicectomies and cystectomies. The patients were controlled for a period of up to six months. After an initially normal healing phase, an unusually high rate of late complications with fistula formation and rejection of the TPC ceramics was observed around the tenth postoperative week. Possible causes for these late complications were discussed.

Apicoectomy↗