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Biomedical subjects

P Tanner

Publications and source records attributed to P Tanner.

24 records · Page 2Linked to original sources
PubMedDate not supplied

High density lipoprotein cholesterol in haemorrhagic hyperlipidaemia in rabbits.

The effects of repeated bleeding (15 ml/day/kg b.wt. on 3 consecutive days) on plasma lipids, especially on high density lipoprotein (HDL)-cholesterol were studied in rabbits. As a result of the bleeding, plasma triglycerides (TG) increased from a mean of 0.61 (SD range 0.34-1.09) mmol/l to 2.86 (1.16-7.12) mmol/l (P less than 0.02). Plasma total cholesterol (TC) increased from 1.4 +/- 0.5 (SD) mmol/l to 2.0 +/- 0.5 mmol/l. The concentration of HDL-cholesterol, however, decreased from 0.72 +/- 0.16 mmol/l to 0.48 +/- 0.23 mmol/l (P less than 0.02). The HDL-cholesterol/TC ratio decreased from 0.57 +/- 0.17 to 0.29 +/- 0.15 (P less than 0.05). In connection with the haemorrhagic hyperlipidaemia a negative correlation (P less than 0.01) appeared between plasma TG and HDL-cholesterol. It is concluded that hypoxia, being the primary cause of haemorrhagic hyperlipidaemia, may be one factor regulating HDL-cholesterol concentrations and thereby possibly the development of atherosclerosis.

Animals↗
PubMedDate not supplied

Effect of immune complexes on plasma HDL-cholesterol in rabbits.

The effect of immune complexes on plasma lipids, especially on high density lipoprotein (HDL) cholesterol, was studied in rabbits. In rabbits immunized twice with bovine serum albumin (BSA) with an interval of about 6 weeks, a significant decrease in plasma HDL-cholesterol (P less than 0.01) and in the HDL/total cholesterol ratio (P less than 0.02) was found 6 days after the second BSA injection. As a result of repeated bleedings commenced 6 days after the second BSA injection, the changes in plasma triglycerides (TG) and total cholesterol (TC) were similar to those found previously in non-immunized rabbits. In contrast to the findings in non-immunized rabbits, no significant decrease in HDL-cholesterol was found as a consequence of the bleedings, but a negative correlation (P less than 0.05) between plasma TG and HDL-cholesterol appeared. It is concluded that immune complexes may affect plasma HDL-cholesterol concentrations and thereby possibly also the development of atherosclerosis.

Animals↗
PubMedDate not supplied

Serum gonadotropins and testosterone in men occupationally exposed to carbon disulfide.

Serum levels of gonadotropins and testosterone were determined for 69 men exposed to CS2 in viscose rayon production and for 22 nonexposed male controls. Mean ages of the two groups were 40 and 39 yr, respectively. The duration of exposure to CS2 ranged from 1 to 36 yr (mean, 12.5). Follicle stimulating hormone (FSH) levels were significantly higher among the exposed men than among the controls (13.6 versus 10.0 IU/l). The level of sex hormone binding globulin (SHBG) was significantly lower among the exposed men than among the controls (44 versus 53 nmol/l). Luteinizing hormone (LH) values were significantly higher among the 24-31 yr old exposed men than the controls of the same age. Levels of SHBG, of the free testosterone index, and of FSH and LH in men under 39 yr who had been exposed to CS2 for 1-9 yr differed significantly from those of their controls, whereas only FSH differed significantly among those exposed for 10 or more years in the same age group. In men aged 40 yr or more, after at least 10 yr of exposure, only FSH and LH were significantly higher than in the controls. Although the observed alterations do not seem to have any overt clinical implications for the study groups, they indicate that overall levels of CS2 that are well below the current Finnish threshold limit value (30 mg/m3) may affect the hormonal balance in the pituitary-gonadal axis, favoring the view that there may be an increased risk of latent primary gonadal insufficiency.

Adult↗