Biomedical subjects
Publications and source records attributed to P Talard.
The authors report a case of angiosarcoma of the descending thoracic aorta presenting with a metastasis of the small intestine. This is a very rare tumour in this localisation, two cases having been described among the 28 cases of aortic tumour reported in the literature.
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These two cases concern myocardial infarcts where the electrocardiogram (ECG) was within normal limits at admission and throughout the period of hospitalisation, the diagnosis of an infarct being made secondarily on the basis of raised CPK. Both cases involved infarcts limited to the lateral wall due to occlusion of the first marginal artery of the left border. Several recent studies have evaluated the diagnostic value of the ECG in infarcts and have shown its lack of sensitivity in lateral infarcts. The resultant diagnostic difficulties may lead to delayed treatment, the consequences of which should not be capital since it has been shown that infarcts with a normal or minimally abnormal ECG at the time of admission have a favourable short term prognosis.
The aim of this study was to assess the value of a non-invasive test in detecting accessory pathways with short anterograde effective refractory periods (AERP) (less than or equal to 270 ms) in patients with the Wolff-Parkinson-White syndrome. An intravenous injection of Flecainide acetate was administered to 19 consecutive patients referred for electrophysiological investigation of a WPW syndrome with permanent pre-excitation of the surface electrocardiogram. The first 8 patients (Group I) received a dose of 1.5 mg/kg over 5 minutes and the following 11 patients (Group II) were given 2 mg/kg in 5 minutes. In Group I, preexcitation disappeared in 3 patients (37.5%) who all had accessory pathways with AERP greater than 270 ms. It persisted in the other 5 patients (62.5%) of whom 4 had AERP less than or equal to 270 ms and 1 an AERP greater than 270 ms (false negative). In Group II, preexcitation disappeared in 8 patients (72.2%) of whom 4 had AERP greater than 270 ms and 4 had AERP less than 270 ms (false positives). Preexcitation persisted in the 3 other patients (27.3%); the AERP was less than or equal to 270 ms in 2 patients and greater than 270 ms in the other patients. These results suggest that intravenous Flecainide acetate at the dose of 1.5 mg/kg could be useful in differentiating WPW syndromes with long refractory periods (greater than 270 ms) from those with short refractory periods (less than or equal to 270 ms) with a satisfactory sensitivity and specificity, and that further studies on larger numbers of patients are required to confirm this hypothesis.
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Ultrafiltration, a method of extra renal filtering, which accomplishes an iso-osmotic removal of water an sodium from the plasma, was used in twelve patients. It is reserved for terminal persistent heart failures. In one case, it preceded a heart transplant. Simple to carry out, this technique is well tolerated when the pulmonary pressure is elevated, respecting an ultrafiltration output inferior or equal to 500 ml/h. Immediate improvement of the patients is spectacular. A new treatment failure may impose long-term ultrafiltration sessions. Failure of the medical treatment, impossibility of heart transplant, must be an indication for ultrafiltration which improves the comfort, and most likely the life expectancy of patients with persistent heart failure.
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