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P T Valente

Publications and source records attributed to P T Valente.

16 recordsLinked to original sources
PubMed1992

Peritoneal cytology of uncommon ovarian tumors.

Peritoneal cytology has been well established as a diagnostic and staging tool in the management of the common epithelial tumors of ovary. Germ cell, mesenchymal, and sex-cord stromal tumors are much less frequently encountered in peritoneal specimens, often with cytologic features that may pose problems in differential diagnosis. This report presents the cytomorphology of the ascitic fluid in cases of endodermal sinus tumor, dysgerminoma, and Sertoli-Leydig-cell tumor, and peritoneal washings in a case of ovarian malignant mixed mullerian tumor. The cytologic features of Sertoli-Leydig-cell tumors have not been well described. Careful correlation of peritoneal cytologic findings, cell-block preparations, and immunocytochemistry with the cytohistologic features of these tumors is crucial for correct tumor classification.

Adolescent↗
PubMed1991

The determination of Papanicolaou smear adequacy using a semiquantitative method to evaluate cellularity.

To examine the influence of sample cellularity and the presence of endocervical columnar cells on the detection of cervical dysplasia, Papanicolaou (Pap) smears taken from patients with biopsy-proven CIN II and III were analyzed retrospectively. Adequacy was semiquantitated by dividing each smear into 15 equal areas using a lined template and assigning an adequacy index (AI) of 0 to 15. The total false-negative (FN) rate was 15.8 percent, with 6.1% representing interpretive error and 9.7% representing sampling error. For FN slides truly lacking abnormal cells, the average AI was significantly lower than that of true positives (TP), even when endocervical columnar cells were present. The entire group was then blindly re-evaluated using a subjective application of the Bethesda System, classifying slides as satisfactory, less than optimal, and unsatisfactory. Although correlation of AI with the rapid Bethesda System categorization was imperfect, the exclusion of less than optimal and unsatisfactory smears also lowered the FN rate, but less effectively. An AI scoring technique, therefore, may be useful in the routine evaluation of Pap smear adequacy.

Carcinoma, Squamous Cell↗
PubMed1991

Extrauterine mixed mesodermal tumors. An immunohistochemical study.

Mixed mesodermal tumors are uncommon outside the uterus. Nine extrauterine mixed mesodermal tumors (eight ovarian and one extragenital) were selected for histochemical and immunoperoxidase study. In eight cases, both epithelial and mesenchymal elements were malignant (chondroid in six, rhabdomyoid in four, and osteoid in two). One ovarian tumor was an adenosarcoma. All cases were stained with periodic acid-Schiff with and without diastase and for alpha 1-antitrypsin, myoglobin, keratin, vimentin, muscle-specific actin, and alpha 1-antichymotrypsin, by using the avidin-biotin-immunoperoxidase method. The periodic acid-Schiff-positive, diastase-resistant droplets in several of the tumors showed peripheral alpha 1-antitrypsin positivity. Keratin delineated epithelial areas well in seven cases, and rhabdomyoid differentiation was confirmed with myoglobin in four cases. However, squamous elements in one tumor were falsely positive for myoglobin. We concluded that despite occasional cross-reactivity, carefully interpreted immunoperoxidase stains can be useful in distinguishing epithelial and mesenchymal elements in these tumors.

Female↗
PubMed1991

Human papillomavirus--associated vulvar verrucous carcinoma in a 20-year-old with an intact hymen. A case report.

A 20-year-old woman with vulvar verrucous carcinoma, the youngest such patient reported to date, had human papillomavirus DNA 6/11 identified with an in situ hybridization technique. In addition to her youth, the patient was unusual in that she had an intact hymen. Although she denied having engaged in sexual activity, venereal transmission of the virus may have occurred without vaginal penetration.

Adult↗
PubMed1990

Postabortal hemorrhage due to placenta increta: a case report.

Placenta accreta is defined as a condition involving an abnormal adherence of the placenta to the myometrium. It is rare for placenta accreta to present before 20 weeks' gestation; only eight cases have been previously reported. This case report describes a first-trimester placenta accreta which presented during suction curettage for missed abortion. The major risk factors for placenta accreta are related to previous uterine trauma. Considering the rising rate of operative births in the United States, it is possible that the incidence of placenta accreta in early gestation will increase.

Abortion, Missed↗
PubMed1987

Cervical adenocarcinoma arising in florid mesonephric hyperplasia: report of a case with immunocytochemical studies.

A case of mesonephric adenocarcinoma of the uterine cervix arising in florid mesonephric hyperplasia is reported. The reviewed literature contained many cases of cervical "mesonephroma" but only a few of these were considered to be demonstrably of mesonephric origin. These tumors were usually associated with proliferating mesonephric remnants in the cervix. Similar tubuloglandular mesonephric proliferations without formation of a frankly malignant tumor have also been described in the cervix, most recently as florid mesonephric hyperplasia. This latter entity appears to be benign. Carcinoembryonic antigen (CEA) was focally positive in this cervical adenocarcinoma, suggesting that CEA may not be useful in distinguishing this variant from the more common mullerian adenocarcinoma of the cervix.

Carcinoembryonic Antigen↗
PubMed1986

Endocervical neoplasia in long-term users of oral contraceptives: clinical and pathologic observations.

Adenocarcinoma of the cervix has been associated with oral contraceptive use, often prolonged. The clinicopathologic features of seven cases of endocervical neoplasia in long-term combination pill users, all 33 years of age or younger, were reviewed and compared with seven cases in nonusers. Duration of drug use ranged from 4.5 to nine years. Adenocarcinoma in situ was found in all cases either in pure form or associated in invasive adeno- or adenosquamous carcinoma; squamous carcinoma in situ (CIS) was seen in two cases, one of which showed focal microinvasion. Hypersecretory changes were seen in adjacent endocervix in two cases but the morphology of neoplastic lesions was similar to that unassociated with pill use. The possible role of chronic hormonal stimulation in cervical carcinogenesis is discussed in light of these findings and current epidemiologic data.

Adenocarcinoma↗
PubMed1985

Sclerosing stromal tumor and bilateral teratomas: an unusual association.

Sclerosing stromal tumor is an uncommon ovarian neoplasm that has only recently been defined and distinguished from fibrothecoma. This case report describes a 17-year-old patient who presented with a large sclerosing stromal tumor and a smaller mature teratoma in the left ovary. Eighteen months later, an immature teratoma was discovered in the contralateral ovary and microscopic spread outside the ovary was documented at staging laparotomy. Mature and immature teratomas have been observed in opposite ovaries in a small number of patients. However, sclerosing stromal tumor, in over 60 published cases, has not been associated with other forms of ovarian neoplasia. Gonadal stromal differentiation, in fact, has not been convincingly demonstrated in teratomas. The observations in this case, therefore, appear to be unique.

Adolescent↗
PubMed1984

Leiomyomatosis peritonealis disseminata. A report of two cases and review of the literature.

Leiomyomatosis peritonealis disseminata (LPD) is an impressive clinical entity in women of reproductive age in which multiple nodules stud the pelvic and peritoneal surfaces, often mimicking disseminated carcinoma grossly. It has been associated with pregnancy and oral contraceptive drug use. In recent years, LPD has been reported with increasing frequency, often in women who are not pregnant. This report documents two additional cases of LPD; both cases concerned women who were not pregnant, and one case was associated with endometriosis.

Adult↗
PubMedDate not supplied

Tyrosine-rich crystalloids in pleomorphic adenoma: SEM findings and partial biochemical characterization.

The rare tyrosine-rich crystalloids (TRC) of salivary gland pleomorphic adenoma (PA) give a positive Million reaction indicating the presence of tyrosine. Their varied histochemical reactions, however, suggest a more complex composition. Two cases of TRC were encountered in a series of 144 PA (1.4%). Both were studied with several histochemical stains, and one tumor particularly rich in TRC was further examined with transmission and scanning electron microscopy and subjected to biochemical analysis using fresh-frozen tissue. TEM showed amorphous, electron-dense masses with no discernable internal structure. SEM revealed a geodelike structure of radially arranged, interlocking plates. Amino acid analysis of normal parotid, tumor with TRC, and a similar tumor without TRC indicated a slightly elevated level of tyrosine and arginine in the tumor with TRC. Polyacrylamide gel electrophoresis of tissue dissolved in sodium dodecyl sulfate revealed dense banding corresponding to polypeptides of a relative molecular weight of approximately 17,000 only in the TRC-rich sample. These bands on further analysis contained relatively large amounts of arginine. Tyrosine was present in only small amounts. TRC appear to be small proteins containing some tyrosine but rich in arginine.

Adenoma, Pleomorphic↗
PubMedDate not supplied

Cytodiagnosis and comparison of nondecidualized and decidualized endometriosis of the abdominal wall. A report of two cases.

We describe two cases of endometriosis of the abdominal wall occurring in young, multiparous women in which the diagnosis was made by fine needle aspiration biopsy. One case illustrates the cytologic features of non-decidualized endometriosis: a biphasic population of stromal and glandular cells. In contrast, the other case showed large, plump stromal cells in a distinctive myxoid background, creating a picture of decidualized endometriosis. The differential diagnoses of palpable masses in the abdominal wall and the importance of clinicopathologic correlation are discussed.

Abdominal Muscles↗
PubMedDate not supplied

Diagnosis of disseminated histoplasmosis by fine needle aspiration of the adrenal gland.

The cytologic findings in a case of disseminated histoplasmosis diagnosed by fine needle aspiration (FNA) of the adrenal gland are presented. Bilateral adrenal enlargement was discovered on CT scan in a patient whose systemic symptoms had been attributed to tuberculosis, but were resistant to antituberculous chemotherapy. The aspirate contained numerous histiocytes containing intracytoplasmic organisms with the morphologic features of Histoplasma capsulatum. The case shows that radiographically directed FNA of the adrenal gland, which has been recognized as a valuable aid in the confirmation of primary and secondary neoplasia, may also be quite useful in the less common setting of infectious disease involving this organ.

Adrenal Glands↗
PubMedDate not supplied

Melanuria.

The urinary cytologic findings in a patient with metastatic malignant melanoma, diffuse melanosis and melanuria are presented. The melanosis was diagnosed from the clinical appearance of a generalized slate-blue skin discoloration, which is probably caused by dermal deposition of excess melanin pigment. The melanuria was characterized microscopically by the presence of amorphous, dark-brown casts, which stained positively for melanin pigment, and numerous pigment-laden macrophages.

Back Pain↗
PubMedDate not supplied

Psammoma bodies in neuroendocrine carcinoma of the uterine cervix.

A case of neuroendocrine carcinoma of the uterine cervix with focal papillary clusters and psammoma bodies, features not previously seen in this tumor, is documented. Papanicolaou-stained cervicovaginal smears and pelvic washings are correlated with tissue sections of endocervical curettage, hysterectomy and cul-de-sac biopsy specimens. Although there was some variation in the cytologic features, the tumor cells were generally distinguished by nuclear molding, indistinct nucleoli, finely granular chromatin and scant cytoplasm. Argyrophil-positive intracytoplasmic granules were identified in tissue sections of the tumor. These granules were positive for ACTH and neuron-specific enolase using the immunoperoxidase technique. Ultrastructural studies were consistent with these findings. Neuroendocrine carcinoma of the cervix is therefore a cytologically distinctive tumor in which psammoma bodies may occur.

Carcinoma↗
PubMedDate not supplied

Pemphigus vulgaris with subclinical involvement of the uterine cervix. Report of a case with persistence of abnormal Papanicolaou smears posthysterectomy.

A case of pemphigus vulgaris is reported in which abnormal Papanicolaou smears continued prior to and after hysterectomy despite a normal pelvic examination. Microscopic foci of cervical pemphigus were found only in a retrospective study of the surgical material. Subclinical involvement of the cervicovaginal area with pemphigus, especially in a patient whose disease is apparently under control with steroids, can be a source of atypical Papanicolaou smears. The importance of careful colposcopic examination and clinical history is stressed for the gynecologist and cytopathologist, respectively.

Adult↗