Biomedical subjects

P T Simonian

Publications and source records attributed to P T Simonian.

At least 55 records · Page 3Linked to original sources

PubMed1995

Titanium contamination of recycled Cell Saver blood in revision hip arthroplasty.

The use of Cell Saver blood during revision hip arthroplasty has many benefits, both medical and economic. After a review of the current literature, to our knowledge, no case of metallic debris has been reported in the blood after complete treatment with the Haemonetics Cell Saver (Braintree, MA) and appropriate filter system. A case of total hip revision of a loose, cemented acetabular component with a commercially pure titanium metal backing and a titanium alloy plasma-spray textured surface was undertaken. The titanium alloy femoral component was not visibly loose and was not revised. The joint lining tissues were black. Throughout the procedure, the operative site was suctioned with a double-lumen heparinized catheter that delivered blood and other materials to a Haemonetics Cell Saver 3 Plus. The reservoir and filter unit used were the compatible Bentley BCR-3500 (Baxter, Irvine, CA), a system capable of filtering particulates down to 20 microns. Prior to infusion of the salvaged blood, many large black clumps of material were observed mixed in the blood. Some measured 10 x 5 x 5 mm and could easily be seen macroscopically. Light microscopy demonstrated red blood cells with intermixed neutrophils, and black foreign material scattered as separate particles and within the cytoplasm of the scattered histiocytes. Energy dispersive analysis of the black material confirmed the composition as primarily titanium with minute quantities of copper, iron, phosphorous, and sulfur. A scanning electron photomicrograph of one of the specimens demonstrated a large conglomerate, approximately 2,000 microns in diameter, composed primarily of titanium and organic material.(ABSTRACT TRUNCATED AT 250 WORDS)

Aged↗

PubMed1995

Thermal expansion modular femoral head extractor for revision total hip arthroplasty.

Removal of a prosthetic modular femoral head is sometimes desirable during revision hip arthroplasty. A femoral head extractor was designed to heat and expand the prosthetic femoral head, apply a gentle distraction load, and remove the femoral head without injury to the femoral neck, taper, or bone-prosthesis interface. The device was used clinically in six hip revision cases. In five hips with cobalt-chrome heads and titanium alloy tapers, femoral heads were removed successfully; femoral fixation was maintained and femoral components were not visibly damaged. In the sixth case, the female portion of the taper junction was contained in a long femoral head sleeve. Heating the ball did not adequately expand the sleeve to allow easy ball removal.

Femur Head↗

PubMed1995

The retrograde medullary superior pubic ramus screw for the treatment of anterior pelvic ring disruptions: a new technique.

Retrograde medullary screws were used in 26 patients with unstable pelvic ring injuries to stabilize the superior public ramus fractures. The posterior pelvic ring fractures and dislocations were fixed with iliosacral screws. The retrograde screws were inserted after closed manipulative reductions of the superior pubic ramus fractures in 15 patients and after open reduction in nine patients. We were unable to insert the screw in two patients due to anatomical variations. One screw was misplaced superior to the pubic ramus and noted only on the postoperative computed tomography scan. Another patient experienced symptomatic screw disengagement that required reoperation. All fractures healed and no infections developed. Blood loss was minimal for the percutaneous procedures. The technique provides stability to the anterior pelvic ring without the need for extensile surgical exposures. The complications of both anterior pelvic external fixation and plating are avoided, yet this technique has its own potential problems. The procedure is described in detail, and the early results and complications are documented in our first 26 patients.

Acetabulum↗

PubMed1995

Early results of percutaneous iliosacral screws placed with the patient in the supine position.

The operative management of pelvic ring fractures and dislocations is difficult. Posterior pelvic ring disruptions are often associated with severe soft-tissue injuries and high infection rates. Percutaneous iliosacral screw fixation of the posterior pelvis has become popular with improved fluoroscopic imaging techniques. The percutaneous iliosacral screw technique after closed reduction of the posterior pelvic disruption minimally violates the soft-tissue envelope and should diminish both the operative blood loss and infection rate. The early results and complications are documented in our first 68 patients.

Adolescent↗

PubMed1995

Clinical efficacy of electroneurometer screening in carpal tunnel syndrome.

The authors evaluated the motor latency values of 72 median nerves assessed with the compact, hand-held, battery-powered NervePace Electroneurometer. Results of this test were compared to those of clinical examination, standard electrodiagnostic tests, and median nerve findings of compression at the time of surgery in 23 patients. The motor latency values obtained with an electroneurometer correlated positively with those from routine electromyography (EMG): sensitivity and specificity were calculated for the ability to diagnose carpal tunnel syndrome (CTS) (> 3.9 ms considered abnormal). This study identified a sensitivity of 85.7% and a specificity of 87.5% in predicting CTS, as confirmed by complete EMG and electroconduction studies.

Carpal Tunnel Syndrome↗

PubMed1995

Incidence of hepatitis C in patients requiring orthopaedic surgery.

We tested prospectively for hepatitis C virus (HCV) in one orthopaedic surgeon's operative practice for one year. Of 425 consecutive patients, 19 (4.5%) were positive for HCV infection using a second-generation screening assay. The highest correlation with a positive test was the presence of tattoos and the second highest was intravenous drug abuse, but only after a second interview, since most patients did not report this risk on the initial questionnaire. Based on the criteria of the US Public Health Services algorithm, nine (47%) of the patients with a positive initial screening test or 2.2% of the 425 patients, had hepatitis C (both anti-HCV-positive and elevated alanine aminotransferase). In this group of nine, the presence of tattoos had the highest and intravenous drug abuse the second highest correlation, also after the second interview. There is no vaccine available for the prevention of HCV infection, and prophylactic immunoglobulin therapy has no proven value for primary exposure.

Adult↗

PubMed1995

Indirect forces and patella fracture after anterior cruciate ligament reconstruction with the patellar ligament. Case report.

Patella fracture is either an infrequent or underreported complication after anterior cruciate ligament (ACL) reconstruction using a portion of the patellar ligament. Patella fracture pattern has been related to the mechanism of injury. Direct fractures resulting from impaction forces delivered to the patella are typically stellate or comminuted. Indirect fractures resulting from tensile stresses applied across the extensor mechanism typically are displaced transverse disruptions. After ACL reconstruction using a portion of the patellar ligament, Y-shaped stellate fractures can occur. Fracture pattern seems related to the time elapsed since the harvest; stellate fractures occur following stumbles or slips without direct injury early in the postoperative period while transverse fractures occur late. This article describes two cases of patella stellate fractures that occurred in patients who underwent ACL reconstruction using patellar graft.

Adult↗

PubMed1995

The acetabular T-type fracture. A biomechanical evaluation of internal fixation.

The purpose of this study was to evaluate the stability of different types of internal fixation requiring anterior, posterior, or combined surgical approaches for the T-type acetabular fracture. Eight specimens were loaded 25 times in a cyclic manner to 150 N for each type of fixation construct evaluated. The model attempted to range the hip through an arc of motion anticipated in the limited activities expected after surgery. Strain gauges were placed on the 3 fracture planes of the T-type fracture. These gauges measured displacements. Internal fixation consisted of a single anterior column plate, compared with a single posterior column plate, compared with simultaneous placement of both anterior column and posterior column plates. The differences in displacements measured between the 3 types of fixation at each of the 3 fracture sites were not statistically significant. In evaluating motion at the anterior fracture line, the anterior plate made the largest contribution to stability, although this result was not statistically significant. The posterior plate similarly contributed most to posterior fracture stability, although again not statistically significant. Each of the 3 fixations controlled the inferior fracture line motions in a comparable manner.

Acetabulum↗

PubMed1995

Anterior versus posterior provisional fixation in the unstable pelvis. A biomechanical comparison.

Pelvic ring injuries with associated hemorrhage often require provisional fixation to achieve tamponade. Biomechanics information regarding these provisional fixators is unknown. Six fresh-frozen cadaveric pelvic specimens were physiologically loaded, first intact and then after each of the following modifications: disrupted--unilateral superior and inferior rami osteotomies, ipsilateral anterior and posterior sacroiliac joint, and sacrospinous and sacrotuberous ligament disruption; disrupted and with placement of a Ganz pelvic resuscitation clamp; and disrupted and with placement of a simple anterior 2-bar external fixator. This injury resulted in significant motion at the disrupted rami and the injured sacroiliac joint, compared with the intact pelvic specimen. Motions at the superior ramus and injured sacroiliac joints were significantly (p < 0.05) greater than the intact specimen, with both the external fixator and the Ganz clamp. Motions at the superior ramus and injured sacroiliac joints were not significantly (p < 0.05) different when comparing the Ganz clamp to the external fixator. However, the anterior external fixator decreased motion to a greater degree at the disrupted rami, whereas the Ganz clamp decreased motion to a greater degree at the disrupted sacroiliac joint.

Aged↗

PubMed1995

A rational approach to pelvic trauma. Resuscitation and early definitive stabilization.

The patient with polytrauma and an unstable pelvic ring injury is a treatment challenge. The orthopaedic surgeon should be involved in the care when the patient is brought into the hospital. Rapid pelvic ring stability should diminish pelvic hemorrhage. Early treatment decisions have significant impact on subsequent options. A team approach using open communication among the various subspecialties allows coordinated care and optimizes outcome. Early, definitive pelvic internal fixation is difficult yet beneficial.

Adolescent↗

PubMed1995

Carcinogenicity and metallic implants.

The literature related to the carcinogenetic potential of metallic implants was reviewed. There were 20 cases described in which tumors were identified in proximity to metallic implants. These cases occurred over a 34-year period. Investigators have identified a 70% increased incidence of lymphomas and hematopoietic tumors over that in the general population in patients who had received total hip arthroplasties. Carcinogenicity theories include the potential direct toxicity of materials, the effects of surface properties, the electromotive potential created by dissimilar metals in contact, the immunologic response to implants, and finally, the sustained presence of low-grade infection. Corrosion is a well-documented phenomenon and occurs with any type of metal. The rate of formation of corrosion products and their toxicity varies with the implant composition. Toxic effects of metals, such as malignant potential and other adverse effects, have been demonstrated in animal models. The published information on this controversial and very poignant issue of metallic carcinogenesis is useful for all orthopedic surgeons.

Animals↗

PubMed1995

Fracture of the cuboid in children. A source of leg symptoms.

We report eight cases of fracture of the cuboid in seven children under four years of age, collected during a two-year period. There was no history of trauma in five of the patients. This fracture is rarely diagnosed and has probably been under-reported. Small children are poor historians and difficult to examine, and early radiographs may be normal or have only subtle abnormalities. Cuboid fracture should be considered in the differential diagnosis of limping toddlers, and a bone scan may be needed to confirm the diagnosis earlier than radiography. These fractures heal completely, without sequelae. Treatment in a short-leg walking cast is recommended, primarily for reasons of comfort.

Casts, Surgical↗

PubMed1994

Extramedullary skeletal traction for intramedullary femoral nailing.

The through-and-through forms of femoral skeletal traction that are often used during intramedullary nailing for femur fractures can present two problems: (a) impingement with the intramedullary nail, requiring repositioning of the traction pin intraoperatively under radiographic control, to a position that may not optimally control the fracture; and (b) the risk of contaminating the intramedullary canal that will soon contain the metallic fixation device, especially when placed in the emergency room or at the bedside. Two new forms of extramedullary skeletal femoral traction are presented. The pullout strength and optimal positioning of these devices on the distal femur were evaluated. The first form of extramedullary traction evaluated was the large AO/ASIF pinless clamp. The second form of extramedullary traction, the extramedullary skeletal clamp, was based on a modification of the Gardner-Wells tong. These two forms of skeletal traction were compared with standard tensioned Kirschner wire (K-wire) through-and-through traction. Six fresh-frozen distal femora from donors (average age 29 years) were used to test the three femoral traction devices. Five of these specimens were skeletally mature. A total of 38 pullout tests were conducted. The pullout strength of the tested devices was in the following descending order: (a) tensioned K-wire; (b) extramedullary skeletal clamp (in the optimal metadiaphyseal position, 77% the strength of the K-wire); and (c) large ASIF pinless clamp (in the optimal metaphyseal position, 46% the strength of the K-wire). The mode of failure for each device was cut out through or from the bone.(ABSTRACT TRUNCATED AT 250 WORDS)

Adolescent↗

PubMed1994

Internal fixation of the unstable anterior pelvic ring: a biomechanical comparison of standard plating techniques and the retrograde medullary superior pubic ramus screw.

The purpose of this study was to evaluate pubic ramus fracture fixation. This biomechanical evaluation compared standard plating techniques with retrograde medullary screw fixation of a superior pubic ramus fracture in a pelvic fracture model. Six fresh-frozen, cadaveric pelvic specimens with a mean age of 79 years were harvested. These specimens were physiologically loaded according to the following modifications and instrumentations: (a) intact; (b) an APC-II unstable pelvic injury, specifically, unilateral superior and inferior rami osteotomies combined with ipsilateral anterior sacroiliac (SI) joint, sacrospinous, and sacrotuberous ligamentous disruptions, without fixation; (c) disrupted as in (b) but fixed anteriorly with a 10-hole 3.5-mm reconstruction plate contoured to the superior ramus and secured with four 3.5-mm cortical screws; (d) disrupted as in (b) but fixed anteriorly with a 10-hole 3.5-mm reconstruction plate contoured to the superior ramus and secured with six 3.5-mm cortical screws; (e) disrupted as in (b) but fixed anteriorly with a 4.5-mm retrograde medullary superior pubic ramus cortical screw 80 mm long (medial to the hip joint); and (f) disrupted as in (b) but fixed anteriorly with a 4.5-mm retrograde medullary superior pubic ramus cortical screw 130 mm long that was extraarticular and engaged the lateral iliac cortex cephalad to the ipsilateral hip joint. The posterior disruptions of the pelvic ring were not fixed. The APC-II injury created in this study resulted in significant (p < 0.05) motion at the disrupted rami and the injured SI joint, compared with the intact pelvic specimen.(ABSTRACT TRUNCATED AT 250 WORDS)

Aged↗

PubMed1994

Box plate fixation of the symphysis pubis: biomechanical evaluation of a new technique.

The purpose of this study was to compare common techniques of pubic symphyseal fixation with a new method, the "box plate," for fractures of the pelvis where the bone is osteopenic. This symphyseal fixation construct consists of two, two-hole, 4.5-mm narrow dynamic compression plates (DCP) oriented parallel to one another. One plate is recessed within the symphysis, and the other is located on the pubic tubercles. The plates are interlocked using two 6.5-mm fully threaded screws, forming a box-like construct. To determine the mechanical properties of this construct, five fresh, cadaveric pelvic specimens with a mean age of 75 years were harvested. The femora of each specimen were potted into containers and fixed to the base of a materials testing machine. The pelvis was constrained from rotating about the hip joints by anterior and posterior restraints. A vertical compressive load was applied through the lumbar spine. Force to a magnitude of 1,000 N was applied through three cycles. Gapping motions at the symphysis pubis (SP) and the sacroiliac (SI) joints, and flexion-extension of the sacrum with respect to the ilia were measured under the following conditions: (a) intact, (b) SP ligament, unilateral anterior SI ligaments, and ipsilateral sacrospinous and sacrotuberous ligaments disrupted (anteroposterior compression type II injury), and these injuries fixed using (c) a 4.5-mm narrow two-hole DC plate placed on the superior SP held by two cancellous bone screws, (d) the DC plate well as a single 7.0-mm cannulated cancellouoffliosacral lag screw across the injured SI joint, (e) the DC plate and a five-hole 3.5-mm reconstruction plate on the anterior SP, (f) a 3.5-mm, four-hole, DC plate on the superior SP using four fully threaded screws, and (g) the box plate symphyseal construct described above. All fixations reduced SP joint gapping compared to the disrupted joint. However, all but the box plate still allowed significantly greater motion than the intact SP joint. No fixation significantly reduced SI joint gapping or sacral flexion compared to the injured state.

Aged↗

PubMed1994

Biomechanical simulation of the anteroposterior compression injury of the pelvis. An understanding of instability and fixation.

Seven fresh cadaveric pelvic specimens were biomechanically analyzed. Testing was first performed on intact pelves and then after progressive disruption of the (1) symphysis pubis, (2) unilateral anterior and interosseous sacroiliac ligaments and capsule, (3) ipsilateral sacrospinous and sacrotuberous ligaments; and fixation with a 4.5-mm narrow dynamic compression plate at the symphysis pubis, or a 4.5-mm narrow dynamic compression plate at the anterior sacroiliac joint with and without the symphysis pubis plate, or a 7.0-mm sacroiliac lag screw anchored into the S1 vertebral body with and without the symphysis pubis plate. Symphyseal gapping occurred after isolated symphysis pubis disruption. With additional disruption of the unilateral sacroiliac joint ligaments, symphysis pubis displacement was unaffected; however, the injured sacroiliac joint gap displacement, and sacroiliac joint flexion angulation on both intact and injured sides increased as compared to the specimen in the intact state. Further disruption of the ipsilateral sacrotuberous and sacrospinous ligament complex produced little additional motion at either symphysis pubis or sacroiliac joints. Plate fixation of the symphysis pubis alone reduced symphysis pubis motion, but not sacroiliac motion. Use of sacroiliac fixation alone without a symphysis pubis plate did not affect symphysis pubis motion. The symphysis pubis plate is the key to stabilizing symphysis pubis motion, and similarly, sacroiliac joint fixation is required to control sacroiliac joint motion. Both single iliosacral screws and plates produced equivalent decreases in sacroiliac joint motion.

Biomechanical Phenomena↗

PubMed1994

Iatrogenic fractures of the femoral neck during closed nailing of the femoral shaft.

We have reviewed our experience of four iatrogenic femoral neck fractures in 315 consecutive closed intramedullary nailings with the AO/ASIF universal femoral nail. The average neck-shaft angle in the bones that fractured was 139.3 degrees +/- 1.2 degrees SD (136 to 141); in the whole series the average neck-shaft angle was 125.3 degrees +/- 8.6 degrees and only 11 had angles of more than 135 degrees. The upper ends of the nails in the four which fractured were 17 mm, 5 mm, 3 mm, and 1 mm below the tip of the greater trochanter. In the seven patients with neck-shaft angles greater than 135 degrees but with no fracture, none of the nails had been inserted beyond the tip of the greater trochanter. We nailed six cadaver femora to simulate the forces produced by intramedullary nailing. Despite deep insertion, only one of the six sustained a neck fracture. This specimen had a radiographic neck-shaft angle of 140 degrees against an average of 127.3 degrees +/- 4.0 degrees for the other five. We believe that the medial prong of the AO insertion jig, with its medial overhang of 2 to 3 mm, may impinge on the superior aspect of a valgus femoral neck during final impaction, causing a neck fracture. This may be avoided by leaving the end of the nail above the tip of the trochanter in such cases.

Adolescent↗

PubMed1994

Effect of sterilization and storage treatments on screw pullout strength in human allograft bone.

Many conflicting studies have been performed evaluating the effects of sterilization and storage treatments on the mechanical properties of allograft bone. In the current study, four right and left matched, sterile, deep-frozen, tibial pairs from human donors with an average age of 32 years were tested. One tibia from each pair served as a matched control for the opposite side. Each tibia was cut into four equal segments. One segment of each tibia underwent no treatment; the other three underwent one of the following treatments: irradiation, freeze drying, or ethylene oxide (ETO). Screw pullout tests were performed using four 3.5-mm cortical screws per segment. Sixteen screw pullout tests were performed for each allograft treatment. The freeze-dried specimens required significantly less force for screw pullout. The screw pullout force for the irradiated specimens and the ETO specimens did not significantly differ from their controls. These results indicate that freeze drying affected screw pullout strength. This method of processing should be questioned for structural allografts in which screw fixation is mandatory. The use of irradiation or ETO for sterilization may not have an adverse effect on screw pullout strength.

Biomechanical Phenomena↗