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Biomedical subjects

P Svec

Publications and source records attributed to P Svec.

At least 109 records · Page 6Linked to original sources
PubMed1975

The influence of N-(2-hydroxyethyl)-palmitamide on virus-induced sarcomas in chickens and Rauscher leukemia in mice.

The effect of N-(2-hydroxyethyl)-palmitamide (PEA), an active endogenous compound, which may be useful in preventing virus infections of the respiratory tract, was studied in chicken sarcoma RBA-34 and mouse Rauscher leukemia. The experiments showed that PEA did not influence the induction, development and severity of experimental oncogenic diseases investigated.

Animals↗
PubMed1975

The effect of long-term administration of N-(2-hydroxyethyl)palmitamide on the chemotherapy of RBA rat leukemia.

The effects of N-(2-hydroxyethyl) palmitamide (PEA) a natural and antitoxic substance on the treatment of RBA rat leukemia were studied. Repeated administration of PEA prolonged substantially survival of leukemic animals in the course of the treatment with cis-diamminedichlor-platinum (cis-Pt(II) in combination with cyclophosphamide, vincristine and methotrexate respectively. The most advantageous combination used was the cis-Pt(II) with methotrexate and PEA administration even improved the treatment results. The long-termed PEA treatment depressed first of all undesirable side effects and enabled to use higher therapeutic dosage of chemotherapeutics and improved the final results.

Animals↗
PubMed1972

The effect of phospholipids on anaphylactic histamine release.

1. Histamine release by antigen from three sensitized rat tissues is potentiated by phosphatidyl serine (PS). The effect is greatest with isolated peritoneal cells. Phosphatidyl inositol, ethanolamine, choline and phosphatidic acid are inactive.2. PS greatly increases the rate of antigen-induced histamine release and only slightly prolongs the duration of the release process.3. PS shows a concentration-dependent effect over the range 1-10 mug/ml. At 10 mug/ml it is active over a wide range of antigen concentrations.4. Calcium ions are necessary for the potentiation by PS of antigen-induced histamine release from rat peritoneal cells.

Animals↗