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Biomedical subjects

P Stolba

Publications and source records attributed to P Stolba.

70 records · Page 4Linked to original sources
PubMed1987

Comparison of N-acetyl-beta-glucosaminidase and albuminuria with clinical finding of microangiopathy in type I diabetes mellitus.

N-acetyl-beta-Glucosaminidase activity in serum and urine and microalbuminuria were measured in 70 type-I diabetics and compared with glycated serum protein as well as with the finding of diabetic retinopathy. A significantly increased N-acetyl-beta-glucosaminidase activity in serum correlated positively with glycated protein but not with the development of retinopathy. Urinary N-acetyl-beta-glucosaminidase activity and albuminuria were significantly increased in diabetics with (p less than 0.001) or without (p less than 0.01) retinopathy as compared to healthy controls. A significant positive correlation was observed between urinary N-acetyl-beta-glucosaminidase activity and albuminuria (r = 0.73, p less than 0.01) as well as between blood pressure and albuminuria (r = 0.51, p less than 0.05).

Acetylglucosaminidase↗
PubMed1987

New ways in treatment on insulin-dependent diabetes.

In our work we have tried to show that the only appropriate method of treatment for a type I diabetic is that which helps to maintain a near-normal compensation, which does not bother the patient and allows him a flexible way of life, and for which there is a sufficient technical equipment including the possibility of blood glucose monitoring. We have found out that all modes of insulin administration are effective, all can achieve a good compensation. Where the both conventional methods (basal-bolus regimen, multiple doses regimen) fail, we use the continuous subcutaneous insulin infusion (CSII). But we warn of undue optimism, and we recommend to use the CSII treatment only during hospitalization, when an exact blood glucose monitoring can be secured. An out-patient CSII treatment is--according to our experience--possible only when a consiliary supervision or a phone consultation of the patient with the attending team can be provided round the clock. We recommend therefore to use CSII routinely as a method of treatment only when the following preconditions are fulfilled an exact indication, education and motivation, technical equipment, and therapeutic supervision in outpatient treatment.

Adolescent↗
PubMed1986

Vasoactive role of endogenous digoxin-like factor in rats with experimental hypertension.

Acute blockade of circulating digoxin-like factor endoxin lowered blood pressure (BP) by a decrease in systemic resistance which was partially compensated by an increased cardiac output. The important participation of circulating endoxin in the maintenance of elevated BP was proved in young animals with DOCA-salt and one-kidney, one-clip (1K1C) Goldblatt hypertension but not in young spontaneously hypertensive rats (SHR). In rats with DOCA-salt as well as with 1K1C hypertension, the role of endoxin differed according to the age at which the hypertensive stimulus was applied. The significant role of the "digoxin-like" factor in BP regulation was found only in young animals. On the other hand, in SHR the participation of endoxin in the maintenance of elevated BP rises with the age. High salt intake prior to sexual maturation seems to be critical for later participation of the "digoxin-like" factor in long-term BP regulation.

Age Factors↗
PubMed1985

The importance of endogenous digoxin-like factors in rats with various forms of experimental hypertension.

The acute administration of anti-digoxin serum (ADS) caused a pronounced long-lasting blood pressure decrease in young DOCA-salt hypertensive rats. The decrease of blood pressure was only moderate in 1K-1C Goldblatt rats while there was no change of blood pressure after the ADS injection in spontaneously hypertensive rats. However, the blockade of endogenous digoxin-like factors lowered blood pressure only in those hypertensive rats which were treated with DOCA-saline from youth but not in animals treated in the same manner only in adulthood. The age period at which salt intake was increased, could be responsible for the susceptibility of animals to salt- and volume-dependent forms of experimental hypertension as well as for the participation of slow acting humoral pressor agents in the induction and/or maintenance of elevated blood pressure. It is evident that endogenous digoxin-like factor(s) participate in a greater response of young rats to the hypertensive stimuli.

Angiotensin II↗
PubMed1985

Endogenous digoxin-like factor contributes to the elevation of systemic resistance in rats exposed to high salt intake from prepuberty.

The acute administration of anti-digoxin serum (ADS) caused a pronounced blood pressure decrease only in those hypertensive rats that were treated with desoxycorticosterone acetate (DOCA) and 1% saline from prepuberty. This was due to a rapid decrease in systemic resistance which was partially compensated by increased cardiac output. There were no similar effects of ADS in rats treated in the same manner in adulthood only. Different mechanisms might be responsible for blood pressure elevation induced by high salt intake in youth or in adulthood. The participation of endogenous digoxin-like factor in the maintenance of elevated systemic resistance in DOCA-salt hypertensive rats is a typical case.

Animals↗
PubMed1984

A different role of digoxin-like factor in the maintenance of elevated blood pressure in rats treated with DOCA and saline in youth or only in adulthood.

The acute administration of anti-digoxin serum (ADS) caused a pronounced long-lasting blood pressure decrease only in those hypertensive rats that were treated with DOCA and 1% saline from prepuberty. There was no effect of ADS on blood pressure of rats treated in the same manner in adulthood only. The age at which salt intake was increased could be responsible for both the susceptibility of animals to salt-dependent forms of experimental hypertension and the participation of slow-acting humoral pressor agents (endogenous digoxin-like factors) in the maintenance of their elevated blood pressure.

Aging↗
PubMedDate not supplied

[The value of the carbohydrate metabolism response for assessment of early prognosis in patients with acute myocardial infarct without previously detected diabetes].

The authors examined 68 patients with a acute myocardial infarction without previously detected diabetes. They evaluated the importance of the relationship of the intensity of the stressor, humoral stress response and the response of the carbohydrate metabolism for the early prognosis of the infarction. Despite the complexity of these relations and heterogenity in the group of these patients, the authors confirmed the prognostic importance of hyperglycaemia, cortisolaemia and urinary catecholamine levels, and based on their own experience, they recommended to follow up these indicators during the first days after development of the infarction.

Adult↗
PubMedDate not supplied

[The carbohydrate metabolism and stress hormone response during acute myocardial infarct in persons without diagnosed diabetes].

The authors examined 68 patients with a acute myocardial infarction without previously detected diabetes. They evaluated some indicators of the humoral stress response and the response of the carbohydrate metabolism during a recent infarction. They found very complicated interrelations between hormones of the stress reaction and indicators of the carbohydrate metabolism under conditions of circulatory stress. Despite this they detected some dominating trend and compared their findings with data from the literature.

Adult↗
PubMedDate not supplied

[The carbohydrate metabolism and stress hormone response in acute myocardial infarct--its importance in predicting permanent disorders of glucoregulation].

The authors examined in a group of 68 patients with a acute myocardial infarction (without confirmed diabetes) some indicators of the humoral stress reaction and the response of indicators of the carbohydrate metabolism during circulatory stress. After three years they re-examined 48 of these patients with special attention to their carbohydrate metabolism. Based on the assembled results, the authors sought a relationship between findings during the acute circulatory stress and the level of the carbohydrate metabolism after three years. In future diabetics they found during the period of the acute infarction higher levels of immunoreactive insulin, a reduced IRI/blood sugar ratio and a higher excretion of urinary catecholamines. In the OGTT performed one week after the infarction they found a higher sum of C-peptide, a shift of the peak of IRI secretion and reduced IRI/blood sugar ratio. These finding could indicate the development of a permanently impaired glycoregulation and lang-term prognosis of these patients.

Adult↗