[Internists--Update 2006].
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Biomedical subjects
Publications and source records attributed to P Stiefelhagen.
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Patients with thoracic pain, acute dyspnea and palpitations represent an acute emergency for the general physician. In every case, initial information is provided by an ECG obtained immediately. Ifa suspected acute coronary syndrome is confirmed, continuous ECG rhythm monitoring must be performed. In addition, oxygen must be administered, the patient placed in an appropriate position, and analgesics and antiplatelet medication given. In the event of pulmonary edema, too, initial measures must include oxygen administration, appropriate positioning, administration of a rapid-acting loop diuretic and, where indicated, nitroglycerin. Should tachycardic arrhythmia occur, the width of the ventricular complex must be measured in the ECG before deciding on further treatment. In the out-of-hospital setting, no more than one antiarrhythmic should be given.
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In the majority of cases, the exercise ECG serves to confirm or exclude the presence of myocardial ischaemia. It is applied both as a primary diagnostic tool in CAD patients with dyspnea or chest pain, and also to monitor the success of treatment. It is, however, important to remember that the information provided by an exercise ECG will vary depending on the patient's age and individual circumstances, and this may make additional investigations necessary.
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Antithrombotic medication can be performed by means of heparins (non-fractionated heparin, low molecular heparins) or the pentasaccharide Fondaparinux as well as with oral vitamin K antagonists. The use of a low molecular heparin is initially recommended for the sake of practicability and safety in case of patients suffering from deep venous thrombosis of the leg and pelvis with subsequent long-term oral medication using a vitamin K antagonist (Marcumar) for anticoagulation. The most frequent indications for long-term anticoagulation are deep leg and pelvis thromboses, pulmonary embolism with atrial fibrillation, artificial prosthetic valves and open oval foramen with ischaemic cerebral infarction. In case of patients with chronic atrial fibrillation it is expedient to initiate permanent anticoagulation according to a risk score. For the purpose of controlling oral anticoagulation it is recommended to employ the INR value in place of Quick's value because these data are better comparable. In case of atherothrombotic diseases secondary prevention will always indicate administration of a thrombocyte aggregation inhibitor. In such cases acetylsalicylic acid is recommended as the standard preparation.
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Taking care of the dying is an important and demanding concern for the general physician. In addition to the amelioration of pain, he also has to help the patient to cope with dyspnea, vomiting, constipation, depression and anxiety. To this end, not only morphine but also anti-emetic drugs, laxatives and peristalsis-stimulating suppositories, benzodiazepines and neuroleptics with a sedating effect can make it easier for the patient during the terminal phase of his life. As least as important as the support provided by medication, however, are sympathetic communication with the patient and human warmth.
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