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Biomedical subjects

P Steadman

Publications and source records attributed to P Steadman.

12 recordsLinked to original sources

Exchange bias in spin-engineered double superlattices.

Exchange bias has been observed in sputtered magnetic double superlattices which consist of a ferromagnetically coupled superlattice grown on an antiferromagnetically (AF) coupled superlattice. This system exhibits a parallel domain wall, a spin flop transition, and exchange bias when the anisotropy is large in the AF block. This work shows that neither the domain wall nor the spin flop are directly related to exchange bias but that the anisotropy is essential.

Journal Article↗

Adsorption of carbon monoxide on Ni(110) above atmospheric pressure investigated with surface X-ray diffraction.

The crystallographic structure of CO adsorbed on Ni(110) has been investigated with x-ray diffraction at ambient pressures of CO ranging from 2.3 to 10(-10) bars. At room temperature, the high pressure and vacuum structures are identical. Above room temperature ( approximately 130 degrees C), the high pressure of CO induces a restructuring of the Ni substrate that develops strained (111) microfacets.

Journal Article↗

Stability of polar oxide surfaces.

The structures of the polar surfaces of ZnO are studied using ab initio calculations and surface x-ray diffraction. The experimental and theoretical relaxations are in good agreement. The polar surfaces are shown to be very stable; the cleavage energy for the (0001)-Zn and (0001;)-O surfaces is 4.0 J/m(2) comparable to 2.32 J/m(2) for the most stable nonpolar (1010) surface. The surfaces are stabilized by an electronic mechanism involving the transfer of 0.17 electrons between them. This leads to 2D metallic surface states, which has implications for the use of the material in gas sensing and catalytic applications.

Journal Article↗

An ultrahigh-vacuum chamber for surface X-ray diffraction.

An ultrahigh-vacuum environmental chamber for surface X-ray diffraction on Station 9.4 at the Synchrotron Radiation Source, Daresbury Laboratory, is described. Film growth can be monitored by simultaneously recording the Auger signal and the X-ray intensity at a particular point in reciprocal space. Such in situ measurements are essential for understanding the dynamic processes that occur during adsorption. An example is given in which the specularly reflected X-ray signal is correlated with Auger plots, during growth of Tl on Cu(001). In addition, the diffractometer and chamber combination allow large reconstructions to be investigated as shown by the in-plane structural analysis of the c(4x4) InSb surface. A study of the layer structure of Cr on Ag(001), in which an extended out-of-plane detector assembly was used, is also presented.

Journal Article↗

The Genome Sequence DataBase (GSDB): improving data quality and data access.

In 1997 the primary focus of the Genome Sequence DataBase (GSDB; www. ncgr.org/gsdb ) located at the National Center for Genome Resources was to improve data quality and accessibility. Efforts to increase the quality of data within the database included two major projects; one to identify and remove all vector contamination from sequences in the database and one to create premier sequence sets (including both alignments and discontiguous sequences). Data accessibility was improved during the course of the last year in several ways. First, a graphical database sequence viewer was made available to researchers. Second, an update process was implemented for the web-based query tool, Maestro. Third, a web-based tool, Excerpt, was developed to retrieve selected regions of any sequence in the database. And lastly, a GSDB flatfile that contains annotation unique to GSDB (e.g., sequence analysis and alignment data) was developed. Additionally, the GSDB web site provides a tool for the detection of matrix attachment regions (MARs), which can be used to identify regions of high coding potential. The ultimate goal of this work is to make GSDB a more useful resource for genomic comparison studies and gene level studies by improving data quality and by providing data access capabilities that are consistent with the needs of both types of studies.

Base Sequence↗

Plasma magnesium levels in a population of psychiatric patients: correlations with symptoms.

Plasma magnesium levels were tested in a group of 155 psychiatric in-patients with a variety of diagnoses and were correlated with the severity of their symptoms. We hypothesized that lower Mg levels would correlate with a higher degree of anxiety, tiredness and other symptoms characteristic of Mg deficiency. No such correlations were observed. However, Mg levels varied widely, with 22.4% below, and 10.4% above the normal range. There was a strong association for more disturbed and excitable patients to have abnormal (either high or low) levels. We speculate that more disturbed patients might have some abnormality of Mg metabolism with possible therapeutic implications.

Adolescent↗

Abnormal locomotion in the rat after administration of a TRH analogue.

Previous studies have indicated that the TRH analogue CG3703 induces changes in gross measures of motor activity. The purpose of the present study was to determine whether it affected the underlying components of the locomotor cycle, stance and swing times. It has been found that while total stride time was unaffected there was an alteration in the balance between swing and dual stance times such that treated rats used longer swing times and shorter dual stance times. For both control and treated animals dual stance time increased with stride time. However, for any particular stride time, treated animals deployed longer swing times and shorter dual stance times. Possible mechanisms for these observations are discussed.

Animals↗