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Biomedical subjects

P Spiller

Publications and source records attributed to P Spiller.

At least 73 records · Page 4Linked to original sources
PubMed1977

[Systolic and diastolic left ventricular function in hypertrophic obstructive cardiomyopathy].

Systolic and diastolic left ventricular and myocardial performance were analysed in ten patients with hypertrophic obstructive cardiomyopathy (HOCM) from biplane cineangiograms and simultaneous pressure recordings. In spite of significant geometrical abnormalities, pump function of the left ventricle on the average was normal. Only in two cases ejection fraction and isovolumic phase indices, respectively, were moderately reduced. On the contrary nine of ten patients had a considerable reduction of left ventricular distensibility, partly due to a decreased myocardial compliance. The symptoms of patients with HOCM cannot be explained by an impaired systolic pump function, they are primarily caused by a disturbed ventricular und myocardial function during diastole.

Adult↗
PubMed1976

[The effect of contrast medium injection into the left ventricle on systolic and diastolic ventricle function].

The influence of contrast medium on systolic and diastolic left ventricular function was studied in eight patients with coronary heart disease and in five dogs during and five minutes after ventriculography. Two biplane ventriculograms were performed in 5-minute intervals, in the dogs an additional one after 10 minutes. 0.66 cc/kg BW of sodium methyl-glucamin-iothalamate were injected during diastole into the left ventricel. 1. During ventriculography there are only slight changes of left ventricular volumes, pressures and diastolic compliance. The first four opacified heart cycles can be evaluated for the analysis of left ventricular function. 2. In patients with coronary heart disease there are much more pronounced alterations of systolic ventricular function 5 minutes after Ventriculography than in the normal dog. The ischemic ventricle has a reduced tolerance for volume load and negative inotropic effect of contrast media. In patients and dogs diastolic compliance is significantly increased 5 minutes after the injection of contrast medium. After 10 minutes however in the dogs compliance is significantly decreased. Analysing left ventricular function by repeated ventriculographies one has to take into account that the function is altered by the first angiogram. The degree of the changes depends on the initial hemodynamic conditions and on the time interval between the ventriculograms.

Angiocardiography↗
PubMed1976

[Influence of nitroglycerin on hemodynamics, wall tension and oxygen consumption of the left ventricle].

The effects of nitroglycerin on left ventricular hemodynamics were determined in ten patients from biplane cineventriculograms and simultaneous pressure measurements. Before and after nitroglycerin (1.6 mg sublingually) the following parameters were measured: Systolic (PLV) and enddiastolic pressure (PLVED), enddiastolic (EDV) und endsystolic volume (ESV), cardiac output (SV), ejection fraction (EF) and ejection rate (ER), ejection time (tej), heart rate (HR), dp/dtmax, dp/dtmax Pi-Ped, maximal systolic wall stress (sigmamax), integrated systolic wall stress (sigma), outflow resistance (Rsys) and ventricular compliance (a). Nitroglycerin leads to a reduction of both, pre- and afterload, with a significant fall of PLV (10.8%), PLVED (21.8%), EDV (9.1%) ESV (13.3%) AND Rsys (14.4%). The changes of ventricular pressure and geometry result in a diminution of left ventricular wall stress (sigmamax- 11.8%, sigma - 26.4%), representing a decrease of calculated total oxygen-consumption of 11.5%. In six patients with reduced left ventricular diastolic compliance nitroglycerin leads to a remarkable increase of the compliance. This is probably due to the reversal of a latent ischemia by the decreased myocardial oxygen-consumption.

Adult↗
PubMed1975

[Intra-aortic balloon pumping in cardiogenic shock after cardiac surgery (author's transl)].

The results of intra-aortic balloon pumping in 7 patients with cardiogenic shock after cardiac surgery are reported. 2 patients were unresponsive to IABP, 4 patients showed initial stabilization of the circulation, but became IABP-dependent and died. One patient could be weaned from IABP, but died of uncontrollable cardiac arrhythmias. These results are discussed.

Adolescent↗
PubMed1975

[Estimation of ventricular volume derived from three transverse diameters and the longitudinal axis, compared with an area-longitudinal axis method (author's transl)].

The difficulty of automatic volume estimations of the left ventricle from cine-ventriculography lies in the accurate definition of the ventricular contour during the whole of the cardiac cycle. On the other hand, automatic determination of the long axis of the ventricle, and of three transverse diameters, is feasible. An attempt was therefore made to see whether accurate ventricular volume estimations could be obtained from these measurements. Two different geometrical models were examined: a) A complete rotational ellipsoid b) A half rotational ellipsoid. Examination of ten cine-ventriculograms (totalling 546 frames) has shown that the ventricular volume can be determined with an adequate accuracy by this method. The half ellipsoid model produced better mean results than the full ellipsoid. Its mean deviation from the area-long axis method was only minus 1.2%, that of the complete ellipsoid was minus 3.3%.

Heart Function Tests↗