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Biomedical subjects

P Southorn

Publications and source records attributed to P Southorn.

7 recordsLinked to original sources
PubMed1983

Sedation and respiratory mechanics in man.

The effects of sedation with halothane, enflurane or midazolam on respiratory mechanics and lung volumes were studied in young healthy volunteers, in the supine position. Functional residual capacity increased with halothane sedation, but was unchanged with sedation produced by enflurane or midazolam. Sedation with halothane and enflurane, but not midazolam, tended to increase lung static recoil pressure. Total lung capacity was decreased during sedation with midazolam. No evidence was found that sedation with these three agents increased airway resistance. These findings imply that changes in respiratory mechanics induced by the residual effects of anaesthetic agents are unlikely to contribute significantly to the impairment in pulmonary gas exchange which may occur in the period immediately after operation.

Adult↗
PubMed1980

Halothane anesthesia and respiratory mechanics in dogs lying supine.

Functional residual capacity (FRC) and quasi-static deflation pressure-volume (PV) curves of the total respiratory system, lung, and chest wall were measured in eight trained dogs lying supine, first awake and then anesthetized with halothane. Two of the eight dogs were repetitively examined 10 times during a 15-mo period. FRC decreased with anesthesia in six of the eight dogs and incresed with anesthesia in the remaining two dogs. There was a significant mean anesthesia-induced reduction in FRC of 16.9% (P < 0.05). FRC change with anesthesia varied between studies in one of the two dogs repetitively examined. Mean PV curves of the total system, lung, and chest wall of the six dogs whose FRC decreased with anesthesia were shifted to the right by anesthesia. PV curves from the two dogs whose FRC increased with anesthesia were shifted to the left. Anesthesia produced a significant reduction (P < 0.05) in mean lung compliance and significant increases (P < 0.05) in mean chest wall and total system compliances.

Anesthesia, Inhalation↗