Treatment of severe Pseudomonas infections often calls for multidrug therapy. Combinations of aminoglycosides, beta-lactams and/or quinolones are generally administered, the effect of which may be additive, synergistic or indifferent. The present in vitro study was designed to find out the exact outcome of the postantibiotic effect (PAE). The minimal inhibitory concentrations and the PAE of three antibiotics (amikacin, ceftazidime and ciprofloxacin) were determined both singly and in combination. Ceftazidime alone exhibited a negative PAE but a synergistic effect was observed for the combination of ceftazidime with amikacin. The combination of ceftazidime with ciprofloxacin and ciprofloxacin with amikacin however gave an indifferent PAE. This synergistic PAE of amikacin with ceftazidime has a significant effect on designing optimal dosage regimens.

Amikacin↗

PubMedDate not supplied

Passive smoking, domestic fuels and lung function in north Indian children.

A study was carried out in 200 school children from north India to find out the effects of passive smoking and exposure to domestic cooking fuels on their lung functions. Forced vital capacity and FEV1 were the lowest in boys whose households used biomass fuel (p < 0.05) and PEFR and FEF 25% and 50% were lowest in boys with their homes using kerosene as fuels. All these were the best for LPG fuel. However, in girls there was no significant difference in different parameters, although the values were lower in those using kerosene and biomass fuel. All parameters were lower in passive smokers irrespective of the type of fuel used although they were not statistically significant. However, FEF 50% was significantly less in passive smokers whose households used mixed fuels. The same was true for PEFR, PEFR %, and FEF 25% in cases of LPG fuel use.

Air Pollution, Indoor↗