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Biomedical subjects

P Slezak

Publications and source records attributed to P Slezak.

At least 55 records · Page 3Linked to original sources
PubMed1984

Flow-cytometric DNA analysis as a means for early detection of malignancy in patients with chronic ulcerative colitis.

A new approach to the problem of monitoring patients with chronic ulcerative colitis is presented and discussed in connection with a case report. When annual colonoscopies are performed, biopsies are taken for histopathological examination and DNA measurements are made using flow-cytometric techniques (FCM). Using the latter approach, gross chromosomal aberrations indicating malignant transformation in a cell population may be detected. In a 46 year old man with a long history of ulcerative colitis, an area with slight mucosal dysplasia at light microscopy was accompanied by two aneuploid cells lines - that is, colonic mucosa cells with an abnormal amount of DNA in the nuclei. An operation one year later revealed a 5 X 2 mm large adenocarcinoma in the corresponding area of the colon. We suggest that flow-cytometric techniques can be used as a complement to already practised methods for monitoring the colorectal mucosa in colitic patients for the early detection of malignancy.

Adenocarcinoma↗
PubMed1982

The effect of prostaglandin E2 on duodenal ulcer healing.

Oral prostaglandin E2 (PGE2) has specific protective effects so called cytoprotection on the gastrointestinal mucosa that are independent of the acid secretion. This has recently been documented in man. A clinical study was performed to test whether this mucosal reinforcing property also could be used to accelerate duodenal ulcer healing. Twenty-eight patients with endoscopically confirmed duodenal ulcers were randomized to treatment with PGE2 0.5 mg three times daily and 1 mg at night or to placebo under double-blind conditions during a four week period. To reduce antacid consumption a fluid placebo antacid was given regularly. An active antacid could be used for pain relief. Healing rate was assessed with repeated endoscopies after 2 and 4 weeks. The treatment groups were comparable with respect to age, duration of ulcer history and present ulcer symptoms, smoking habits, family history, gastric acid secretory rate and number of patients with blood group 0. There was a slight difference in sex distribution. 2 mg PGE2 did not reduce pentagastrin-stimulated acid secretion in five of the patients. After the treatment significantly more in the PGE2-group (12/14, 86%) had healed than in the placebo-group (6/14, 43% P less than 0.05). There was no difference in pain relief between PGE2 and placebo-treated. The antacid consumption was very low in both PGE2 and placebo-treated. No significant side effects or changes in laboratory test-results were recorded. It is suggested that the cytoprotective effect of PGE2 can be used to accelerate healing of duodenal ulcer.

Administration, Oral↗
PubMed1982

Non-dysplastic villous changes in endoscopic biopsies in ulcerative colitis with carcinoma.

Three cases of long-standing ulcerative colitis and invasive adenocarcinoma are described. In all three cases, pre-operative rectal and/or colonoscopic biopsies demonstrated the presence of a villous adenoma: two without dysplasia and the third with moderate dysplasia. The presence of structures compatible with villous adenoma should be, even in the absence of epithelial dysplasia, an indication for panproctocolectomy in patients with long-standing ulcerative colitis.

Adenocarcinoma, Mucinous↗
PubMed1982

The histological classification of early gastric cancer (micro-invasive carcinoma of the stomach).

During a 3.5-year period, January 1976 to June 1979, eleven cases of micro-invasive carcinoma of the stomach (early gastric cancer) were detected in 45 gastrectomy specimens having a pre-operative diagnosis of gastric carcinoma. The histological types found in the surgical specimens were highly differentiated (1), moderately differentiated (4), poorly differentiated (3) adenocarcinomas, one specimen had undifferentiated carcinoma, and in the remaining two cases mixed types were found. Multiple lesions were present in five specimens. In ten of the eleven specimens, focal cystic dilatation of the deeper part of the gastric glands were found in areas overlapped by micro-invasive carcinoma and/or in areas overlapped by mucosa showing chronic inflammation. The frequency of cystic dilatation of the gastric gland was much lower in specimens from patients with gastric or duodenal peptic ulcers. Thus, focal cystic dilatation present in negative gastric biopsies should be reported, thereby alerting the referring physician as to the possibility of a gastric malignancy.

Adenocarcinoma↗
PubMed1977

Thorotrast-induced renal tumours after retrograde pyelogram.

Seven cases of 'thorotrast kidney' after retrograde pyelogram with reflux are dealt with. In five instances cancer of the kidney developed, four of them obvious renal pelvic carcinoma between 14 and 41 years after the thorotrast pyelogram. In some cases the contrast deposits were misinterpreted and in one case the follow-up was also inadequate. There is a high risk of malignancy to connection with 'thorotrast kidneys'. These cases should be follewed up with intravenous pyelogram and exfoliative cytology from renal pelvis. Provided these tests are negative, nephro-ureterectomy should be put off.

Adenocarcinoma↗
PubMed1976

The incidence and clinical importance of hysterographic evidence of cavities in the uterine wall.

Filling of cavities in the uterine wall during hysterography was observed in 54 of 320 surgically excised specimens in which metal threads had been inserted at different levels for identification. Adenomyosis may have accounted for these cavities in 24%. Cavities secondary to adenomyosis in one part of the uterus coexisted when cavities not etiologically related to the disease in another part. Adenomyosis is generally not involved in the pathogenesis of cavities in the lower half of the uterus and does not account for cavities of more than 5 mm in diameter.

Adult↗
PubMed1975

A case of lymphoma with T-cell characteristics.

This case report concerns a woman of 54 who died from a rapidly progressive lymphosarcoma-cell leukaemia with the terminal complication of toxoplasmosis. The grossly atypical lymphosarcoma cells were shown to form rosettes with sheep erythrocytes but were incapable of responding to stimulation with phytohaemagglutinin. They thus had the functional characteristics of abnormal T-cells. The proportion of immunoglobulin-bearing lymphocytes was greatly reduced.

B-Lymphocytes↗
PubMed1975

Hysterographic evidence of polypoid filling defects in the uterine cavity.

According to earlier studies, radiographic evidence of polypoid filling defects in the uterine cavity has a physiological background if hysterography is carried out during the secretory phase of the menstrual cycle, but if performed during the proliferative phase, the defects indicate endometrial hyperplasia. This view was not confirmed in the present investigation. Of 8,000 hysterograms reviewed, 200 (2.5%) showed filling defects. Of these, 162 hysterograms were from cases in which the coexisting histological appearance of the endometrium was available; 78% of the histological examinations showed no abnormalities. There was no difference between the secretory and proliferative phases in this respect, and no correlation between radiographic evidence of polypoid filling defects and abnormal uterine bleeding.

Adolescent↗
PubMed1967

Intrafetal gas.

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Blood Vessels↗