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Biomedical subjects

P Sleight

Publications and source records attributed to P Sleight.

At least 235 records · Page 13Linked to original sources
PubMed1978

Arousal and the circadian rhythm of blood pressure.

1. We have recorded ambulant intra-arterial blood pressure in five normo- and 14 hyper-tensive subjects over 24 h, particular attention being paid to the time of arousal. 2. The data were edited beat-by-beat before storing systolic, diastolic, and mean blood pressure +/- SD for every 2 min period on a computer file. 3. When pooled hourly mean data are plotted there is a rise of 52.9 mmHg systolic and 22.3 mmHg diastolic pressure from 03.00 hours to 11.00 hours in the 14 hypertensive subjects. 4. When the data are plotted in 20 min periods for the hours before and after arousal it is clear that the major rise in pressure occurs abruptly at that time. The 2 h period before arousal shows only a small rise in pressure, i.e. 6.9 mmHg systolic and 2.9 mmHg diastolic. 5. It is suggested that the apparent rapid early morning rise of blood pressure is an artifact of the method of analysis.

Arousal↗
PubMed1978

Critical assessment of diagnostic value of endomyocardial biopsy. Assessment of cardiac biopsy.

Right or left ventricular endomyocardial biopsy with the Konno or the Olympus bioptome was attempted in 73 patients aged 5 months to 61 years, with 82 per cent success. Light and electron microscopy showed non-specific features in over half the biopsies with new or diagnostically useful information in only 10 per cent of cases, usually as a result of electron microscopy. The method is safe but is of strictly limited diagnostic value and is likely to be of most help as a research tool in the biochemical study of cardiomyopathies.

Adolescent↗
PubMed1976

Clinical trial of the beta-adrenoreceptor-blocking agent tolamolol with the use of 24 hour blood pressure recordings.

1. The average blood pressure over 24 h and its variability were measured in eight unrestricted subjects before and after commencing therapy with a new beta-adrenoreceptor-blocking agent, tolamolol. 2. The drug caused a fall of 15 +/- 6 mgHg in mean arterial pressure and heart rate fell by 13 beats/min. The variation in blood pressure and heart rate over 24 h was unchanged after treatment.

Adult↗
PubMed1976

Blood pressure variability in patients on beta-blockers.

The direct arterial blood pressure was monitored over 24 hours in unrestricted untreated patients in order to obtain the average pressure and standard deviation over 24 hours. The standard deviation was taken as the index of variability of pressure. In eight subjects the study was repeated three months after commencement of treatment with a beta-adrenergic blocking agent (tolamolol, 300 mg/day). In these subjects tolamolol resulted in a fall in mean blood pressure from 107 to 92 mmHg (P less than 0-05) and a fall in heart rate from 82 to 70 beats per minute (P less than 0-01). The variability in blood pressure, however, was unaffected by treatment.

Adrenergic beta-Antagonists↗
PubMed1975

Sleep and blood pressure.

Direct arterial pressure was recorded continuously over 24 hours in 18 totally unrestricted people (six normotensives, four untreated hypertensives, and eight treated hypertensives). There was an almost equal fall of about 20% in both systolic and diastolic blood pressure during sleep in the three groups when compared with their waking pressures. This fall in pressure was greater than that observed previously in patients sleeping in a laboratory or hospital. Furthermore, it suggests that hypertensive subjects do not have a higher centrally-induced vasoactive component and that hypotensive drugs do not alter the pattern of blood pressure behaviour induced by sleep.

Adult↗
PubMed1975

Carotid baroceptor re-setting in the hypertensive dog.

1. The behaviour of forty-four single carotid baroreceptor fibres from nine dogs with normal blood pressure was contrasted with that of forty-seven single fibres from nine dogs with renal (nephrectomy--clip) hypertension. 2. It was found that in response to a square-wave pressure step, the mean steady-state threshold pressure was 99.23 mmHg for the normotensive dogs and 129.13 mmHg for the hypertensive dogs. 3. The degree of re-setting appeared to correlate with the duration of the hypertension but was not seen until an animal had been hypertensive for more than 4 days. 4. In one animal, hypertensive for 7 weeks but whose blood pressure returned towards normal after removal of the clip, the receptor characteristics was normal. 5. No change in the gain of the receptor sensitivity was seen. 6. Light-microscopy and electron miscroscopy of the opposite (non-perfused) carotid sinus revealed no differences in the fibre morphology or density between the hypertensive and normotensive animals (a random sampling, four normal and six hypertensive).

Animals↗
PubMed1975

Continuous recording of direct arterial pressure in unrestricted patients. Its role in the diagnosis and management of high blood pressure.

We have compared casual indirect measurements of arterial pressure obtained 1) by the general practitioner (GP) and 2) in the outpatient clinic (OPC) with 24 hour continuous recording of direct arterial pressure in two selected group of unrestricted patients. 1) Eight asymptomatic, untreated patients with suspected hypertension. 2) Eight asymptomatic, treated patients whose indirect pressure readings seemed inappropriately high when considered against a general absence of target organ damage. Both groups showed that usually there was good agreement between arterial pressure recorded indirectly by GP and OPC while continuous recording showed wide variability of systolic and diastolic pressures over 24 hours and a significant fall during sleep. The first groups with suspected hypertension showed that the indirect measurements were not significantly different from the 24 hour direct recording. The second group of patients on treatment for hypertension showed a discrepancy, the direct readings being significantly lower than the indirect. This difference (approixmately 30 mm Hg mean arterial pressure) would explain the lack of target organ damage and may have been due to the effect of exercise augmenting the hypotensive action of drugs or due to a well developed defense reflex which biased the indirect readings.

Adult↗