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Biomedical subjects

P Slater

Publications and source records attributed to P Slater.

At least 163 records · Page 9Linked to original sources
PubMed1969

Hypothermia following intraventricular injection of hemicholinium-3 in rats.

1. In unanaesthetized rats, a dose of 50 mug of hemicholinium-3 injected into the cerebral ventricles produced a prolonged hypothermia which was unaffected by the simultaneous administration of choline. This suggests that it was not due to inhibition of acetylcholine synthesis.2. An intraperitoneal injection of 50 mug of hemicholinium-3 also produced hypothermia which, however, was blocked by choline which suggests that it is due to inhibition of acetylcholine synthesis.3. Hyoscine and hexamethonium did not block the hypothermia produced by intraventricular hemicholinium-3, but some antagonism was obtained with phentolamine, imipramine and amphetamine.4. When hemicholinium-3 was administered intraventricularly to rats pretreated with desmethylimipramine, a lethal hyperthermia developed.5. It is concluded that no central cholinergic mechanism is involved in the hypothermia of the rat resulting from an intraventricular injection of hemicholinium-3.

Acetylcholine↗
PubMedDate not supplied

Characteristics of 125I-Bolton-Hunter labelled cholecystokinin binding in human brain.

The high affinity binding of 125I-Bolton-Hunter labelled CCK-8 (125I-BHCCK) was studied in human brain using ligand binding and autoradiographic techniques. High levels of 125I-BHCCK binding were observed in cortex, striatum and cerebellum. In cerebellar membranes 125I-BHCCK binding was inhibited by CCK analogues with an order of potency, caerulein greater than CCK-8 greater than CCK-33 greater than gastrin 1-17 = CCK-8 non-sulphated. CCK-4 was inactive. It is suggested that in human brain 125I-BHCCK labels a population of CCK receptors similar to those observed in guinea pig brain. The properties and distribution of these receptors differ from those of rat brain.

Aged↗
PubMedDate not supplied

Autoradiographic localization of binding sites for galanin and VIP in small intestine.

The distribution of the binding sites for [125I]galanin and [125I]iodotyrosyl VIP in sections of small intestine from rat, rabbit, guinea pig and man was investigated using in vitro receptor autoradiography. The specific binding sites for [125I]galanin were most concentrated in the myenteric plexus and longitudinal muscle layers. The distribution of [125I]VIP binding was similar, with the highest level of binding in the myenteric plexus. Some VIP binding was also seen in the mucosa. The abundance of binding sites for both peptides in the myenteric plexus suggests that this is the anatomical site of the functional antagonism between these endogenous peptides in the mammalian intestine.

Animals↗