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Biomedical subjects

P Six

Publications and source records attributed to P Six.

At least 37 records · Page 2Linked to original sources
PubMed1982

[Radioimmunoassay of serum digoxin levels. Clinical exploration (author's transl)].

This work undertakes, in a second part, the clinical exploration of 947 serum digoxin levels of 281 hospitalized patients on a cardiology ward. Our results which coincide with those of other researchers, have led us to draw certain practical conclusions: the posology is determined first of all according to kidney function, weight and age of the patient. When the treatment is insufficient or on the other hand, poorly tolerated, a serum digoxin level is performed permitting thus: 1) in the case of ineffective treatment: to be sure of the patient's cooperation, to increase the posology if the serum digoxin level is not in the toxic zone, to discover an eventual pharmacokinetic problem; 2) to establish the responsibility of digitalis (when there are signs of intolerance or of intoxication), in case of arrhythmia, in patients with pacemakers, when associated drugs are capable of causing similar adverse effects; 3) to better manage a digitalis treatment in a high risk patient (unstable renal function, advanced myocardial disease, chronic obstructive disease).

Adult↗
PubMed1981

[Estimation of visco-elastic parameters of the bronchial system based on measurements obtained by dynamic tracheobronchography].

Visco-elastic parameters of the bronchi system are represented by the viscous modulus and the recoil static pressure. In several generations, values of the cross-sectional area of the bronchi are defined at various moments by the results obtained with dynamical tracheo-bronchography. By means of these measures and the use of a model describing the air flow in elastic bronchi, a calculation procedure of the visco-elastic parameters has been established.

Bronchi↗
PubMed1981

[Radioimmunoassay of serum digoxin levels. Clinical exploration (author's transl)].

This work undertakes, in a second part, the clinical exploration of 947 serum digoxin levels of 281 hospitalized patients on a cardiology ward. Our results, which coincide with those of other researchers, have led us to draw certain practical conclusions: the posology is determined first of all according to kidney function, weight and age of the patient. When the treatment is insufficient or, on the other hand, poorly tolerated, a serum digoxin level is performed permitting thus: 1) in the case of ineffective treatment: to be sure of the patient's cooperation, to increase the posology if the serum digoxin level is not in the toxic zone, to discover an eventual pharmacokinetic problem; 2) to establish the responsibility of digitalis (when there are signs of intolerance or of intoxication), in case of arrhythmia, in patients with pacemakers, when associated drugs are capable of causing similar adverse effects; 3) to better manage a digitalis treatment in a high risk patient (unstable renal function, advanced myocardial disease, chronic obstructive disease).

Age Factors↗
PubMed1980

[Phenacetin abuse II. Chronic renal insufficiency in Basle autopsies].

The frequency of chronic terminal renal failure (CTRF) (serum creatinine greater than or equal to 4,5 mg/dl) in an unselected autopsy material was about 1.7% from 1968 to 1976. Based on this figure, the estimated yearly incidence is 160 to 200/10(6) inhabitants of the Basel area. In inhabitants of Basel, analgesic nephropathy (42.2%) was the most important cause of CTRF (excluding obstructive nephropathy). Pyelonephritis (without evidence of analgesic abuse) represented only 25.7%. All other nephropathies were less common: glomerulonephritis 14.6%, diabetic nodular glomerulosclerosis 11.6%, cystic kidney disease and vascular nephropathies (each 4.5%). By contrast, in patients treated by hemodialysis and renal transplantation glomerulonephritis (28.7%) is the most important cause of CTRF, followed by analgesic nephropathy (20%), pyelonephritis (15%) and cystic disease of the kidney (12.5%). The difference between the two groups can be explained by the lower mean age of patients treated by hemodialysis and transplantation. Incidence and disease course can be affected significantly only in analgesic nephropathy. It is therefore very important to prohibit legally the use of phenacetin or paracetamol containing analgesics without medical prescription. In addition, these drugs should be replaced by other analgesic compounds.

Adult↗
PubMed1980

Polyendocrine deficiency syndrome. Occurrence in a patient with depressed IgA titers receiving phenytoin.

A 35-year-old woman had an addisonian crisis and primary adrenal, ovarian, and thyroid failures were detected. Antibodies against the adrenal glands and the thyroid were found, together with consistently low IgA levels. The patient had been receiving phenytoin, a drug known to induce an IgA deficiency, for 20 years. The question arises as to whether this substance was responsible for an immunological defect leading to an autoimmune process that damaged the adrenal glands, the ovaries, and the thyroid.

Addison Disease↗
PubMed1979

Chemical and enzymic degradations of nucleoside mono- and diphosphate sugars. I. Determination of the degradation rate during the glycosyltransferase assays.

In incorporation experiments used for the determination of glycosyltransferase activities, we demonstrated that the nucleoside diphosphate sugars are decomposed in three different ways: 1, transfer of the monosaccharide to acceptor molecule, catalyzed by glycosyltransferases; 2, degradation of the glycosyl nucleotides by nucleotide pyrophosphatase into monosaccharide 1-phosphates which are further hydrolyzed into free monosaccharides by phosphatases; 3, chemical decomposition of UDP-D-[14C]Gal; UDP-D-[14C]Glc and UDP-D-[14C]GlcUA into 1,2-cyclic phosphate derivatives of the corresponding monosaccharide. All the breakdown products of the nucleoside mono- and diphosphate sugars which are obtained during the incorporation experiments may be separated by paper chromatography and their amounts may be determined. Galactosyltransferase assays on human and rat serum have shown that the three different ways of decomposition of the nucleoside diphosphate sugars are dependent mostly on the concentration of divalent cations (Mn2+, Mg2+). Inhibition of the nucleotide pyrophosphatase activity is obtained with low concentrations of UMP, but increasing concentrations of UMP inhibit also the galactosyltransferase activity and consequently enhance the formation of galactose 1,2-monophosphate. A partial elimination of the nucleotide pyrophosphatase activity was achieved by the addition of increasing concentrations of UDP-D-Gal. These results demonstrate that the determination of glycosyltransferase activities in tissues and in biological fluids is not possible without a concomitant determination of the nucleotide pyrophosphatase activity present in the assay.

Adult↗
PubMed1979

[Comparison of algorithms for the resolution of a secular equation in the vibrational analysis of biological molecules].

A computer analysis of several solution methods for secular equations leads to a determination of their optimum conditions. The results contribute to the application of a new preliminary method of frequency assignment to the vibrational study of the heavy atoms coordination sphere in complex biological structures, such as metalporphyrins and adenosine triphosphate.

Adenine Nucleotides↗
PubMed1978

[Autoimmune polyendocrinopathy with IGA deficiency].

Case report of a 35-year-old female patient who was admitted in Addisonian crisis and in whom primary adrenal, ovarian and thyroid failure was detected. Antibodies against the adrenals and the thyroid were found, together with dinished serum IgA levels. The patient had been treated for 20 years with diphenylhydantoin, a drug known to induce immunological disturbances, e.g. depression of serum IgA levels. The IgA deficiency and pluriglandular failure may be due to prolonged therapy with diphenylhydantoin. The coincidence of IgA deficiency and autoimmune diseases is well known. As far as is known this is the first case of IgA deficiency associated with autoimmune polyendocrinopathy.

Addison Disease↗
PubMed1977

[Piribedil, dopaminergic agonist. Prolonged clinical and electrophysiological study in 60 parkinsonian patients (author's transl)].

Sixty cases of Parkinson's disease were treated with piribedil alone (dose : 274 mg/day, duration : 20,4 months). The overall clinical improvement, confirmed by recordings of tremor and EMG, was 34%, tremor being improved of 59%. Before treatment, an intravenous test does of piribedil with recording made it possible to predict the effectiveness of oral treatment. Side-effects (vasomotor, digestive, psychiatric) were moderate. Orthostatic hypotension, dyskinesia and fluctuations were exceptional. The basic indication for piribedil lies in forms of recent onset in which tremor predominates, patients in whom L-dopa is contraindicated and a certain number in whom the latter has failed (tremor, fluctuating action).

Administration, Oral↗
PubMed1977

[Thiamine, riboflavine and pyridoxine supply in chronic alcoholism (author's transl)].

Tests on 50 chronic alcoholics demonstrated that there was a reduced supply of thiamine (measured with the transketolase activation test) and riboflavine (glutathione reductase test) compared with results obtained in 1152 healthy controls. A high risk of thiamine deficiency was present in 45.4% of male and 50% of female alcoholics; risk of riboflavine deficiency was 11.1% and 16.7%, respectively. Corresponding results in the normal controls were 2% for thiamine and 0.4% for riboflavine deficiency. There was a significant relationship between enzymatic values of thiamine deficiency, on the one hand, and anaemia, abnormal liver functions (bilirubin, gamma-globulin) and low diastolic arterial pressure, on the other. Enzymatic riboflavine values also correlated with haemoglobin content, so that it is assumed that the anaemia is associated with the reduced thiamine or riboflavine supply. Enzymatic determination of pyridoxine with the GOT activation test would seem to be influenced by alcohol or by metabolic processes induced by it and is therefore not suitable in the presence of chronic alcoholism.

Adolescent↗
PubMed1977

Interaction study between phenprocoumon and flurbiprofen.

The effects of flurbiprofen on various coagulation and haemostasis parameters were studied in 19 patients adequately anticoagulated on a fixed dose of phenprocoumon. Laboratory controls were performed 5 times at weekly intervals. Flurbiprofen 50 mg 3-times daily was given for 2 weeks after an initial control period of 2 weeks. The last control followed 1 week after cessation of flurbiprofen. All changes observed during the administration of flurbiprofen were quantitatively moderate; some reached statistical significance. The prothrombin time (%) Factor II and Factor X values fell; Factor II values remained unchanged. Factor IX values fell only in the first week on flurbiprofen and reached control values thereafter. Phenprocoumon concentration remained constant throughout. There was no change in spontaneous platelet aggregation. Although there was a slight, statistically significant increase in the Ivy bleeding time, it remained within the normal range. These findings suggest that the interference of flurbiprofen with oral anticoagulation is minimal and probably of no clinical relevance.

4-Hydroxycoumarins↗
PubMed1976

[Vitamin B 1 deficiency in chronic alcoholics and its clinical correlation].

50 chronic alcoholics reporting to the medical emergency ward of Basle University Hospital with alcohol-related illness were examined with respect to thiamine nutritional status by means of the transketolase activation test of erythrocytes (ETK). 46% of the chronic alcoholics, compared to only 2% of the control population (1152 healthy adults), had transketolase activation quotients indicating a strong probability of thiamine deficiency (alphaETK greater than 1.25). The most important symptoms associated with the biochemical parameters of thiamine deficiency were: anemia, pathologic liver functions (bilirubin, gamma-globulins), low diastolic blood pressure and Wernicke's encephalopathy. There was a statistically significant correlation (p less than 0.05) between these symptoms and the biochemical parameters for thiamine deficiency. Therefore, when treating chronic alcoholics, these symptoms should direct attention to a possible vitamin B1 deficiency. Since the enzymatic vitamin B1 parameters correlate with the patients' hemoglobin, our results would be consistent with anemia influenced by provision of thiamine.

Adult↗