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P Sipponen

Publications and source records attributed to P Sipponen.

At least 199 records · Page 11Linked to original sources
PubMed1984

[Gastritis and stomach cancer--epidemiologic correlation].

This association between chronic gastritis and gastric carcinoma has been reasonably well established, however the nature of this association is still not clear and is probably very complex. Thus the intestinal type of carcinoma shows a higher prevalence and more rapid than expected progression of atrophic gastritis in the antrum and body, and the available evidence suggests that atrophic gastritis with metaplasia and dysplasia precedes the occurrence of signs of malignancy. In the diffuse type, however, no direct relationship can be demonstrated between gastritis and gastric carcinoma. On the other hand, the diffuse type of gastric carcinoma, too, shows some association with atrophic gastritis in that the histochemical characteristics of diffuse carcinoma cells are as a rule similar to those of the surrounding epithelium. Thus the intestinal type of gastric carcinoma seems to be directly and the diffuse type more likely only morphogenetically related to atrophic gastritis.

Chronic Disease↗
PubMed1984

Prevalence of gallstones in Finland: an autopsy study in the Helsinki area.

The prevalence of gallstones in Helsinki (Uusimaa county) was determined in an autopsy sample consisting of 1102 males and 768 females. The crude prevalence of gallstone disease in men was 15.3%, as compared with 34.5% in women. The age-adjusted rates for men and women were 8.7% and 15.9%, respectively. The prevalence of gallstone disease appears to be significantly lower in Finland than in Sweden. However, cholecystectomy rates appear to be higher in Finland than in reports from Sweden and Norway. No significant association with neoplastic disease was found.

Adult↗
PubMed1984

Progression of antral and body gastritis in patients with active and healed duodenal ulcer and duodenitis.

The dynamics of the antral and body mucosa has been studied in biopsy specimens obtained during endoscopy of patients with duodenal ulcer (103 cases), patients with duodenal ulcer scars (108 cases), and patients with duodenitis (44 cases). A representative Finnish population sample consisting of 434 subjects was used as reference material. The antral mucosa of all patient series showed an increase in the severity and prevalence of gastritis similar to that of the general population, whereas virtually no progression of gastritis with age was seen in the body mucosa, which remained normal or at the stage of superficial gastritis up to geriatric age. In contrast, in the present controls and in all earlier population samples studied by us so far, there was a significant and steady increase in the severity and prevalence of body gastritis with age. It is concluded that the age behavior of the antral and body mucosa was in duodenal ulcer scars and duodenitis similar to that of patients with active duodenal ulcer. The persistence of normal conditions in the acid-secreting area may serve as one explanation of the strong tendency of the disease to recur. In addition, it is tentatively concluded that in duodenal ulcer disease there are factors that have a 'protecting' influence on the body glands and which are abolished by antrectomy, according to our earlier studies.

Duodenal Ulcer↗
PubMed1983

Atrophic chronic gastritis and intestinal metaplasia in gastric carcinoma. Comparison with a representative population sample.

The occurrence of chronic gastritis and intestinal metaplasia (IM) was studied in 257 patients with gastric carcinoma (GC). In all cases biopsies were available from the benign mucosal area adjacent to the tumor, and in 139 patients from the antrum and/or body mucosa outside the tumor. The results were compared with endoscopically and bioptically examined noncancer controls representing a large Finnish population sample. For every GC patient, a control subject was matched by age and sex. In addition, a mean age-adjusted score (AAS) of chronic gastritis, which expresses the progression of gastritis in GC patients as compared with that in the general population, was calculated for GC patients. The prevalences of chronic and atrophic gastritis in the antrum and body mucosa were similar in GC patients and controls when carcinoma cases were not more specifically classified according to histologic type or location of tumors. On the other hand, the location of the tumor showed a significant relation to gastritis: the progression of gastritis was more rapid (high mean AAS value) and the prevalence of atrophic gastritis was higher in the tumor-affected area (i.e., in the antrum in patients with antral [distal] tumors; in the body in patients with body [proximal] tumors), than in the general population, but were similar in the tumor-free area in both GC patients and controls. In the intestinal type of GC (IGC), the prevalence of chronic gastritis was higher and its progression was more rapid than in controls. In the diffuse type of GC (DGC), these correlations were less distinct. In GC patients, the IM adjacent to and outside the tumor area was significantly more common and extensive than in the corresponding area of controls, and a significant positive correlation was present between the location of the tumor and the distribution of IM. Like gastritis, the IM showed a closer relationship to IGC than to DGC. In all cases of GC and particularly of IGC, the antral mucosa tended to be more severely affected by gastritis and IM than the body mucosa, i.e., the prevailing type of gastritis found in this GC series was that morphologically corresponding to the so-called B-type of chronic gastritis.

Age Factors↗
PubMed1983

Cystic 'hamartomatous' gastric polyps: a disorder of oxyntic glands.

In 1977, Elster et al. described gastric polyps of a new type. These polyps were formed of fundic glandular cysts in otherwise normal gastric mucosa. In this paper a series of 52 cases of this type of polyp are presented. In addition to cysts, polyps contained deformed oxyntic glands and areas where the formation of secondary irregular glands occurred from cysts and from the existing glands. However, all glands and cysts in polyps were composed of normal, but intermixed cells of oxyntic type, suggesting that deranged differentiation of otherwise normal oxyntic glands is the basic mechanism in the pathogenesis of these polyps. Based on these observations, the polyps were considered most likely to be epithelial hamartomas. In agreement with the findings of Elster et al., the present cases showed typical clinical characteristics: three-quarters of patients were females with a peak prevalence in the fifth and sixth decades. Polyps were most often multiple and occurred only in the oxyntic mucosa of the stomach.

Adult↗
PubMed1983

Uninterrupted prolonged ethanol oxidation as a main pathogenetic factor of alcoholic liver damage: evidence from a new liquid diet animal model.

Marked fatty infiltration and degenerative or mild inflammatory changes including eosinophilic cytoplasmic degeneration in centrilobular cells and focal inflammatory changes with cell necrosis were observed in livers of rats maintained for 12 weeks on a nutritionally adequate and balanced liquid ethanol diet. The animals continuously oxidized ethanol due to the supplementation of the diet with a low dose of 4-methylpyrazole (4-MP, an alcohol dehydrogenase inhibitor), that decreased ethanol elimination by about 20%. In other, equicalorically pair-fed groups of rats receiving (a) a similar ethanol-containing liquid diet without 4-MP or (b) a diet with 4-MP and 20% less ethanol, only a few minor changes were seen. The liver histology of rats pair-fed a control diet with a 4 times higher doses of 4-MP was completely normal. The results indicate that the prolonged imbalance of hepatic metabolism due to the uninterrupted oxidation of ethanol is a crucial factor in the development of alcoholic liver injury.

Animals↗
PubMed1983

The gastric mucosa in stomachs with polyps: morphologic and dynamic evaluation.

Biopsy specimens from the antral and body mucosa of 183 patients with gastric polyps (adenoma, 4; hyperplastic polyp (HP), 52; foveolar hyperplasia (FH), 49; and inflammatory polyp (IP), 78 cases) have been examined. The prevalence of gastritis in the series was compared with that in 183 age- and sex-matched controls. The dynamics (progression) of gastritis was evaluated by means of an age-adjusted gastritic score. In the HP and FH groups the prevalence and progression of body gastritis were significantly higher and more rapid (p less than 0.001) while the prevalence of antral gastritis was lower (p less than 0.05) and its progression less rapid (p less than 0.001) than in controls. It is concluded that the pernicious anaemia type of gastritis (A-type gastritis) is closely related to gastric polyps of hyperplastic origin. The progression of this gastritis type seemed to increase in the order IP, FH, and HP. In addition, we observed an increase in the prevalence of intestinal metaplasia (p less than 0.001) and marked epithelial dysplasia (0.1 greater than p greater than 0.05; chi-square = 3.75) in stomachs with polyps as compared with in controls.

Adenoma↗
PubMed1983

Age behaviour of gastric acid secretion in males and females with a normal antral and body mucosa.

In males with a normal gastric mucosa the acid secretion expressed in terms of fat-free body weight (FFB) shows a random distribution with age, whereas in females there is a significant increase. To explain this sex-related discrepancy, we examined maximal pentagastrin-stimulated gastric acid output (AO) and the parietal cell density (P) and thickness (T) in 50 males and 50 females with a normal antral and body mucosa randomly collected from a representative Finnish population sample. Two alternatives were considered: 1) the parietal cell reactivity remains constant, and the age variation in females is due to an increase in the total parietal cell mass, 2) the age variation in females is due to an increase in the reactivity of parietal cells, the total parietal cell mass (P X T X body area (A)) remaining constant. Starting from the first alternative, P and T were measured and showed no correlation with age in males and a decrease in females. The variable A is, according to the formula, expressed by the ratio AO/P X T, and this ratio shows an expected significant correlation with AO in both males and females. However, the variable A showed a significant increase with age in females but not in males. In view of the results of Cox that A should not vary with age, the present results suggest that the ratio AO/P X T in females must include, in addition to body area, other variables, such as the reactivity of parietal cells.(ABSTRACT TRUNCATED AT 250 WORDS)

Adult↗
PubMed1983

Gastric mucosal erosions. An endoscopic, histological, and functional study.

Gastric erosions were detected in 404 patients in an elective gastroscopic series of 3837 patients. One hundred and seventeen patients with predominant erosion findings were examined in detail, and the results compared with those of age- and sex-matched controls. No difference was observed between patients and controls with regard to antral and body gastritis. The complete (type I) erosions were different from the other erosion types. They were more often located in the body mucosa (p less than 0.001), and foveolar hyperplasia (p less than 0.025) and hyperplastic polyps (p less than 0.01) and characteristics of A gastritis in the surrounding mucosa were common. The erosion patients had a higher acid secretion capacity than the corresponding controls (p less than 0.005), but with regard to the type of erosion, only the patients with incomplete (type IIb) erosions differed statistically significantly from the corresponding controls (p less than 0.005).

Adult↗
PubMed1983

Morphology and dynamics of the gastric mucosa in duodenal ulcer patients and their first-degree relatives.

The prevalence of antral and body gastritis was determined in 30 duodenal ulcer patients and in 143 of their first-degree relatives, and compared by conventional mathematical and stochastic analyses with data on gastritis in a representative Finnish population sample. For conventional analysis, the controls for the duodenal ulcer patients and for the duodenal ulcer relatives, were matched for age and sex. For stochastic analysis, the duodenal ulcer patients and their 99 siblings were compared with the total control population of 434 subjects. The prevalence of gastritis affecting mainly the antral mucosa, and both antral and body mucosa to a similar extent was significantly higher in duodenal ulcer patients than in both controls and in relatives. The prevalence of antral and body gastritis in DU relatives and their controls was similar. However, the prevalence of subjects with normal antral and body mucosa was significantly lower. Stochastic analysis revealed more rapid progression of antral gastritis with age in the duodenal ulcer patients than in their siblings or controls and less rapid progression of body gastritis. The overall progression of antral and body gastritis was similar in DU siblings and their controls, but a dichotomy in the mean antral gastritis score of DU sibships was found, indicating high and low antral gastritis liability subgroups. The mean score of DU sibships having a mean age of less than 50 years behaved dynamically like DU patients, while the mean scores of sibships with a higher mean age had a low liability to develop antral gastritis. Most duodenal ulcer siblings who themselves had a duodenal ulcer, ulcer scar or duodenitis were found in the "high antral gastritis liability" subgroup.

Adult↗
PubMed1982

Decreased prevalence of gallstones in gastric cancer.

The prevalence of gallstones and the frequency of previously performed cholecystectomy were examined in 498 autopsy subjects who had gastric cancer and their age- and sex-matched control subjects. The frequency of gallstones not treated by operation and previous cholecystectomy was significantly (p less than 0.01) lower in those with gastric cancer than in the matched-control subjects. It is not possible to determine on the basis of this study what the possible factors that cause this phenomenon are.

Adult↗
PubMed1982

Gastric polyps; their morphological and endoscopical characteristics and relation to gastric carcinoma.

In 13 200 consecutive gastroscopies polyp-like lesions were found in 454 patients and of these 425 were examined histologically. Tumours other than polyps were excluded and there remained 357 cases which were divided in four groups: adenoma (8%), hyperplastic polyp (34%), foveolar hyperplasia (21%) and inflammatory polyp (36%). Transitional forms between different groups were seen and sometimes characteristics of different polyptypes could be seen within one and same polyp. In addition, the mean age of the patients increased in order: inflammatory polyp, foveolar hyperplasia, hyperplastic polyp and adenoma, suggesting that the different groups are not separate entities but represent related stages in the morphogenesis of gastric polyps. 219 cases out of 357 patients were re-examined endoscopically on average 2.5 years after the first examination. This examination revealed new polyps in 26% of all cases and spontaneous disappearance of the polyps in 14% of cases suggesting that gastric polyps, particularly those of the hyperplastic and inflammatory type are in a dynamically labile state. Gastric carcinoma was found in 27 (8%) of patients with polyps. In 4 of these cases the carcinoma was found at the re-examination (which in 3 cases was performed within 0.5 and in 1 case within 1.5 year). In 14 cases carcinoma was found inside the polyps and in 6 of these carcinoma was "early" in its growth. In 13 cases carcinoma was found outside the polyps and in all of these carcinoma was "advanced". Carcinoma was found in 38% of adenoma cases and in 5% of cases with polyps other than adenomas.

Adenoma↗
PubMed1982

Epidemiology and dynamics of gastritis in a representative sample of an Estonin urban population.

The epidemiology and dynamics of gastritis were studied in a representative sample of an urban population of Estonia. The sample consisted of 227 subjects 15-69 years old who were examined by direct-vision endoscopic biopsy, and the data were subjected to dynamic evaluation by stochastic principles. The prevalence of antral gastritis (64%) was similar to but that of body gastritis (62%) higher than that in other population samples studied by us. Correspondingly, the prevalence of atrophic antral and body gastritis was high: 38% and 37%, respectively. The prevalence of atrophic gastritis in the antrum and body increased significantly with age. On the other hand, no sex dependence of gastritis could be demonstrated. The prevalence of gastritis mainly affecting the body (32%) was significantly higher in the present than in the other Estonian sample (19%) studied by us. Complete loss of normal body glands was found in 14 subjects, and in 8 of these the antrum was normal or only slightly altered (type A gastritis). The prevalence of gastritis mainly affecting the body increased significantly with age, whereas that of gastritis mainly affecting the antrum decreased. Dynamic evaluation disclosed two basic dynamic patterns similar to those found in other population samples: the age-specific prevalences of gastritis increased with age according to the Poisson process, and gastritis started in the antrum at a younger age, but its progression was more rapid in the body mucosa. Dynamically, the chief finding of the sample was markedly more rapid progression of the body gastritis than in other samples, which explains the high prevalence of gastritis mainly affecting the body mucosa (type A gastritis) in the present series.

Adolescent↗
PubMed1982

[Liver biopsy].

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Biopsy, Needle↗
PubMed1981

Lysozyme in neoplastic Paneth cells of a jejunal adenocarcinoma.

This is the first reported case in which neoplastic cells not of granulocytic or monocytic origin have been shown to contain lysozyme. A highly differentiated metastasizing adenocarcinoma of the jejunum is presented. Areas of the tumour contained cells resembling Paneth cells, that is, they contained cytoplasmic granules with 1) stained red with Masson's trichrome and 2) were shown to contain lysozyme by an immunoperoxidase technique. No argentaffin cells could be identified within the tumour. Staining of mucosubstance revealed large intestine-type sulfated glycoproteins in the tumour tissue. The presence of lysozyme-containing neoplastic Paneth cells suggests that the tumor: 1) originated from the mucosal crypts, and 2) had a high degree of cellular differentiation.

Adenocarcinoma↗
PubMed1981

Hepatic copper in primary biliary cirrhosis: biliary excretion and response to penicillamine treatment.

Excessive hepatic copper accumulation occurs in long-lasting cholestatic liver disorders especially in primary biliary cirrhosis. As in Wilson's disease, penicillamine has recently been introduced for the treatment of primary biliary cirrhosis. In Wilson's disease there is decreased biliary excretion of copper. The present study shows that as compared with controls the biliary excretion of copper is not decreased in primary biliary cirrhosis; instead it may be increased in some patients. However, when compared with high hepatic copper concentration biliary copper excretion was low. In contrast with copper, biliary secretion of bile acids was decreased in eight of the 17 patients. Treatment with oral penicillamine (600 mg/day) for one year resulted in a significant decrease of hepatic copper concentration, but had no consistent effect on the biliary excretion of copper or on the amount of histologically stainable orcein-positive copper-binding protein. The results suggest that excessive hepatic copper accumulation in primary biliary cirrhosis may not be primarily caused by a decreased biliary excretion, or that a new equilibrium is achieved in advanced primary biliary cirrhosis. D-penicillamine appears to improve significantly the biliary excretion of bile acids.

Adult↗
PubMed1981

Colonoscopy in the diagnosis of antibiotic-associated colitis. A prospective study.

Colonoscopic findings among 16 patients with histologically proved antibiotic-associated pseudomembranous colitis (PMC) were analyzed. The characteristic endoscopic changes of PMC with pseudomembranes were observed in only 5 (31%) out of 16 patients by sigmoidoscopy but in 11 (85%) out of 13 patients in whom colonoscopy was also performed. The findings suggest the importance of colonoscopy in the early diagnosis of PMC and indicate that the typical endoscopic changes of PMC are limited to the colon above the rectosigmoid area in most patients with antibiotic-associated colitis. It is emphasized that colonoscopy should be performed at least in clinically suspected PMC cases, in which the early diagnosis of PMC might be missed if sigmoidoscopy alone is performed.

Adult↗