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Biomedical subjects

P Singer

Publications and source records attributed to P Singer.

At least 235 records · Page 13Linked to original sources
PubMed1978

The triglyceride fatty acid pattern in arterial wall, adipose tissue and serum of amputated diabetic subjects.

The triglyceride fatty acid pattern [TFAP] in arterial wall, adipose tissue and serum has been estimated in diabetic subjects by gas-liquid chromatography simultaneously. The samples were taken shortly before or during femoral amputation performed under halothane anaesthesia. In addition, in some probands the fatty acids of cholesterol esters of vascular walls have been obtained. The following differences in the TFAP of the tissues under study were discovered. In arterial wall compared to serum, lauric, myristic, myristoleic, palmitoleic, stearic, oleic and linolenic acid were increased; palmitic and linoleic acid were decreased, whereas eicosatrienoic, arachidonic and eicosapentaenoic acid were at the same level. In arterial wall compared to adipose tissue, myristic, palmitic and nervonic acid were decreased; eicosatrienoic, arachidonic and eicosapentaenoic acid were increased. Most differences concern the TFAP of adipose tissue compared to serum: lauric, myristic, myristoleic, palmitoleic, oleic, linolenic, lignoceric and nervonic acid were elevated in the former; palmitic, linoleic, eicosatrienoic, arachidonic and eicosapentaenoic acid were increased in the latter. In consideration of different content of fatty acids in the tissues studied the authors conclude that certain fatty acids have distinct metabolic positions such as depot fatty acids and precursors of prostaglandins.

Adipose Tissue↗
PubMed1977

[Polycythaemia as sole symptom of renal adenoma (author's transl)].

In two children, a 9 year-old boy and a 10 1/2 year-old girl, who presented with polycythaemia as the only symptom, the expected renal tumour was only found after exclusion of all other causes of polycythaemia. The delay in diagnosis was caused by technically inadequate intravenous urograms, which were erroneously passed as normal. In one child low kv X-ray exposition of the kidneys led to the diagnosis of a renal tumour. In the other child high-dose urography and tomography gave the indication for selective angiography. Normalization of the red blood count postoperatively verifies the connection between preoperative erythrocytosis and the renal tumour. Histologically both cases proved to be renal adenomas, which are extremely rare in childhood.

Adenoma↗
PubMed1977

[Diagnosis of primary hyperlipoproteinemias].

The diagnostics of hyperlipoproteinaemias is essentially based on the proof of biochemical parameters. The simultaneous determination of triglycerides and cholesterol in the serum is the most important measure for establishing disturbances of the lipid metabolism. The behaviour of these two lipids, the consideration of the serum and the lipoprotein electrophoresis in most cases make possible a classification according to the distributed all over the world and clinically relevant division according to Fredrickson. Loading tests for the early recognition of hyperlipoproteinaemias - analogus to protodiabetes - are hitherto not yet known. Within the diagnostics shoude be taken into consideration that hyperliproproteinaemias are frequently associated with other metabolic diseases (obesity, gout, diabetes mellitus, hypertension) as so-called metabolic syndrome.

Cholesterol↗
PubMed1977

The fatty acid composition of triglycerides in arteries, depot fat and serum of amputated diabetics.

The triglyceride fatty acid pattern (TFAP) in arterial wall, adipose tissue and serum in vivo has been estimated in amputated diabetic subjects by gas-liquid chromatography simultaneously. Besides, in some probands the fatty acid pattern of cholesterol esters of vessel walls has been obtained. In arterial wall the percental content of lauric, myristic, myristoleic, palmitoleic, stearic, oleic and linolenic acid was high and that of palmitic and linoleic acid was low, when compared to serum, whereas eicosatrienoic, arachidonic and eicosapentaenoic acid were of similar magnitude. In comparison to adipose tissue myristic, palmitic and nervonic acid were decreased and eicosatrienoic, arachidonic and eicosapentaenoic acid were increased in arterial wall. In view of the results the speculation is obvious that certain fatty acids have distinct metabolic positions in several tissues, such as depot fatty acids and precursors of prostaglandins, for example.

Adipose Tissue↗
PubMed1976

[Metabolic alkalosis and secondary hyperaldosteronism in cystic fibrosis (author's transl)].

The prolonged use of a salt restricted infant formula (1.9 mEq Na/kg/day and 1,4 mEq C1/kg/day) in a child with undiagnosed cystic fibrosis led to a life threatening metabolic disturbance. The main features were hypochloraemic alkalosis due to massive loss of electrolytes in the sweat. Urinary electrolyte excretion, however, had been lowered to a minimum due to aldosteron induced reabsorption. Plasma aldosterone levels were initially high, but returned to normal after addition of salt to the feeds. Prior to admission a sweat test had been negative. The patient clearly demonstrates the unique metabolic feature of cystic fibrosis of the ability to retain electrolytes in the tubulus and at the same time the inability of the sweat glands to reabsorb sodium and chloride. Contrary to present experience severe prolonged salt restriction is believed to be able to diminish sweat electrolytes to subpathological values.

Aldosterone↗
PubMed1975

[Diabetic coma as a task for intensive therapy].

On the basis of 763 cases with diabetic coma from 1960 to 1973 is referred to the advantages of the foundation of a coma ward as department of intensive observation. It is reported on some successful changes of therapy in recent years. The introduction of methods of intensive therapy has led to a significant decrease of lethality. A sufficient administration of potassium (not less than 200 mval/die) and the prevention of a cerebral oedema are actual demands for the improvement of the prognosis of diabetic coma.

Berlin↗
PubMed1975

Physical basis of charge pairing in mitochondria.

The postulate of charge pairing in the mitochondrial inner membrane is justified by applying a formula due to Fuoss to calculate the probability density for the distance between a positive and a negative charge. For dielectric constants 10 or less pairing is absolute, for 20 there is some tendency towards pairing, and at 78 it is nonexistent. Pairing, partner exchange or charge substitution, inhibition, and antiport uncoupling can be rationalized within this framework.

Computers↗