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Biomedical subjects

P Simpson

Publications and source records attributed to P Simpson.

153 records · Page 9Linked to original sources
PubMedDate not supplied

Determinants of aerobic capacity during exercise following complete repair of tetralogy of Fallot with a transannular patch.

Exercise capacity and the causes of its limitation following repair of tetralogy of Fallot have been studied in heterogeneous populations. Study populations have been grouped together regardless of the type of repair and residual hemodynamic abnormalities. To better understand the factors limiting aerobic exercise capacity in patients repaired with a transannular patch, 37 patients with a transannular patch and no residual pulmonary stenosis underwent resting spirometry and treadmill exercise testing. Maximal oxygen consumption and oxygen consumption at anaerobic threshold were measured in all patients to assess aerobic capacity. Patients were subdivided by gender. Resting spirometry measurements tended to be lower in both genders compared to healthy controls but did not correlate with any measurement of aerobic capacity. Maximal oxygen consumption and anaerobic threshold were significantly less in the female than the male population. A quadratic relation between maximal oxygen consumption and age at exercise testing existed for both genders but peaked at an earlier age and was significantly less in the female population. There was a significant negative correlation between maximal oxygen consumption and echocardiographically estimated right ventricular inflow volume index in the female population only. These data suggest that in patients with tetralogy of Fallot repaired with a transannular patch aerobic capacity is limited primarily by cardiac function, but that gender differences are due to noncardiac causes.

Adolescent↗
PubMedDate not supplied

Exercise performance following repair of hypoplastic left heart syndrome: A comparison with other types of Fontan patients.

Reports of exercise performance after Fontan surgery for hypoplastic left heart syndrome (HLHS) are lacking. We compared the exercise performance of total cavopulmonary connection type (TCPC) of Fontan subjects with HLHS (group 1, n = 7) to those not requiring a Norwood procedure having a systemic right ventricle (group 2, n = 6) or a systemic left ventricle (group 3, n = 8). The subjects underwent assessment of resting pulmonary mechanics followed by maximal exercise testing with a bicycle or treadmill protocol. ECG, oxygen consumption, and carbon dioxide production were measured continuously. There was not a significant difference seen between HLHS and the comparison groups for the following parameters: maximum heart rate, maximum oxygen consumption, respiratory exchange ratio, breathing reserve, and arterial oxygen saturation at rest or exercise. Exercise performance in the TCPC type of Fontan patients was comparable regardless of ventricular morphology or surgical approach.

Case-Control Studies↗
PubMedDate not supplied

Choosing a cell fate: a view from the Notch locus.

During the development of Drosophila melanogaster, individual cells must make choices between a restricted set of possible fates in order to give rise to spatial patterns composed of different types of differentiated cells. The Notch locus appears to play a central and general role in the regulative events that control the local architecture of the final cellular pattern in several tissues, among them being the central and peripheral nervous systems.

Animals↗
PubMedDate not supplied

Intra-arterial pressure monitoring. An alternative technique using winged needles.

The use of 21 gauge winged needles for direct arterial pressure monitoring is described. The results obtained with this technique compare favourably with those obtained from direct cannulation of major vessels. The use of winged needles sometimes makes arterial cannulatiin possible when other, more conventional, methods may fail.

Adult↗
PubMedDate not supplied

Patient and family perspectives on early discharge and care of the older adult undergoing fractured hip rehabilitation.

PURPOSE: To examine the impact of enhanced early discharge on families experiencing repaired hip fracture in an older adult. DESIGN: Qualitative. SAMPLE: Convenience sample of 23 care recipients over the age of 60 years who had experienced a hip fracture and their caregivers. METHODS: Families were interviewed 4 to 6 weeks postdischarge from the hospital. Prior to the interview a questionnaire designed to measure intra-family strain was mailed to the main caregiver. The resulting narratives were analyzed for recurring themes. FINDINGS: A high number of clients and their families experienced a high degree of mismatched care, especially in relation to care received by nursing staff. This perception was not influenced greatly by location (i.e., hospital or community) and was exacerbated during periods of transition. CONCLUSION: Heightened communication involving clients and families, especially during transition from hospital to home, may lessen family/client perceptions of mismatched care. IMPLICATIONS FOR NURSING RESEARCH: Communication methods, role clarification of the professional nurse, and the ability to provide more holistic care during transition phases of health care are areas that need to be explored and developed.

Adult↗