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Biomedical subjects

P Simon

Publications and source records attributed to P Simon.

736 records · Page 41Linked to original sources
PubMedDate not supplied

[Hepatic amebiasis in French Polynesia. 16 cases in 2 years].

Asymptomatic amebiasis in known for long ago in French Polynesia; the presence of Entamoeba histolytica cyst carriers have been shown by several parasitological investigations. But, until now, no hepatic amebiasis case has been reported in this geographical area. An homogeneous series of 16 cases of hepatic amebiasis is reported here. The diagnosis was made by hepatic ultrasonography and confirmed by immunology (Indirect immunofluorescent tests gave always a positive reaction for a dilution of 1/512 or more). Clinical, biological and radiological signs are well known in tropical pathology. Therapy was always conducted with metronidazol by the authors. From the epidemiological point of view, 14 out of 16 cases come from Tuamotu Archipelago. This epidemiological fact appears important enough to carry out systematically hepatic ultrasonography and amebic++ serology for every patient evacuated from this Archipelago to Tahiti. Hence it must be kept in mind the possibility of hepatic amebiasis not only in people living in French Polynesia but also, for the ones coming from over there but living in France.

Adolescent↗
PubMedDate not supplied

[Antidepressive effects of 3 endogenous monoamines: psychopharmacologic profiles of noradrenaline, octopamine and phenethylamine].

Norepinephrine (NE), octopamine (OA) and phenethylamine (PEA) are easily destroyed by M.A.O. but we could show, even injected intraperitoneally that they are active upon tests used generally to reveal an "antidepressant" effect. This effect is especially studied by using antagonism of apomorphine, reserpine, oxotremorine-induced hypothermia. The psychopharmacological spectra of NE and OA are close to the one of salbutamol and the observed effects correspond to alpha- and beta-adrenergic stimulations. The PEA spectrum is similar to the one of amphetamine and the observed effects correspond to adrenergic stimulations and to a dopaminergic stimulation. The mechanisms involved in the tests realized to show an "antidepressant" effect could reflect an activity not only through endogeneous NA but also possibly through endogeneous OA and PEA.

Animals↗
PubMedDate not supplied

[Unexpected interactions of some psychotropic drugs with barbital and pentobarbital effects in mice (author's transl)].

Some of the substances studied modified the effects of the two barbiturates as expected and in the same direction: --chlorpromazine and diazepam increased the effects; --amphetamine and caffeine decreased them. Barbital, unlike pentobarbital, undergoes almost no metabolic transformation. This explains why pentobarbital is potentiated in the presence of proadifen, an inhibitor of liver microsomial enzymes, whereas the effect of barbital is unchanged, and probably explains similar results obtained with iproniazide and imipramine. For the same reason, rifampicine, an enzyme inducer, antagonizes the effect of pentobarbital without affecting that of barbital. The dissociated effects obtained with other substances are more difficult to explain: --increased effects of barbital without modification of the effects of pentobarbital (sulpiride); --decreased effects of barbital without modification of the effects of pentobarbital (methylphenidate, nomifensine, amineptine, oxolinic acid, methysergide); --decreased effects of barbital with increased effects of pentobarbital (viloxazine). Two hypotheses may be considered: 1. The study of barbital and pentobarbital concentrations in blood and brain would allow to exclude a pharmacokinetic interaction; 2. Barbital does not act through the same mechanism as pentobarbital.

Amphetamine↗
PubMedDate not supplied

[Which surgery for which breast cancer?].

After a brief historical presentation, the two more commonly realized surgical procedure developed in the surgical treatment of breast cancers are described. The relative indications for the mastectomy and the conservative surgery (tumorectomy and quadrantectomy) are explained in different clinical situations.

Breast Neoplasms↗