Search PubMed⌕ Search

Biomedical subjects

P Simon

Publications and source records attributed to P Simon.

At least 577 records · Page 32Linked to original sources
PubMed1976

[Amnesia induced in rats by benzodiazepines in a non-painful situation].

During their first exposure to a non-familiar situation, food deprived rats eat only for a short time. During their second exposure, the rats eat for a longer time. Rats treated with benzodiazepines before their first exposure showed no enhanced food intake during the second exposure. This effect did not seem related to an acquired taste aversion but more likely could be explained by an impaired retention of the first experience.

Amnesia↗
PubMed1976

Interaction of atropine or methylatropinium with four effects of two cholinergic drugs.

In mice, pilocarpine - or oxotremorine - induced decrease in locomotor activity and increase of the reaction time to pain were antagonized by atropine and not by methylatropinium. Identical doses of atropine and methylatropinium suppressed the antagonism of the cholinergics towards reserpine-induced palpebral ptosis. Cholinergics-induced hypothermia was not clearly antagonized by atropine or methylatropinium.

Animals↗
PubMed1976

Antagonism by sulpiride of three apomorphine-induced effects in rodents.

Three effects of apomorphine (hypothermia and climbing behavior in mice, stereotyped behavior in rats) were studied. Sulpiride antagonized the two effects in mice but stereotyped behavior in rats remained unchanged. Pimozide and haloperidol antagonized the three effects. These results could be explained by the existence of two types of dopaminergic receptors or by the different accessibility to identical dopaminergic receptors located in different CNS areas.

Animals↗
PubMed1976

[Tranquilizers. Pharmacologic aspects].

An inventory was made of the various substances utilized as minor tranquillizers in man. Throughout the various methods of study of these drugs in animals the main pharmacological properties of tranquillizing drugs were considered. Attention is drawn on the various secondary or adverse effects of minor tranquillizers.

Animals↗
PubMed1976

Pathogenesis of Woronoff ring in psoriasis.

As a result of ultraviolet light and coal tar therapy, a white ring (Woronoff) may develop in the normal skin adjacent to psoriatic plaques. Injection of prostaglandin E2 (PGE2) 1 cm outside of Woronoff ring produced redness in the ring, demonstrating that vessels within the ring were not unresponsive to PGE2. Whole skin homogenates from Woronoff ring contained an inhibitor of prostaglandin synthesis that was not found in uninvolved skin that was obtained from either psoriatics or normal controls. Prostaglandin E2 levels in the ring were one third of those in uninvolved skin from either psoriatics or normal controls. These findings suggest that the white ring that surrounds ultraviolet-light-treated psoriatic plaques is produced by a local inability to synthesize PGE2 in response to an ultraviolet light stimulus, resulting from the presence of an inhibitor of prostaglandin synthesis.

Coal Tar↗
PubMed1975

[Effects of diazepam on six drug-induced locomotor hyperactivities in mice (author's transl)].

Experiments were carried out in mice to investigate the influence of diazepam (DZP) on dexamphetamine, parachloro-N-methylamphetamine (pCMA), cocaine, morphine, trihexyphenidyl or (in MAOIs pretreated) reserpine induced motor hyperactivity. The interaction of DZP with these hyperactivities in which probably different biochemical central mechanisms are involved allows to construct a profile of action of DZP and to approach its mechanism of action. The locomotor hyperactivities induced by dexamphetamine, pCMA, morphine, cocaine were not reduced by DZP even by doses which decrease spontaneous locomotor activity; low doses of DZP enhance the hyperactivity induced by these compounds. Those induced by trihexyphenidyle or by reserpine (after MAOI) were reduced by DZP at doses which produce no decrease in spontaneous motor activity. Inasmuch as DZP at low doses potentiates the effects of 4 different substances, the results can hardly be satisfactorily explained neither by an interference of the benzodiazepine on the metabolism of the drugs or by a depression of the anxiogenic action of dexamphetamine. Even though it may be difficult to relate the antagonism of DZP on trihexyphenidyl- or on reserpine- (after MAOI) induced motor hyperactivity to the suggested anticholinergic and dopaminergic actions of DZP, these effects may partly be involved in the increase in locomotor hyperactivity induced by dexamphetamine, morphine, or cocaine. The observed effect of DZP on pCMA induced locomotor hyperactivity does not support a possible antiserotonine action often suggested to explain the effects of benzodiazepines in conflict situations.

Animals↗
PubMed1975

[Effects of antianxiety drugs on the food intake in trained and untrained rats and mice (author's transl)].

Various minor tranquilizers (benzodiazepines, barbiturates and meprobamate) induced an increase in the food intake of rats or mice. Drugs were injected i.p. 30 min before testing and the amount of food consumed during 30 min was recorded. The enhanced food consumption occurred when the animals were in a novel situation, in a situation which they had previously experienced, or in their home cage, in which they were used to eating in the daytime within 30 min. Studies with two benzodiazepines showed this effect to be maximal between 10 to 30 min after injection and to disappear 4 hrs after injection. Moreover, minor tranquilizers reduce the latency before eating of rats and mice tested in a new situation. These results and the observation of anti-anxiety drugs-induced hyperphagia in satiated animals suggest that: 1. The enhanced food consumption of a non familiar food in a novel situation induced by the minor tranquilizers could hardly be related only to their anti-anxiety action. 2. The existence of some inhibitory controls (endogenous satiety in daytime or satiety after recent absorption) is not essential for the action of the minor tranquilizers. 3. An increased motivation and a disruption in the food related behavior could possibly be an explanation for all the observed effects.

Amobarbital↗