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Biomedical subjects

P Simon

Publications and source records attributed to P Simon.

At least 541 records · Page 30Linked to original sources

[Pharmacological profile of the main psychotropic drugs: place of nomifensine (author's transl)].

Numerous methods of experimental psychopharmacology can be used. They help to draw up the profile of a new drug and then to compare this profile to those of the main reference drugs. This predictive psychopharmacology gives good results when the new substances is closing resembling already existing substances, but is more difficult with new substances. The most used tests are presented and more precisely those which are particularly used for antidepressants study. The profile of nomifensine ressembles that of the classical antidepressants but has two clear different characteristics: presence of a stimulant component and lack of anticholinergic activity.

Animals↗

[Predictive studies in psychopharmacology (author's transl)].

Once the efficacy of a drug has been proven (by controlled trials), it may be interesting to define "responder" and "non-responder" profiles. This can be done with a non-comparative prediction trial in which initial (pre-treatment) characteristics of subjects with good or poor result are compared, or with a randomized trial in which one attempts to define initial features of favorable or unfavorable cases, which could lead later to a better choice for a future given patient between these therapies (and only these ones) given in similar conditions. Predictor variables can be: demographic, physiologic, nosologic, symptomatic. Statistical methods can be: simple comparison of responses between sub-classes according to one initial feature, or multivariate techniques particularly discriminant analysis (when results are expressed in a dichotomic way), multiple regression (when responses are graded, as with an improvement score). Validation of results of such trials can be done by checking their predictive value on subjects independant of those from which prediction algorithms have been set up.

Adult↗

[Methodology of a cooperative study of response predictors in ambulatory depressive syndrome treated with nomifensine].

A multicentric therapeutic survey on ambulatory depressive patients has been designed so as to get data allowing response-prediction. The protocol included:--selection of non psychotic ambulatory depressive patients--one month's treatment with nomifensine--collection of data consisting mainly in a series of visual analogue scales, scored by a phisician and given in several random orders to avoid error of proximity. Data treatment indluded:--a step of checking and codification--the study of relations between global appraisal and characteristics of subjects--the study of initial profile of responders and non-responders, using discriminant analysis and correspondance factorial analysis.

Ambulatory Care↗

[Perhexilline maleate: relationship between side-effects, plasma concentrations and rate of metabolism (author's transl)].

In three individuals (2 male and 1 female) with severe side-effects apparently related to the regular ingestion for a period of at least 5 months of perhexiline maleate, the authors studied the rate of fall in plasma levels of the drug, of its monohydroxylated metabolite, blood transaminase and glucose levels following the interruption of therapy. The relationship between these data would indicate two hypotheses which could be tested during future studies: the manner in which the body metabolises the drug would appear to vary in relation to plasma concentration and/or hepatic involvement.

Adult↗

Imipramine antagonism of apomorphine-induced hypothermia: a non-dopaminergic interaction.

Imipramine antagonized high dose apomorphine-induced hypothermia, and did not modify small dose apomorphine-induced hypothermia. It is suggested that apomorphine-induced hypothermia is the result of two effects. The first, induced by small doses of apomorphine, and antagonized by pimozide and sulpiride, is probably related to dopaminergic receptor stimulation. The second, induced by high doses of apomorphine, and antagonized by imipramine, is probably not related to dopaminergic receptor stimulation.

Animals↗

Standard and long-acting depot neuroleptics in chronic schizophrenics: an 18-month open multicentric study.

The overall objective of this 18-month open study was to compare standard neuroleptics and long-acting depot neuroleptics following the current psychiatric practice in order to determine the best therapy. Thirty French psychiatrists from 15 different wards participated in this experiment. One hundred eighty-one chronic schizophrenic patients were randomly assigned to receive one of the following three treatments: standard neuroleptics, pipotiazine palmitate, or fluphenazine decanoate. Criteria used for evaluation were an overall clinical evaluation by a psychiatrist, a Brief Psychiatric Rating Scale, and a Nurse's Observation Scale for Inpatient Evaluation. No significant difference (P greater than .05) was observed between the three groups in drug effectiveness or tolerance.

Adult↗

[Models of inhibition in animal behavior].

The concept of inhibition in psychopharmacology is discussed by presenting different models of behavioral inhibition in animals. The inhibitions induced by fear or anxiety appear as a result of punishment introduction into an unknown situation, frustration... These inhibitions are particularly sensitive to minor tranquilizers. The inhibitions induced by "fatigue" appear when avoidance situations continue for 24 hours or when a situation demands a marked increase of animal activity to obtain the same reward (food). These inhibitions are particularly sensitive to psychoanaleptics. The inhibition induced by placing a animal in an inescapable situation is particularly sensitive to antidepressants.

Animals↗

[Use of evaluation scales in psychopharmacology].

Rating scales are used to assess the intensity of psychiatric attributes such as anxiety and depression: they are generally composed of several items to be rated. They postulate: the continuity of the "measured" attribute; a monotonic attribute-item scores relationship; and the cancellation, within the final score of "parasitic" factors due to other features than the one which it is desired to measure. The main metrologic qualities are: sensitivity to states of different intensities, reliability in respect to time and rater, validity: relative to an external clinical classification, to another rating scale, or to known efficacy of a treament on the studied attribute. Self-rating scales avoid an intermediate rater and are easy to use. But they allow for no interpretation from external information, and cannot be used in patients with linguistic difficulties, or severely impaired. Scales rated by a rater consist of codification of a well-conducted interview. They allow for correction of erroneous answers from the patients. They may be affected by certain systematic rater errors (attenuation, central or extreme tendency, halo effect, etc...) which are decreased by training. The global score can be obtained by summing item scores, or from a factor analysis. Construction of a rating scale is a difficult task which implies a series of approximations to obtain, from an initial collection of items, satisfactory metrologic qualities. Translation and adaptation of a rating scale are difficult manoeuvres, which may jeopardize its validity.

Evaluation Studies as Topic↗