[Parsonage-Turner syndrome after cytomegalovirus infection].
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Biomedical subjects
Publications and source records attributed to P Seror.
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This study, in 13 control subjects, assesses the normal value of the centimeter conduction delay (CCD). The mean CCD is 0.184 ms, the maximum CCD is less than 0.40 ms and the ratio between maximum and normal CCD never exceeds 2. In 47 patients with clinical features of carpal tunnel syndrome and normal classical EMG data, the centimeter test selected two groups. The first consists in 32 patients with a pathological maximum CCD varying from 0.36 to 1.10 ms and a maximum to normal CCD mean ratio of 3.75. The second group consists in 15 patients with a maximum CCD between 0.21 and 0.39 ms and a maximum to normal CCD mean ratio of 1.52.
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In 5 to 10% of cases of carpal tunnel syndrome, the abnormalities of nerve conduction of the median nerve at the wrist remain too discrete for the diagnosis to be confirmed by classical electromyographic techniques. The centimetric test provides a very precise anatomo-functional analysis and studies nerve conduction, centimetre by centimetre, over a distance of 10 centimetres (11 recordings). The time taken by the sensory potential to travel 1 centimetre is referred to as the centimetric conduction time (CCT). The normal mean CCT is equal to 0.185 m.sec and the CCT is considered to be pathological when it is greater than twice the normal mean CCT or more greater than 0.40 m.sec on the first approximation. The use of the centimetric test in 45 cases of clinical suspicion of carpal tunnel syndrome in which classical electromyographic data were insufficient was able to confirm the diagnosis in 32 cases and exclude it in 10 cases. In 3 cases raising particular problems, the centimetric test was also very useful. The centimetric test allows an individual diagnosis in each of these cases, whereas the same conclusions could only be drawn from overall statistical analysis of the classical electromyographic data of the two populations. The centimetric test also localizes the origin of compression in these very limited forms to the lower edge of the flexor retinaculum of the carpus in more than 80% of cases.
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The wrist flexion test of Phalen has been studied in 127 patients with carpal tunnel syndrome and 20 control subjects, all of whom also had nerve conduction studies. There was a statistically significant relationship between the severity of electrical changes and the probability of a positive Phalen's test. However 34% of patients had a negative test and 20% of control subjects a positive one.
Fifty-eight cases of carpal tunnel syndrome confirmed by electromyography by combined studies of motor and sensory conduction of the median nerve at the wrist have been the subject of electrical studies to assess spontaneous changes and progress after treatment. Spontaneous progress in 9 cases showed an absence of changes in electromyographic findings in general and the possibility of definite improvement or rapid spontaneous worsening. Progress after local corticosteroid injections showed a statistically significant improvement after 1 to 2 months but they also showed an overall progressive return to the previous values in 6 to 12 months. Again, progress may be either clearly favourable or unfavourable. The injection seemed to alter the natural progress only very slightly. Only after operative treatment in 17 cases was there a very obvious and often rapid statistically significant improvement. This improvement was lasting and continued for at least up to a year.
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A positive Tinel's sign was found in 63% of patients with electrophysiologically proved carpal tunnel syndrome. However, Tinel's sign was also positive in 45% of control patients. It is therefore concluded that the sign is of no diagnostic value in individual patients with suspected carpal tunnel syndrome.
This study involved 100 cases of carpal tunnel syndrome defined according to current electromyographic criteria. This investigation compared electromyographic data, in particular the speed of sensory conduction in the median nerve in the wrist with 8 clinical criteria, age, the duration of the disorder, the incidence and painful nature of nocturnal paresthesia observed, the incidence of diurnal paresthesia, Tinel's sign, Phalen's test, and the test of hyperextension of the wrist. After comparing these findings, two conclusions may be drawn: the identification of high-risk patients, who are persons over 70 years of age and the existence of a statistically significant correlation between the speed of sensory nervous conduction and Phalen's test. All other criteria examined have no bearing in predicting the severity of median nerve compression.
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The anterior interosseous nerve syndrome is a rare entrapment neuropathy of the median nerve. It is a pure motor deficit characterized by pinch loss. Anterior interosseous nerve lesions are easily assessed by EMG. The data from literature being incomplete in a majority of cases (85%), we propose EMG criteria to assert the presence of an anterior interosseous nerve syndrome and to exclude other diagnoses. The study of the anterior interosseous nerve in 20 healthy patients shows that the difference in motor potential latency between the healthy and the non-healthy side is the most predictive stimulo-detection sign. Detection, however, remains the most important element for diagnosis.
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Two personal observations of febrile reaction to D-penicillamine in patients with rheumatoid arthritis provide the opportunity for recalling the clinical presentation which is fairly uniform. The physiopathological mechanism is still unknown. In Wilson disease, progressive reintroduction of the drug may be successful.
In 48 patients with osteoporosis and at least one vertebral fracture, the Singh vertebral index, which assesses the femoral trabeculation, was compared to the Meunier vertebral radiologic index, which is determined according to the number and severity of vertebral deformations. The femoral index was abnormal in all patients. However, the threshold level, set by Singh at Stage IV, which supposedly discriminates between subjects with and without osteoporosis could not be confirmed as one-third of the patients with at least one vertebral fracture were Stage V. A statistically significant correlation was found between the femoral index and the vertebral radiological index.