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Biomedical subjects

P Segond

Publications and source records attributed to P Segond.

48 records · Page 3Linked to original sources
PubMed1976

[Paget's disease with osseous demineralization (author's transl)].

Radiological diagnosis of Paget's disease which is based on hypertrophy of the osseous cortex, osteocondensation and a fibrillary appearance of the cancellous bone, can be rendered difficult when there is superadded demineralization. This is usual in the initial phase of the condition and take on the form of circumscribed osteoporosis. Such an appearance can however be misleading owing to its wide extent or to the number of localizations, as was the case in two of our cases; the diagnosis of Paget's disease must then be established from histological criteria. Besides this demineralization which is directly related to the morbid process in Paget's disease, calcium deficiency is known to modify the clinical and radiological symptomatology of Paget's disease. Our first two cases illustrate this fact and the remarkable effectiveness of "remineralization" therapy in such cases.

Aged↗
PubMed1975

[Acquired vertebral block with bone demineralization during Paget's disease].

The authors report an observation on a man 68 years of age suffering from Paget's disease in the pelvi-rachidian region. In four years the lumbar lesions evolved to form an L2-L4 vertebral block. The intensity of the bone radiotransparency of the vertebral block indicated some similarity to the localized forms of osteolysis well known in the skull and the long bones.

Aged↗
PubMedDate not supplied

[Presence of cryoprecipitates in the serum of patients with rheumatoid arthritis].

Serum samples from 140 controls (C) and from 72 patients suffering from defined rheumatoid polyarthritis (RP) were tested for cryoglobulins (CG). CG were found in 19.7 percent of C and 55 percent of RP : a highly significant difference (p less than or equal to 0.001). In the controls there was no correlation between the CG and age or sex. The RP with cryoglobulins seemed to have more inflammation, but systemic manifestations were not any more frequent than in the cryonegative RP. In the RP a correlation was noted between the presence of CG and the following parameters : increase in the sedimentation rate, rise in serum immunoglobulins, IgA and IgC, presence of antinuclear factors, and drop in the C4 fraction of complement. There was no correlation with the presence of the rheumatoid factor in the serum. In 33 cryoprecipitates in the RP, 7 contained IgG, 1 IgM, 22 IgM-IgG -- of which 11 contained C1q and 16 rheumatoid factor -- and 3 contained IgA-IgM-IgG -- of which 1 contained C1q and 2 rheumatoid factor. Some of the biochemical data support the hypothesis that likens these cryoglobulins to immune complexes.

Adult↗
PubMedDate not supplied

[Chronic constrictive pericarditis complicating an apparently stable rheumatoid arthritis. Report of a new case (author's transl)].

The authors report a case of constrictive pericarditis complicating an apparently stable sero-negative rhumatoïd arthritis, a rarely described pathological association. The patient had a serious polyserositis due to an extremely marked and inflammatory pericardial constriction. The rhumatoïd origin was confirmed by pericardial effusion, histological and immunofluorescent studies. The inflammatory pericardial process rendered pericardiectomy virtually impossible and resulted in a fatal outcome.

Adult↗
PubMedDate not supplied

[Mixed cryoglobulinaemia and benign monoclonal gammopathy in Sjogren's syndrome (author's transl)].

The authors report a case of Sjögren's syndrome associated with Raynaud phenomenon and mixed IgM-IgG cryoglobulinaemia. Three years after the onset of this association:--Immunoelectrophoresis of the serum showed a monoclonal IgM (lambda) protein, --the level of the mixed IgM-IgG cryoglobulinaemia had increased from 28 mcg/ml up to 12 mg/ml and its IgM component was monoclonal (lambda) with anti-IgG activity. Search for amyloïdosis and for a malignant lymphoma was negative. Such an association of a benign monoclonal gammopathy, mixed cryoglobulinaemia and Sjögren's Syndrome has only exceptionally been reported in the literature.

Aged↗
PubMedDate not supplied

[Long follow-up study of juvenile chronic arthritis (author's transl)].

The authors report a follow-up study of 24 patients who initially fulfilled ARA criteria for juvenile chronic arthritis (JCA). After an evolution period of 6 to 50 years, diagnosis was revised in three patients: one suffered from mixed connective tissue disease, another from psoriatic arthropathy and the last one from Crohn's disease. Among the 21 remaining JCA patients, 16 had still an inflammatory disease when last examined and 2 of these 16 died from amyloidosis. The articular involvement appears to be similar in systemic and polyarticular disease. The physical disability can be correctly appreciated only after a 10 years evolution period. Six patients were functionally classed in grade 4. Their loss of motility was due to hip or/and knee involvement. Five of them improved after complex orthopaedic surgery and the last could not undergo anaesthesia. Both articular involvement and the fact of the chronicity of illness account for psychological and social inaptitudes. Different therapeutics are appreciated and compared.

Adolescent↗