Biomedical subjects

P Schoening

Publications and source records attributed to P Schoening.

2 recordsLinked to original sources

PubMed1999

Cellulose and calcium lower the incidence of chemically-induced colon tumors in rats.

In a 30-week preliminary study and a follow-up 22-week study (2 x 2 factorial), dimethylhydrazine (DMH) injections effectively induced colon tumors in Fischer-344 rats. How this incidence of colon tumors might be affected by cellulose (preliminary study) or by calcium and folic acid (follow-up study) was examined. Cellulose in the diet appeared to provide some protection against DMH-induced colon tumors, but the protective effect of calcium was more evident; normal levels of calcium (500 mg per 100 g diet), but not of folic acid (0.1 mg per 100 g diet), provided protection against colon tumors. The effect due to calcium was observed whether viewed in terms of total number of tumors (p < 0.01) or number of tumors per tumor-bearing rat (p < 0.01).

Adenocarcinoma↗

PubMed1992

A method for publishing genomic maps.

We describe a method for the creation, manipulation and publication of physical human genome maps. Employing an "intelligent" document interface metaphor, our system uses a commercially available programmable document production system as an interface to primary genetic data resources and externally created mapping algorithms. Our document architecture distinguishes between primary data (usually obtained through database queries) and both manual and programmatic manipulations on these data. Our document architecture can be extended to accommodate a wide range of genetic and physical mapping problems. Because our approach is based on a widely available document preparation product, the principal focus of activity remains centered on the production of genomic maps that can be made available in a wide range of paper and electronic formats.

Algorithms↗