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P Sava

Publications and source records attributed to P Sava.

18 recordsLinked to original sources
PubMed1979

[Relationship between intestinal motility and absorption. Electromyographic study in the dog. (author's transl)].

The effects of different food components on intestinal motility were studied by means of an electromyographic technique. The electrical activity of the small intestine in the fasted state consists of a cyclic recurring phenomenon - the myoelectric complex - which is inhibited by feeding. The duration of inhibition of the myoelectric complex was shown to depend on the nature of the food components (glucose, peptides or lipids) as well as on the caloric load. In the opposite, the intensity of the intestinal motility was seen to depend only on the nature of the food components, and not on the caloric load. Thus, the duration of inhibition of themyoelectric complex can be considered as a consistent and objective parameter, which reflects the duration of the fed state.

Animals↗
PubMed1979

[Study on the effects of bromopride on intestinal peristalsis (author's transl)].

The effect of 4-amino-5-bromo-N-[2-(diethylamino)-ethyl]-2-methoxy benzamide (bromopride, Viaben) on the intestinal motility was studied in dogs. Highly sensitive transducers were implanted on the intestinal serosa, allowing to measure both electrical and mechanical impulses at the same point from the small intestine. These studies were performed in 5 dogs to which bromopride was administered in i.v. or i.m. doses of 10, 20 and 30 mg. The results of the studies were as follows: 1. Bromopride causes an increase in both the number and amplitude of the spikes; at the same time there is a significant increase in the number and amplitude of the intestinal contractions. 2. The average duration of the cycle of the myoelectric complex does not change. This indicates that bromopride has no effect on the normal cycle of motoric activity in the intestine. 3. Bromopride seems more effective in the fasted state than in the post-prandial phase. 4. The effect of i.v. infection is greater than that of i.m. injection and begins earlier.

Action Potentials↗
PubMed1978

Specific effects of different food components on intestinal motility. Electromyographic study in dogs.

Interdigestive intestinal myoelectric activity is characterized by repetitive aborally migrating complexes which are inhibited by feeding. The aim of the present work was to study the effects of different food components on the duration of inhibition of the myoelectric complex and on the number of spike potentials during this period. 4 dogs were prepared for chronic recordings with electrodes implanted on the jejunum and an alimentary cannula placed into the duodenum. Glucose, peptides and lipids were given into the cannula at doses of 7.5 and 15 kcal/kg. The results indicated that the inhibition of the myoelectric complex was longer for lipids than for glucose and even longer than for peptides. When the caloric load was increased, the duration of inhibition was also increased. As concerns the spike potentials, their number was increased after administration of glucose and of peptides, whereas it was decreased after lipids. Lastly, the increase of the caloric load did not change the number of spike potentials significantly. These results indicated that the duration of inhibition of the myoelectric complex depended on both the nature and the caloric load of the food components, whereas the number of spike potentials was determined only by the composition of food.

Action Potentials↗
PubMed1978

[Operative trauma of the common bile duct. Report of eight cases (author's transl)].

The authors report eight cases of operative trauma to the common bile duct; seven patients were sent up for reoperation often during the late stages following an attempt at immediate or secondary repair. Emphasis was placed on the interest of extensive resection of the stenosis and wide and high opening of the common bile duct for construction of the bilio-jejunal anastomosis, and furthermore the late risk of onset of portal hypertension requiring portacaval anastomosis, finally the possible degradation of the good initial results requiring difficult reoperations.

Adult↗
PubMed1978

[Intestinal motility after intraduodenal and intrajejunal feeding].

Post-prandial intestinal motility, analysed through two electromyographic parameters, duration of inhibition of myoelectric complex (DIMC) and percentage of spike potentials (PSP), was studied after ingestion of glucids, proteins and lipids. Post-prandial intestinal motility depends on both chemical nature and caloric load of nutriments: DICM depends on those two factors but PSP only depends on nature of nutriments. Post-prandial intestinal motility also depends on route of administration of nutriments. Intra-jejunal administration versus intra-duodenal administration increases DIMC observed for glucids and proteins, diminishes DIMC observed for lipids and diminishes PSP observed for glucids and proteins. These results indicate a specificity of intestinal post-prandial motility with characteristics of nutriments. Intestinal digestion and absorption of nutriments, just as hormonal secretion in response to intestinal passage of nutriments could explain such a specificity.

Action Potentials↗
PubMed1978

[Medullary carcinomas of the thyroid. General review apropos of 3 further cases].

The authors report of three cases of medullary carcinoma of the thyroid and, from a review of the literature, study the definition, frequency, embryological and etiological characteristics of this disease. The physiology of thyrocalcitonin, the concept of the APUD system the secretion of active substances by the tumour cells are considered. The macroscopic and microscopic characteristics and its mode of spread are described. The two main clinical forms, the sporadic form and the familial form are described together with the other endocrine involvements. Among the factors in positive diagnosis, accent is placed on per-operative histological examination and on biological tests of familial detection. Among the forms of treatment the essential place of surgery explains partly the relatively favourable course and prognosis of the malignant disease.

Adult↗
PubMed1977

[Study of intestinal motility. Contribution of electromyography].

The longitudinal and circular deformations of the intestinal wall have been studied simultaneously with the intestinal electrical activity. Tracings were obtained for several weeks by means of a compact device which was implanted on the jejunum in 6 dogs and 4 rabbits. The results showed that the transverse movements of the intestine corresponded to the muscular activity of the circular layer. The longitudinal movements were observed permanently in the rabbit. In the dog they could correspond to a contraction or a relaxation movement. In the two cases, no electrical activity was related to the longitudinal mechanical activity of the intestine.

Animals↗