34 medicated schizophrenic inpatients, 34 normal control subjects, 18 affective disorder patients (four in manic phase), nine schizoid personality disorder subjects, and nine anxiety/histrionic disorder patients were tested on a two-button task which required turning 180 degrees to collect coin reinforcers. Schizophrenic patients turned consistently left (16 times) significantly more (nine of 34) than normal controls, all of whom turned consistently right (chi 2 = 10.37, P = 0.005). Schizophrenic patients also turned left significantly more than the 18 affective disorder subjects, all of whom turned consistently right (chi 2 = 5.76, P = 0.02). All schizoid personality disorder subjects turned consistently right, and eight of nine anxiety histrionic disorder subjects turned consistently right. Left turning was not correlated with any other variables measured, including handedness, demographic, diagnostic and symptom variables. Left rotation has been previously measured during free ambulation in acute, non-medicated patients (Bracha, Biol. Psychiatry 22 (1987), 995-1003). Left turning bias in a subset of medicated, chronic schizophrenic inpatients may be linked to an underlying asymmetric striatal dopaminergic activity, specifically, an ipsilateral hypoactivity or contralateral hyperactivity, which would lead to left turning and right hemi-spatial neglect.

Adult↗

PubMedDate not supplied

Neuropsychological functioning in sons of active alcoholic, recovering alcoholic, and social drinking fathers.

Sons of active alcoholic, recovering alcoholic, and social drinking fathers were administered neuropsychological tests to assess whether they differ in their cognitive functioning. Multivariate analyses of variance showed that sons of active alcoholic sons perform significantly worse on visuospatial, memory, and attentional tasks as well as general intellectual functioning than sons of social drinking fathers. The sons of recovering alcoholic fathers showed no significant difference from social drinking fathers in their cognitive functioning. These results suggest that the clinical type of the alcoholic father (i.e., inability to abstain, more severe alcoholic vs. ability to abstain, less severe alcoholic) may be an important factor that determines whether offspring of alcoholics have neuropsychological deficits.

Adolescent↗

PubMedDate not supplied

Predictive validity of an abbreviated screening battery.

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Child, Preschool↗

PubMedDate not supplied

A methodological commentary on the Egyptian study of chronic hashish use.

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Age Factors↗

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Dynamic assessment of cognitive and cardiovascular performance in the elderly.

Dynamic measures of cardiovascular and cognitive performance have been used as a preliminary step toward developing predictors of decline in functional performance in older persons. Both batteries use multiple measures to examine the cooperativity of various aspects of performance, and both examine the subject's response to naturally occurring stresses. In these two senses, the measures are dynamic. For the cardiovascular measure we conducted ambulatory monitoring of blood pressure and pulse at 7.5-min intervals over a 24-h period. These parameters were analyzed simultaneously to examine changes in one relative to the others, using spectroscopy. After appropriate filtering, several dominant ultradian rhythms were noted, with periods of 47 min, 180 min and 6 to 8 h, the latter rhythm being present only in subjects aged greater than or equal to 60. A battery of computer-administered cognitive tests was developed to assess reaction time, visual recognition memory and word recognition memory. This testing allows for both a time and performance level grading. The results of the computer battery correspond well with those for standard neuropsychological tests. In general, performance declined with age, and reaction time increased. The computerized tests are faster, more consistently administered, and do not rely on a skilled professional for administration or analysis. They also provide a wide variety of measures that can be used in isolating components of performance. Once the acceptability and tolerance of older subjects toward such testing was established, attention shifted to questions of measurement stability and discriminant validity. Since the project's primary purpose is to predict subtle measures of decline in function, the battery's ultimate test is in its ability to correctly identify those about to change functional status. However, many different measures of status change are possible, and the predictive accuracy will depend on the outcome chosen. Subsequent work will focus on the predictors to refine measures and compare data collected at one point in time with the predictive power of change scores that reflect the individual subject's "signature." By-products of this work include a wealth of longitudinal physiologic and neuropsychologic data on older persons and tools that may be useful to the practicing physician.

Aged↗