Search PubMed⌕ Search

Biomedical subjects

P Sandstedt

Publications and source records attributed to P Sandstedt.

At least 19 recordsLinked to original sources
PubMed1997

Relationship between apical and marginal healing in periradicular surgery.

OBJECTIVE: The purpose of the present study was to evaluate the relationship between apical and marginal periodontal healing after periapical surgery. STUDY DESIGN: The investigation was conducted on 59 patients referred for periradicular surgery. A radiographic examination as well as assessments of periodontal attachment and pocket depth of teeth undergoing surgery and control teeth were performed at the time of surgery and 1 year after surgery. The radiographic periapical healing pattern was evaluated. RESULTS: After an observation time of 1 year, 85% of the healing patterns were classified as successful or uncertain. Teeth within the surgical area showed a significant loss of clinical attachment during the observation period. The mean clinical attachment loss in teeth with an unsuccessful healing was 0.85 mm and differed significantly from successfully healed cases (mean, 0.15 mm). CONCLUSIONS: A persisting endodontic infection may be regarded as a contributing risk factor for a progressing marginal attachment loss.

Adult↗
PubMed1996

[Good prognosis for very low birth weight infants].

A population-based multicentre study, comprising all very low birthweight (VLBW; < or = 1,500 g) infants born alive in the south-east region of Sweden during a 15-month period, was performed in the late 1980s. Among the VLBW infants there were 107 lifebirths (a rate of 0.72%), 86 (80.4%) neonatal survivors and no late deaths. Twenty (18.4%) had intracranial complications, two (2.3%) retinopathy of prematurity, grade 3, and six (5.6%) bronchopulmonary dysplasia. At follow-up at 18 months of uncorrected age, the VLBW infants were still lighter in weight and of shorter stature than control group infants. Of the five (5.8%) of the surviving VLBW infants who had significant neurological disorder at 18 months of age, all had weighed less than 800 g at birth, and had manifested neurological symptoms at 6 months of age. The hospitalisation rate during the first 18 months of life was greater in the VLBW than the control group.

Child Development↗
PubMed1995

Neurosensory disturbances of the trigeminal nerve: a long-term follow-up of traumatic injuries.

PURPOSE: This study assesses the physical and psychosocial consequences of trigeminal nerve damage. MATERIAL AND METHODS: A questionnaire consisting of 33 questions, 30 of which had fixed alternatives, was mailed to 300 persons who had received compensation from a syndicate of several insurance companies (Konsortiet för Patientförsäkring) because of trigeminal nerve damage. One question with no alternative reply gave the respondents an opportunity to comment on their problems and to rate them on a visual analogue scale. The questionnaire was answered by 226 recipients, 72 men and 153 women. RESULTS: Most of the patients had sensory disturbances resulting from damage to the inferior alveolar nerve, the mental nerve, or the lingual nerve. More than 70% of the respondents complained about paresthesia. No fewer than one of five patients suffered from pain in the affected area. The altered sensation caused functional disturbances in speech and eating which, in turn, had social and psychological consequences. CONCLUSIONS: This study shows that mainly women and older persons have the most severe discomfort after oral nerve damage.

Adolescent↗
PubMed1995

Replacing carbamazepine slow-release tablets with carbamazepine suppositories: a pharmacokinetic and clinical study in children with epilepsy.

A suppository for rectal administration of carbamazepine has been developed for situations in which it is unsuitable to use the oral route of administration. In an open, controlled, within-patient study, the pharmacokinetics, clinical efficacy, and tolerability of carbamazepine slow-release tablets were compared with those of carbamazepine suppositories in children with epilepsy. The pharmacokinetic part of the study comprised 22 children, and an additional nine children were included in the clinical part of the study. Treatment with slow-release tablets was replaced for 7 days with carbamazepine suppositories in bioequivalent dosage. Clinical factors such as the rate of seizures and the local tolerability were studied, and an overall assessment of efficacy was made. In the pharmacokinetic part, 24-hour plasma concentration curves for carbamazepine and carbamazepine-10,11-epoxide were recorded. The plasma concentration profiles (minimum, maximum, and mean concentrations, fluctuation index, and area under the curve) for carbamazepine and the other metabolites did not show any significant differences between oral and rectal administration when the suppository dose was increased by 25% compared to the tablets. No increase in seizure frequency was detected, and the overall assessment was very good to good in 25 of the 29 epileptic children. Increased flatulence during treatment with suppositories was noted in two children, one had anal irritation, and one had nausea/vomiting. Treatment with carbamazepine slow-release tablets in children with epilepsy can be replaced by carbamazepine suppositories in 25% higher dosage, with good clinical effect and appropriate pharmacokinetic values, when it is unsuitable to use the common oral route of administration.

Adolescent↗
PubMed1994

Withdrawal of antiepileptic medication in children. Correlation of cognitive function and plasma concentration--the multicentre 'Holmfrid' study.

Eighty-three patients with epilepsy and 83 matched controls completed 12 computerized cognitive tests while on antiepileptic drugs and six months later when they had been medication-free for three to four months. All patients had been seizure-free for more than one year and were on monotherapy with carbamazepine (CBZ, n = 56), valproate (VPA, n = 17), or phenytoin (PHT, n = 10). The tests and plasma concentration collection were done at noon. The mean peak plasma concentrations in the CBZ patients were as follows: 31% below 30 mumol/l, 48% between 30 and 42 mumol/l and 21% above 42 mumol/l. No difference in performance could be detected between the groups. One significant correlation between plasma concentration and test results was found. The mean VPA concentration was 625 mumol/l (S.D. 189). A tendency towards a weak negative correlation between test results and plasma concentration was present. The PHT patients' therapeutic range had a mean concentration of 32.0 mumol/l (S.D. 18.5). One significant correlation between a memory test and plasma concentration could be detected. Overall, the patients in the different antiepileptic groups performed less good than the control group and in a few cases the differences were statistically significant when compared either before or after withdrawal. A comparison of the changes after withdrawal showed improvement in the majority of tests, but these changes were also present in the matched control group.

Adolescent↗
PubMed1993

Withdrawal of antiepileptic medication in children--effects on cognitive function: The Multicenter Holmfrid Study.

We present 100 children diagnosed with epilepsy who were seizure-free for more than 1 year and still on monotherapy of antiepileptic drugs (AEDs). We matched each child with a healthy classmate and performed neuropsychological testing and EEG before and after complete withdrawal of the AEDs. The withdrawal phase lasted 3 months, but the dose decrease was individualized for each patient. Three to 4 months after complete withdrawal of the drug all patients were reassessed. Patients with seizure relapse are excluded from the study. Seventeen patients are regarded as dropout, 11 because of seizure relapse and six because of protocol violation. The remaining 83 patients were treated with carbamazepine (n = 56), valproic acid (n = 17), or phenytoin (n = 10). Serum concentrations of the AEDs were measured using peak plasma levels that were taken immediately before or after psychological testing. We used neuropsychological tests to assess psychomotor function and "central" cognitive processing such as information processing or memory function. We found significant improvement attributable to drug withdrawal on only one of the cognitive tests, namely, psychomotor speed, suggesting that the impact of AED treatment on higher-order cognitive function is rather limited. In addition, we found group differences between the epilepsy group and the control group at baseline that persisted after drug withdrawal. Subsequent analysis showed some factors that may have contributed to these group differences. First, patients with a former diagnosis of absence seizures show lower scores both at baseline and after drug withdrawal. We may assume that the seizure propensity has not disappeared completely in these patients. Some evidence is found that phenytoin may have a different cognitive profile than carbamazepine, with more impairment on tests that measure motor and mental speed. Again, this impairment persists after drug withdrawal.

Adolescent↗
PubMed1991

The importance of leg support for relaxation of the pelvic floor muscles. A surface electromyograph study in healthy girls.

The ability of relaxation is a necessary component for a good function of the pelvic floor muscles (PF). The importance of a relaxation technique for the PF has not been paid much attention in children either in urological examinations or treatments. The aim was to seek postures with optimal relaxation of the PF for use in clinical practice with girls. The relaxation of the PF and adjacent hip and abdominal muscle groups was studied by using surface electromyography (EMG) and a polygraph writer in 20 healthy volunteer girls, 6 and 10 years of age. They were placed in three different postures with their legs supported and unsupported. In postures with supported legs, the relaxation was observed in 94% recorded from the PF and in 97% from the adjacent muscles. EMG amplitudes from the PF and adductor muscles were significantly higher in postures with unsupported legs compared to postures with supported legs (p less than 0.05). The present study indicates that the optimal relaxation of the PF can be achieved by adequate leg support. This can be important to apply particularly in clinical situations such as urodynamic investigations, in uro-biofeedback training and for the design of pelvic floor exercises for girls.

Child↗
PubMed1990

Discontinuation of antiepileptic drugs in children who have outgrown epilepsy: effects on cognitive function.

Cognitive function is frequently impaired in children with epilepsy, compared with age-matched controls. It can be hard to evaluate the significance of various contributory factors. The effects of antiepileptic drugs may be studied in children who have outgrown their epilepsy but are still being treated. A multicenter study to assess various aspects of cognitive function in children with different forms of epilepsy, both during and after treatment with antiepileptic drugs, is currently under way. Definitive results are not yet available; interim analysis of the findings suggests that short-term memory is decreased in all subgroups of children being treated for epilepsy, compared to controls.

Adolescent↗
PubMed1989

Surface electromyography of pelvic floor muscles in healthy children. Methodological study.

Pelvic floor muscle activity was recorded in ten healthy children, aged six to ten years, by using surface electromyography and a polygraph writer. The electromyograms were recorded simultaneously from four electrode pairs on the perineum and three electrode pairs on adjacent muscle groups, i.e. hip and abdominis muscles. The children performed ten different manoeuvres. Necessary prerequisites for this investigatory method include good electrode application, adequate instruction of the child and the child's adjustment to the method. Using the described procedure, it was possible to record pelvic floor muscle activity without any appreciably detectable electrical influence from adjacent muscles. The method sometimes allows selective recording of electromyographic activity between the ventral urogenital and the dorsal anal regions. Therefore both anal and urethral electrode pairs should be used to achieve functional information about the pelvic floor muscles. The envisaged method should be useful as a tool for assessment of pelvic floor muscle exercises in children with voiding disorders.

Child↗
PubMed1989

Experiences of rocket seat ejections in the Swedish Air Force: 1967-1987.

From 1967 to 1987 there were 83 successful and 9 fatal ejections with Saab rocket seats in the Swedish Air Force. Medical consequences and injury factors are reviewed. Thirty-nine survivors had nontrivial injuries; four were seriously injured. The risk for injury has been approximately 50% throughout the period. Two-thirds of the survivors resumed flying within a week, the remainder after up to 1 year, except for three pilots who terminated their flying status.

Accidents, Aviation↗
PubMed1985

Peripheral facial palsy in children. A cerebrospinal fluid study.

Seven children and five adults with acute, peripheral facial palsy were investigated by clinical, blood and cerebrospinal fluid (CSF) examinations. Routine blood examinations and blood and CSF serological tests were normal. In all children studied the CSF showed an increased number of mononuclear white cells despite the absence of clinical signs of meningitis in all but one. Two of the twelve patients studied had normal CSF. Contrary to that in adults the outcome in children was excellent, all recovered totally within three months. The present study indicates that acute, peripheral facial palsy is a manifestation of a generalized disorder with subclinical pathology of the central nervous system, and that in children a lumbar puncture should be done, even if there are no signs of meningitis.

Adult↗
PubMed1984

Postural sway and gait of children with convergent strabismus.

Postural sway and gait of 35 children with convergent strabismus were tested and compared with those of a control group. They were found to have a short stride-length and single-limb support time in walking, particularly at slow speeds. The girls had a large postural sway, but not the boys. The results suggest a common visuomotor disturbance of eye and limb motor-control.

Child↗
PubMed1984

Development of postural sway in the normal child.

The postural sway was examined in 64 healthy children, aged 3.5 to 17 years. The recordings were done in ordinary standing posture on a force platform, with eyes open and closed. For children younger than 10 years, boys swayed more than girls. The sway amplitude decreased with age for boys, but not for girls. The decrease in sway was equally pronounced in sagittal and lateral direction. The amplitude of sway was higher in sagittal than in lateral direction.

Adolescent↗