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Biomedical subjects

P Salmon

Publications and source records attributed to P Salmon.

At least 73 records · Page 4Linked to original sources

Is patient-controlled analgesia controlled by the patient?

Using patient-controlled analgesia (PCA) after surgery, a patient can obtain pain-relieving injections of morphine without the direct involvement of a nurse or doctor. The present study was a response to the conventional view that patients value PCA because of the control which it affords them over their own treatment. Twenty-six patients underwent semi-structured interviews postoperatively, shortly after discontinuation of PCA. Responses were examined qualitatively to identify recurring themes in patients' experience of PCA. Negative as well as positive evaluation was found. PCA was only rarely described as a way of gaining control over analgesia and, in general, this was not valued. Instead, PCA was valued as a way to avoid the difficulty of disclosing pain or securing pain relief within the usual nurse-patient relationship. In turn, PCA strained the nurse-patient relationship where it impeded either the patient's or the nurse's wish for the nurse to take responsibility for pain relief. The results showed that the professionally and theoretically constructed concept of PCA as a method of self-control over pain is inconsistent with patients' experience of it.

Adult↗

Measuring the meaning of life for patients with incurable cancer: the life evaluation questionnaire (LEQ).

Clinical observation, systematic research and popular anecdote indicate that, when confronted by death, people change the criteria by which they evaluate their lives. Questionnaires used routinely to assess quality of life in people with poor-prognosis cancer tend to be symptom-based and do not assess factors which become important when confronted by fatal illness, such as the meaning of life and the degree to which life has been enriched by the illness. To develop a questionnaire which would be sensitive to these areas, patients with incurable cancer and carers of such patients were interviewed in depth. Responses were reviewed by a panel of patients, clinicians and carers and formed into an inventory which was completed by 200 similar patients. Principal components analysis identified five dimensions: clearer perception of the meaning of life; freedom versus restriction of life; resentment of the illness; contentment with past and present life; past and present social integration. Only the most symptom-oriented scales (freedom, resentment) correlated with the Rotterdam Symptom Checklist. Scale scores showed that younger patients were more resentful of their illness, but also gained a clearer perception of the meaning of life. This questionnaire can evaluate psychological needs of people with incurable cancer which are neglected by existing instruments.

Age Factors↗

Pharmacokinetics and pharmacodynamics of recombinant human interferon-beta in healthy male volunteers.

The pharmacokinetics and pharmacodynamics of recombinant human interferon-beta (rHuIFN-beta 1a) were assessed following administration to 12 healthy male volunteers. Each subject received, in a double-blind, balanced, random-order, crossover sequence, single doses of 6 MIU of rHuIFN-beta 1a (Rebif) i.v., i.m., and s.c. or matching placebo on four occasions separated by washout periods of 1 week. Blood samples were collected at preset times for the measurement of serum IFN-beta levels and of intracellular 2'-5'-oligoadenylate synthetase levels. Blood pressure, sitting heart rate, respiratory rate, oral body temperature, and tolerance were monitored regularly. All administrations of rHuIFN-beta 1a were well tolerated, although about half of the subjects had a flu-like syndrome, as expected. After i.v. bolus injection, the pharmacokinetics of rHuIFN-beta 1a were well described by a classic two-compartment model. Mean total clearance of rHuIFN-beta 1a was about 100 L.h-1. The distribution half-life was 5 min, and the terminal half-life was approximately 5 h. After i.m. or s.c. injection, serum IFN-beta profiles were rather flat, and about one sixth of the administered dose was available systemically. Extent and duration of clinical and biologic effects were independent of the route of administration and of the IFN-beta serum levels. Biologic pharmacodynamic effects persisted even when IFN-beta serum levels had returned to baseline and were still significantly elevated 3 days after a single dose. Because of the independence of the extent and duration of clinical and biologic pharmacodynamic effects from the route of administration and from the IFN-beta serum levels, the s.c route of administration is preferred in indications in which primarily an immunomodulatory action is sought. Predominantly antiviral and antiproliferative activity is enhanced by the i.v. route to provide adequate drug levels at the site of pathology, although its application is limited on practical grounds.

2',5'-Oligoadenylate Synthetase↗

Patients' experiences of patient-controlled analgesia.

We examined patients' experiences of patient-controlled analgesia by the use of semistructured interviews in 26 patients shortly after discontinuation of the device. The options expressed by the patients were examined qualitatively to identify recurring themes in their experience of patient-controlled analgesia. The areas of interest were analgesia, factors influencing whether the patient pressed the button or not, whether they felt in control and side effects. Negative as well as the expected positive evaluations were found. The negative evaluations reflected problems with nausea and vomiting and inadequate analgesia. No clear strategy for pressing, or not pressing, the button emerged and the principle of control by the patient over their pain relief was not considered important.

Adult↗

Truncated mammalian Notch1 activates CBF1/RBPJk-repressed genes by a mechanism resembling that of Epstein-Barr virus EBNA2.

The Notch/Lin-12/Glp-1 receptor family participates in cell-cell signaling events that influence cell fate decisions. Although several Notch homologs and receptor ligands have been identified, the nuclear events involved in this pathway remain incompletely understood. A truncated form of Notch, consisting only of the intracellular domain (NotchIC), localizes to the nucleus and functions as an activated receptor. Using both an in vitro binding assay and a cotransfection assay based on the two-hybrid principle, we show that mammalian NotchIC interacts with the transcriptional repressor CBF1, which is the human homolog of Drosophila Suppressor of Hairless. Cotransfection assays using segments of mouse NotchIC and CBF1 demonstrated that the N-terminal 114-amino-acid region of mouse NotchIC contains the CBF1 interactive domain and that the cdc10/ankyrin repeats are not essential for this interaction. This result was confirmed in immunoprecipation assays in which the N-terminal 114-amino-acid segment of NotchIC, but not the ankyrin repeat region, coprecipitated with CBF1. Mouse NotchIC itself is targeted to the transcriptional repression domain (aa179 to 361) of CBF1. Furthermore, transfection assays in which mouse NotchIC was targeted through Gal4-CBF1 or through endogenous cellular CBF1 indicated that NotchIC transactivates gene expression via CBF1 tethering to DNA. Transactivation by NotchIC occurs partially through abolition of CBF1-mediated repession. This same mechanism is used by Epstein-Barr virus EBNA2. Thus, mimicry of Notch signal transduction is involved in Epstein-Barr virus-driven immortalization.

Amino Acid Sequence↗

Short-term recovery from hip and knee arthroplasty.

There are many studies of long-term recovery from major point arthroplasty, but little is known about the first days and weeks after operation. We measured function, emotional state and life evaluation before arthroplasty and at seven and 50 days after in a consecutive series of 40 hip and 23 knee replacements. Pain was relieved significantly at seven days after hip arthroplasty and even more at 50 days. In knee patients, pain relief was modest and was not apparent until 50 days. Functional ability was much improved by 50 days in hip patients, but hardly changed in knee patients. Positive mood and life satisfaction did not improve in either group. Our findings will help with more accurate information for patients before operation and also in judging the rate of recovery.

Aged↗

Taking the problem oriented medical record forward.

The problem oriented medical record (POMR) has proved to be very successful in providing a structure that helps doctors record their notes about patients, and view those notes subsequently in a manner that quickly gives them a good understanding of that patients history. This approach has been validated by the American Institute of Medicine. With the increased use of computer systems that implement the POMR by doctors, the limitations of this structure have become apparent, and there is clearly scope for developing the model further to improve the quality of the data recorded, and adding meaning to it. This paper describes some of the limitations of the POMR, and discusses a number of areas in which it may be extended. Crucially, this is done in a manner which is both implementable, and usable. The extensions explored include some types of entity including encounters, episodes and subproblems; and an alternative view-the Timeline. The terminology used for the extensions is clarified. Mechanisms by which these extensions have been implemented are described. Ways in which systems can manage these extensions automatically are suggested. Such implementations are constrained by the need not to allow the demands of the computer to intrude into the patient encounter. They are also constrained by the requirements for reporting by professional and governmental institutions, and by what is pragmatically feasible in software and hardware.

Computer Systems↗

Stress responsivity in exercisers and non-exercisers during different phases of the menstrual cycle.

It has been suggested that, premenstrually, women are more vulnerable to the effects of stress. It has also been proposed that the fitter the individual is, the less the body responds to, and the more quickly it recovers from, a stressful experience. The present study investigated whether premenstrual sensitivity to a stressful laboratory task would be attenuated in women who exercised. Responses to the task across the menstrual cycle were studied in 20 women who exercised regularly and 20 women who were sedentary. Heart rate and blood pressure as well as subjective mood responses were measured in each of three phases: premenstrual, menstrual and postmenstrual. Exercising and sedentary women differed in sensitivity to stress: heart rate responsivity to stress was less in exercisers, but mood fluctuation was greater. Menstrual cycle phase, by contrast, influenced general levels of heart-rate and mood, but did not affect responsivity to stress or performance. These findings suggest that the menstrual cycle and physical exercise have independent effects on cardiovascular and emotional state.

Adaptation, Psychological↗

How do women cope with menstrual cycle changes?

Very little is known about how women naturally cope with premenstrual and menstrual symptoms. A sample of 342 women was therefore surveyed to discover how they coped with menstrual cycle changes and how helpful these methods were. Principal components analysis of responses to a specially devised coping checklist revealed four components which corresponded to types of coping distinguished in the literature. These were termed: active-behavioural, active-cognitive, avoidance and menstrual cycle specific. There was no relationship between the extent to which particular coping strategies were used and how helpful they were thought to be. The most popular ways of coping were active-cognitive. The most helpful were active-behavioural and active-cognitive. Further analyses did not show any effect of parity or occupational group on the frequency or helpfulness of the different types of coping; nor was there any association with age. Modest correlations of coping methods with symptom severity emerged.

Adaptation, Psychological↗

Symptom changes across the menstrual cycle in competitive sportswomen, exercisers and sedentary women.

Anecdotal accounts and unsystematic reports have suggested that women who exercise experience fewer premenstrual symptoms and less severe dysmenorrhoea than women who are sedentary. The present study tested this belief. Mood states and physical symptoms of 143 women were monitored for five days in each of the three phases of the cycle (mid-cycle, premenstrual and menstrual). The women were 35 competitive sportswomen, two groups of exercisers (33 high exercisers and 36 low exercisers) and 39 sedentary women. Principal component analysis of their responses to a mood and physical symptom checklist revealed five dimensions: positive affect, negative affect, physical symptoms, fatigue and irritability. Component-based subscale scores were calculated for all dimensions. In general mood and symptoms were worse menstrually and premenstrually than mid-cycle. The high exercisers experienced the greater positive affect and sedentary women the least. The high exercisers also reported the least negative affect. The differences between exercise groups were greatest during the premenstrual and menstrual phases. These results are consistent with the belief that women who frequently exercise may be to some extent protected from deterioration of mood before and during menstruation. This, however, is not the case for competitive sportswomen.

Adult↗

Patients' influence on doctors' behavior: a case study of patient strategies in somatization.

OBJECTIVE: Extensive empirical data and theory describe the inequality of power in relations between doctors and their patients. However, the focus has been on the ways in which doctors control the doctor-patient relationship. This has meant that the extent to which patients influence the consultation, and the ways in which they do this, have been neglected. METHODS: In this article, we use a single case to identify and illustrate distinct ways in which patients exert power to determine the outcome of consultations. CONCLUSION: This analysis leads to a more powerful explanation than is presently available to understand the somatization of psychological needs. According to this, the patient organizes strategies, which include the presentation of emotional and social distress, around a biomedical model. Because of their prior decisions as to their role, doctors permit themselves to be trapped in this model.

Communication↗

Post-operative fatigue following coronary artery bypass surgery: relationship to emotional state and to the catecholamine response to surgery.

Post-operative fatigue is an important subjective problem for surgical patients, but its basis is unknown, and the possibility of a psychological component has been neglected. To investigate its putative physiological and psychological bases, 74 patients undergoing coronary artery bypass graft surgery were studied. Circulating catecholamine levels were measured at intervals perioperatively and questionnaires were used to measure fatigue, depression and anxiety up to 30 days post-operatively. We tested whether fatigue was related either to the catecholamine or to the emotional responses to surgery. The second element to the design was a controlled randomized study: patients underwent different forms of psychological preparation or a no-treatment control procedure in an attempt to test whether post-operative fatigue was amenable to psychological manipulation. Psychological preparation had no effect. Fatigue at 30 days was greatest in patients whose noradrenaline levels were greatest perioperatively. Independently of this relationship, fatigue at 30 days correlated with concurrent levels of depression and anxiety. Post-operative fatigue has both physiological and psychological correlates.

Adaptation, Psychological↗

Patients' intentions in primary care: relationship to physical and psychological symptoms, and their perception by general practitioners.

A series of three studies of consecutive primary care patients examined their intentions when visiting a general practitioner (GP). In study 1, a principal, components analysis of responses to a specially-devised symptom check-list was used to form component-based scales on which patients' physical symptoms were scored. Apart from a modest association of cold symptoms with seeking simple explanation, physical symptoms were unrelated to intentions. By contrast, the level of psychological symptoms correlated with the desire for support from the GP. In study 2 this result was replicated and shown to be unaffected by the amount of support which patients already experienced from family and friends. In study 3, GPs were found to be able to detect at better than chance level which patients desired support, but they were insensitive to other intentions. The results indicate that a technique for the quantification of patients' intentions permits the formal investigation of important questions concerning primary care consultations.

Female↗

Evaluating customer satisfaction with colonoscopy.

Twenty patients were interviewed shortly after colonoscopy, and the adjectives and phrases they used to describe the experience were formed into a 31-item questionnaire, on which each item was rated using a seven-point scale. This questionnaire was completed by 110 similar patients. Principal components analysis of these responses yielded three components: satisfaction, physical discomfort, and emotional distress. This demonstrates that patients' experience of colonoscopy is multi-dimensional; whether or not a patient feels satisfied is unrelated to how distressing or uncomfortable it is. Component-based scale scores were calculated so as to quantify every patient's experience on each dimension. Procedures performed by the most experienced endoscopist were no less uncomfortable than others, but they were less distressing. Female patients experienced more discomfort than males, but were no more distressed or less satisfied. This questionnaire could be useful in any future audit of colonoscopy from the patients' point of view.

Analysis of Variance↗

Qualitative and quantitative effects of running on mood.

This study examines the assumption that the dimensional structure of mood following strenuous physical exercise is unchanged by comparison with that beforehand. A specially-devised adjective checklist was completed by 165 regular runners 5-10 minutes before, and immediately after, a 3-mile run. Principal components analyses of the scores revealed independent dimensions of positive and negative affect which were similar on both occasions. There was no evidence of a separate major dimension of elation or well-being after running. The structure of mood differed before and after running only in minor components. Component-based scale scores were calculated for each subject, for each occasion. Positive mood was increased, and negative mood decreased, after running. The main changes in mood caused by running in these conditions are therefore quantitative rather than qualitative. Improvements in mood were greater in women than in men, largely because women experienced a worse mood state than did men before running.

Adult↗