Biomedical subjects
Publications and source records attributed to P S Shankar.
The paper describes two individuals presenting with acute insulin dependent diabetes mellitus for a brief and transient period. Both had had chicken pox infection in the immediate past. After establishing good diabetic control, insulin was withdrawn over a few weeks. Follow-up for the next two years did not reveal recurrence of diabetes. A causal relation between varicella zoster virus and the onset of diabetes is suggested.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
In the case of Legionnaires' disease described, severe respiratory problems necessitated mechanical ventilatory support, tracheal intubation, and positive end-expiratory pressure. Fever was eliminated with erythromycin therapy but returned after five days, and lung infiltrates spread. After supplementary treatment with other antibiotics and methylprednisolone sodium succinate, both the fever and the infiltrates disappeared. We feel that the multisystem involvement and the recrudescence of fever in our patient emphasize the wide spectrum of characteristics of Legionnaires' disease and the importance of continuation of antibiotics for a prolonged period to eradicate infection.
Primary carcinoma of the lung may accompany or follow primary carcinoma of the larynx. This relationship was noted in 2 patients in whom the tumors occurred synchronously, and in 3 in whom they occurred metachronously. The lung cancer with bronchopulmonary symptoms in the synchronous group, and with an abnormal radiographic shadow (1 to 5 years after treatment for laryngeal carcinoma) in the metachronous group. The lung growth (squamous-cell carcinoma) was confined to the upper lobes. The patients were all heavy cigarette smokers. The epithelium of the entire respiratory tract seems susceptible to malignant change. Patients who have undergone treatment for laryngeal carcinoma should be followed by periodic radiologic examination, as they are at greater risk for the development of a new malignant lesion in the lung. Moreover, patients with bronchogenic carcinoma require routine laryngoscopic examination to discover or rule out any coexistent primary growth in the larynx.
Synchronous dual primary lung carcinomas were found in 8 of 482 patients with lung cancer, an incidence of 1.6 percent. Of the 8 cases, 7 were unilateral and one bilateral. Three showed dissimilar histologic patterns occurring in combinations of squamous-cell carcinoma and adenocarcinoma. In 5 cases, two separate tumors were noted with identical histologic patterns in combinations of squamous-cell, giant-cell, large-cell, adeno-. and undifferentiated carcinoma. The patients were heavy smokers and this possibly may have been a factor in the development of carcinoma at more than one site.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.