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Biomedical subjects

P S Myers

Publications and source records attributed to P S Myers.

10 recordsLinked to original sources
PubMed1999

Process-oriented treatment of right hemisphere communication disorders.

Lacking knowledge about the cognitive processes that underlie communication impairments in patients with right hemisphere damage (RHD) and driven by increasingly limited treatment duration, speech-language pathologists often give little thought to process-oriented treatment. However, operating from a theoretical perspective in which treatment targets the processes that underlie symptoms can result in more effective treatment of a range of symptoms due to a common processing impairment. This article provides research-driven therapeutic approaches based on sound theoretical perspectives that can be combined with task-specific therapy to maximize therapeutic outcomes with this clinical population.

Brain Diseases↗
PubMed1998

Interactions in the TonB-dependent energy transduction complex: ExbB and ExbD form homomultimers.

The cytoplasmic membrane proteins ExbB and ExbD support TonB-dependent active transport of iron siderophores and vitamin B12 across the essentially unenergized outer membrane of Escherichia coli. In this study, in vivo formaldehyde cross-linking analysis was used to investigate the interactions of T7 epitope-tagged ExbB or ExbD proteins. ExbB and ExbD each formed two unique cross-linked complexes which were not dependent on the presence of TonB, the outer membrane receptor protein FepA, or the other Exb protein. Cross-linking analysis of ExbB- and ExbD-derived size variants demonstrated instead that these ExbB and ExbD complexes were homodimers and homotrimers and suggested that ExbB also interacted with an unidentified protein(s). Cross-linking analysis of epitope-tagged ExbB and ExbD proteins with TonB antisera afforded detection of a previously unrecognized TonB-ExbD cross-linked complex and confirmed the composition of the TonB-ExbB cross-linked complex. The implications of these findings for the mechanism of TonB-dependent energy transduction are discussed.

Bacterial Outer Membrane Proteins↗
PubMed1996

Effect of visual and inferential variables on scene descriptions by right-hemisphere-damaged and non-brain-damaged adults.

This study investigated the effects of visual and inferential complexity on the pictured scene descriptions of right-hemisphere-damaged (RHD) and non-brain-damaged (NBD) adults. The number and accuracy of noun phrases generated by both groups were significantly affected by the inferential complexity of pictured scenes, but not by their visual complexity (as measured by the number of objects and amount of object embedding in the scenes). RHD subjects, particularly those with high levels of neglect, were significantly impaired relative to the NBD subjects in generating accurate inferences from the pictures, but not in their ability to recognize and identify pictured elements.

Adult↗
PubMed1996

Identification of TonB homologs in the family Enterobacteriaceae and evidence for conservation of TonB-dependent energy transduction complexes.

The transport of Fe(III)-siderophore complexes and vitamin B12 across the outer membrane of Escherichia coli requires the TonB-dependent energy transduction system. A set of murine monoclonal antibodies (MAbs) was generated against an E. coli TrpC-TonB fusion protein to facilitate structure and function studies. In the present study, the epitopes recognized by these MAbs were mapped, and their distribution in gram-negative organisms was examined. Cross-species reactivity patterns obtained against TonB homologs of known sequence were used to refine epitope mapping, with some epitopes ultimately confirmed by inhibition experiments using synthetic polypeptides. Epitopes recognized by this set of MAbs were conserved in TonB homologs for 9 of 12 species in the family Enterobacteriaceae (including E. coli), including previously unidentified TonB homologs in Shigella, Citrobacter, Proteus, and Kluyvera species. These homologs were also detected by a polyclonal alpha-TrpC-TonB serum that additionally recognized the known Yersinia enterocolitica TonB homolog and a putative TonB homolog in Edwardsiella tarda. These antibody preparations failed to detect the known TonB homologs of either Pseudomonas putida or Haemophilus influenzae but did identify potential TonB homologs in several other nonenteric gram-negative species. In vivo chemical cross-linking experiments demonstrated that in addition to TonB, auxiliary components of the TonB-dependent energy transduction system are broadly conserved in members of the family Enterobacteriaceae, suggesting that the TonB system represents a common system for high-affinity active transport across the gram-negative outer membrane.

Amino Acid Sequence↗
PubMed1988

Medical care costs of patients with acquired immunodeficiency syndrome in Richmond, Va. A quantitative analysis.

This study examines inpatient charges for 52 adult patients with the acquired immunodeficiency syndrome (AIDS) who had 102 admissions to the Medical College of Virginia Hospitals, Richmond, from October 1983 through December 1986. Complete charge data were available for 81 hospitalizations; the mean charge per hospitalization was +13,830 (SD, +13,610), the average length of stay was 14.8 days (SD, 13.1 days), and the mean per diem charge was +1058 (SD, +802). For patients who received all their AIDS-related medical care at the Medical College of Virginia Hospitals, total lifetime hospital charges averaged +27,264, the mean number of hospital stays was 2.29, and the average length of stay was 12 days. The average length of hospital stay, total charges per hospitalization, and average charge per day of hospitalization decreased over the study period. These findings suggest that inpatient costs of treating individual patients with AIDS are less than initially estimated and are decreasing due to the ability to more effectively manage these patients.

Acquired Immunodeficiency Syndrome↗
PubMed1987

Pooling the AIDS risk.

Explore the source record for details and available documents.

Acquired Immunodeficiency Syndrome↗
PubMed1980

Localization of a mosquito-larval toxin of Bacillus sphaericus 1593.

Cell-free wall, membrane, and cytoplasmic fractions were prepared from Bacillus sphaericus 1593, which exhibited toxic activity against larvae of the mosquito Culex pipiens var. quinquefasciatus. Breakage of 12- to 14-h cells by sonication or French pressure cell yielded toxic material which could be assayed in a standard mosquito larva bioassay. When sporulating cells of strain 1593 were fractionated, the majority of the toxic activity was localized in the cell wall rather than in the plasma membrane or cytoplasm. The toxin located in the bacterial cell wall was relatively stable, in that activity was unaffected by treatment with trypsin, pronase, CHCl3-CH3OH-water, Triton X-100, 8 M urea (30 min), heat (80 degrees C, 12 min), sonication, refrigeration, lyophilization, or freezing. Activity was destroyed by boiling for 10 min or by 0.01 N NaOH. Only about 1.0% of the activity present in purified cell walls could be recovered by a 2-h extraction with 8 M urea or 3 M guanidine hydrochloride. A comparison of the toxicity of a cell-free cell wall fraction with that of a sample consisting entirely of heat-stable spores indicated that the spore preparation was about 10 times more active.

Animals↗
PubMed1975

Nonautotrophic Thiobacillus in acid mine water.

Nonautotrophic thiobacilli were isolated from the acidic water of a coal mine. Based on their mixotrophic physiology, the isolates are regarded as strains of Thiobacillus perometabolis.

Carbohydrate Metabolism↗