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Biomedical subjects

P S Murthy

Publications and source records attributed to P S Murthy.

At least 55 records · Page 3Linked to original sources
PubMed1991

Otogenic brain abscess in childhood.

Brain abscesses are quite rare complications of middle ear infections. Although temporal lobe abscesses are more common than cerebellar abscesses, the converse was found to be true in our series of 10 cases. Eight cases of cerebellar abscess and 2 cases of temporal lobe abscess in the paediatric age group were reported including 4 cases of latent brain abscesses which manifested themselves after mastoidectomy for middle ear infection. Brain abscess is by far the most serious of otogenic complications.

Adolescent↗
PubMed1990

Elongated styloid process: an overview.

Stylalgia is a condition that causes a dull, nagging pain in the oropharynx, often referred to the ear and the mastoid region. The clinical diagnosis is certain if the elongated styloid process is palpated through the tonsillar area. Radiological investigations, such as orthopantomograms, give information about the medial angulation. The treatment of choice is surgical shortening of the process. Trans-tonsillar fossa excision is a simple technique and does not involve greater morbidity than a routine tonsillectomy.

Adult↗
PubMed1989

Role of plasminogen activators and leukocytes in IUD-induced inflammation: effect of some anti-inflammatory agents.

Insertion of an IUD causes a persistent inflammatory reaction, evident from an increase in the vascular dilatation and permeability of IUD-exposed endometrium. IUD-induced inflammatory changes can be checked by using anti-inflammatory drugs. In this study in rats, we report that IUD-induced inflammatory changes were partially checked by the use of anti-inflammatory drugs, in order of effectiveness, indomethacin greater than naproxen greater than ibuprofen. Histologically, IUDs provoke mild degeneration of uterine epithelium and necrotic changes in the endometrial glands. Heavy infiltration of polymorphonuclear leukocytes (PMNs) in the uterine lumen was also noticed. IUD-induced degenerative changes in the histoarchitecture of uterine epithelium were partially repaired following treatment with anti-inflammatory drugs.

Animals↗
PubMed1989

Effect of herbicide banvel on rabbit vaginal mucus membrane.

Effect of banvel and its active ingredient, dicamba (3,6-dichloro-o-anisic acid) was investigated employing rabbit mucus membrane irritancy test. Inflammatory changes which did not exceed an average score of 2+ were observed in the animals 48 hr after a single intravaginal application of banvel (0.1 ml/rabbit) and dicamba (100 mg/rabbit). Persistent histopathological changes were observed in 1 out of 6 banvel-treated rabbits 15 days post-application. The results suggest that banvel and dicamba are not primary irritants but should nevertheless be employed with caution.

Animals↗
PubMed1983

An acute infection model for Mycobacterium intracellulare disease using beige mice: preliminary results.

The development of an acute infection model of Mycobacterium intracellulare disease in Beige mice (C57B1/6J-bgJ/bgJ) was investigated. Intravenous injection of 1 x 10(7) viable colony-forming units of M. intracellulare strain 571-8 produced a 1,000-fold increase in the number of mycobacteria recovered from the lungs and spleens after 28 days of infection. More importantly, 40% of the beige mice died from this infection, as was determined from histopathologic sections and bacterial culturing.

Animals↗
PubMed1976

Studies on cardiolipin biosynthesis in Mycobacterium smegmatis.

Supplementation of a growth medium with 5% glucose has been found to stimulate the formation of cardiolipin and phosphatidylethanolamine five- and threefold, respectively, in Mycobacterium smegmatis. The presence of both cytidine diphosphate diglyceride and phosphatidylglycerol pathways of biosynthesis of cardiolipin in cell-free extracts has been demonstrated. The enzymes were localized in the fractions which contained membranes. Isonicotinic acid hydrazide and streptomycin sulfate inhibited the formation of cardiolipin.

Cardiolipins↗