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Biomedical subjects

P S London

Publications and source records attributed to P S London.

At least 19 recordsLinked to original sources
PubMed1993

Fracture-dislocations of the spine that may spare the cord: an explanation.

The combination of severe fracture-dislocation of the spine with little or no damage to the spinal cord and its roots is rare. There is a characteristic pattern of bony injury that seems most likely to result from a combination of extension and longitudinal compression and may not endanger the neural tissue. The usual clinical features of severe injury of the spine may be lacking and the radiological interpretation is difficult. Although the reports suggest that these injuries are stable in deformity this may not always be so and the spine should be afforded the usual protection.

Accidents, Aviation↗
PubMed1981

The somatomedin activity in plasma from patients with multiple mechanical injuries: with observations on plasma cortisol.

The somatomedin activity (SMA) was assayed in 247 plasma samples from 30 patients with moderate or severe injuries. The injury severity score (ISS) was assessed for each patient and ranged from 9 to 50. The plasma SMA was reduced or eliminated within 4 days of injury. The activity then increased in the patients who recovered, normal levels being attained within 1 or 2 weeks of the injury. Five patients had at least one further fall in plasma SMA during treatment. Seven patients died and 4 of these had little or no SMA before death. The magnitude and duration of the depression of SMA after injury correlated both with the ISS and with the probability of mortality. The plasma cortisol concentration was elevated in all but 4 patients within 48 hours of injury. There was no relationship between the plasma SMA and the cortisol concentration. When plasma samples from 10 patients taken soon after injury were mixed with normal human serum, samples from only 1 patient were found to contain an inhibitor(s) of SMA. The reduced plasma SMAs in the remaining patients may have resulted from the impaired production of somatomedins (SM), the degradation of SM, the dilution of circulating SM with transfusion fluids or the binding of SM to damaged tissues.

Accidents↗