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Biomedical subjects

P S Hughes

Publications and source records attributed to P S Hughes.

8 recordsLinked to original sources
PubMed1998

Absence of human papillomavirus DNA in the plume of erbium:YAG laser-treated warts.

BACKGROUND: The erbium:YAG laser (Continuum Biomedical, Dublin, Calif.) is a new resurfacing and ablating laser that produces minimal residual thermal damage. Laser safety requires careful attention to the hazards of the laser plume. It is important to know whether viable organisms survive in the vapors. Human papillomavirus (HPV) DNA has been detected in the vapor of carbon dioxide laser-treated and electrodesiccated human warts. The presence or absence of HPV DNA in the laser plume of erbium:YAG laser-treated warts has not been previously studied to our knowledge. OBJECTIVE: Our purpose was to determine the presence or absence of HPV DNA in the laser plume of erbium:YAG laser-treated human warts. METHODS: One half of clinically typical and histopathologically confirmed verrucae vulgares from five patients were submitted for HPV DNA detection with in situ hybridization. After erbium:YAG laser ablation of the remainder of the warts, the laser plume was deposited on the handpiece as an abundant fluffy material and was submitted for evaluation of HPV DNA by polymerase chain reaction with consensus primers for the HPV type detected in the wart specimens. RESULTS: HPV2 DNA was found in all warts. HPV DNA was not detected in the erbium:YAG laser plume after ablation of these same warts. CONCLUSION: The absence of HPV DNA in the plume of erbium:YAG laser-treated warts is a significant safety feature of this laser.

DNA, Viral↗
PubMed1998

Skin contraction following erbium:YAG laser resurfacing.

BACKGROUND: Resurfacing the skin with deep chemical peels, dermabrasion, or lasers tightens the skin via dermal remodeling. The erbium (Er):YAG laser is a new laser for resurfacing and it removes lesional tissue efficiently with minimal residual thermal damage. In this paper, I present the first published study, to my knowledge, documenting and quantifying the cutaneous contraction following Er:YAG laser resurfacing of human skin. OBJECTIVE: To document and measure the cutaneous contraction resulting from Er:YAG laser resurfacing. METHODS: Using lentigos as skin markers, square areas on human forearm skin were resurfaced with the Er:YAG laser. The distance between these skin markers was measured before, immediately after, at 3 days, and weekly for 16 weeks after laser surgery. RESULTS: After two to three passes with the Er:YAG laser, there was an immediate 4% linear tightening of the skin, which persisted at 3 days, increased to 8% at 1 weeks, was 11% at 2 and 4 weeks, 13% at 6 weeks, and 14% at 16 weeks. CONCLUSION: Er:YAG laser resurfacing produces measurable cutaneous contraction. This phenomenon may contribute to the positive clinical tightening of human skin following Er:YAG laser resurfacing.

Dermatologic Surgical Procedures↗
PubMed1998

Treatment of molluscum contagiosum with the 585-nm pulsed dye laser.

BACKGROUND: Molluscum contagiosum nodules are common viral-induced lesions that are troublesome to treat, especially in children. I report the first study, to my knowledge, demonstrating effective, well-tolerated, and quick treatment of these lesions with the 585-nm pulsed dye laser. OBJECTIVE: To determine the effectiveness and ease of 585-nm pulsed dye laser treatment of molluscum contagiosum. METHODS: Eighty-eight lesions were treated by double-pulsing them at 1 Hz (one pulse per second) with a 3-mm spot size (fluence, 7.0-8.0 J/cm2) or 5-mm spot size (fluence, 6.8-7.2 J/cm2). RESULTS: Eighty-seven of the 88 lesions resolved completely with one treatment. CONCLUSION: The 585-nm pulsed dye laser is an effective, well-tolerated, and quick treatment for molluscum contagiosum.

Adolescent↗
PubMed1979

Cryosurgery of verrucous carcinoma of the penis (Buschke-Lowenstein tumor).

Verrucous carcinoma of the penis (Buschke-Lowenstein tumor, giant condyloma accuminatum) is a common clearly defined variant of epidermoid carcinoma which features relentless local growth and little tendency to metastasize. Two cases successfully treated by liquid nitrogen cryosurgery are presented herein.

Adult↗
PubMed1977

Acral syringoma.

Although syringoma is a relatively common adnexal tumor, syringoma of the hands has not been reported previously. We report a unique case of multiple acral syringomas that appeared as symmetrical grouped erythematous papules limited to the dorsum of the proximal and middle phalanges of both hands in a young man. This condition should be considered in the diagnosis of papular lesions of the hands.

Adenoma↗