Biomedical subjects

P Ruoppi

Publications and source records attributed to P Ruoppi.

22 records · Page 2Linked to original sources

PubMed1986

Long-term safety and efficacy of budesonide nasal aerosol in perennial rhinitis. A 12-month multicentre study.

A long-term safety study of intranasally administered budesonide, a topical glucocorticoid, has been performed. 104 patients with perennial rhinitis, allergic or non-allergic, participated in a multicentre study in seven ENT-clinics utilising an identical protocol. A budesonide dosage of 400 micrograms/day was used as starting dose, but the patients were at liberty to reduce the daily dose to 200 micrograms. The patients were observed at intervals up to 12 months. At the entry and follow-up visits the following parameters were recorded: rhinoscopic findings, nasal symptom scores, blood chemistry, hematology, urinalysis and determination of plasma cortisol levels before and after stimulation with ACTH (Synacthen). Nasal biopsies taken from 50 of the patients at the beginning and completion of the study were examined in a blinded way by an independent pathologist. The analysis revealed no histopathological changes of the nasal mucosa. At rhinoscopy no signs of atrophy or candida were reported. Lividity of the nasal mucosa was significantly reduced during the trial, which was also the case for nasal congestion and secretion. All nasal symptom parameters assessed by the patients were significantly reduced from baseline during the follow-up period. No clinically significant changes in the hematological and blood chemistry parameters were observed. Plasma cortisol analysis before and after challenge with ACTH revealed no influence on the hypothalamic pituitary adrenal axis. No tachyphylaxis was observed; on the contrary, there was a clear tendency for reduction of the daily dose of budesonide necessary to keep the patients symptom-free.(ABSTRACT TRUNCATED AT 250 WORDS)

Administration, Intranasal↗

PubMed1986

Balanced physiological saline in the treatment of chronic rhinitis.

The effects of a special balanced physiological saline on nasal symptoms of 93 patients with chronic rhinitis were studied. The main diagnoses of the patients were allergic rhinitis, atrophic rhinitis and ozaena, rhinitis sicca, chronic sinusitis, nasal polyposis and postoperative condition after nasal surgery. The tested solution was administered by a simple metered dose pump. 85 (91%) of the patients reported beneficial effects of the tested solution on nasal symptoms. In addition, 22 (71%) of those patients who used continuous anti-allergic medication, mainly intranasal steroids, reported that the tested solution improved the efficacy of their ordinary drug. So the tested solution proved to be beneficial in humidifying atrophic or otherwise dry mucosa, douching crusty nose and as adjuvant therapy in the treatment of allergic rhinitis.

Adolescent↗

PubMed1983

Two-dose beclomethasone dipropionate aerosol in the treatment of seasonal allergic rhinitis.

Seventy patients with seasonal allergic rhinitis and with positive skin test to birch pollen were treated during the birch pollen season for three weeks in a randomized, double-blind placebo controlled, multicenter study. Nineteen patients were treated with beclomethasone dipropionate aerosol (50 micrograms/puff) one puff per nostril X 4 (daily dose 400 micrograms), 20 patients with beclomethasone dipropionate aerosol two puffs per nostril X 2 (daily dose 400 micrograms), 15 patients with placebo one puff per nostril X 4, and 16 patients with placebo two puffs per nostril X 2. Efficacy of the therapy was assessed through rhinoscopy (swelling and secretion of the mucous membrane) and measuring the nasal peak expiratory flow (NPEF) before, during and at the end of the trial. Nasal symptoms and the use of antihistamine tablets were recorded for five days before the trial and daily throughout the trial. Atmospheric pollen concentrations were recorded daily and the treatment was started two days after the air pollen counts had exceeded 10/m3. The severity of the nasal symptoms was compared in the statistical analysis before the trial, during the pollen season without treatment and at the time of peak pollen counts during the treatment. Both active regimens controlled the symptoms effectively (p less than 0.01) and both placebos showed no significant effect on the symptoms. In rhinoscopy, both active drugs reduced the swelling of the mucous membrane and the difference was significant (p less than 0.05). No statistical differences were found in the NPEF or in the use of antihistamine tablets between the four groups. In conclusion this study showed that two-dose beclomethasone dipropionate with a daily dose of 400 micrograms is effective in the treatment of seasonal allergic rhinitis.

Administration, Intranasal↗

PubMed1979

Abscess tonsillectomy à tiède.

During recent years, primary tonsillectomy, tonsillectomy à chaud, has again become popular as the standard therapy for the peritonsillar abscess, whereas the traditional tonsillectomy à froid, made 4--6 weeks after the incision, has been partially eclipsed. It seems, however, that the intermediate form between these two, tonsillectomy à tiède, an abscess tonsillectomy made 3--4 days after the incision, would be highly practical in many cases, compared with the other two mentioned above. The tonsillectomy à chaud requires such a high state of readiness for anaesthesia, even during the emergency hours, that it is not practical in all otolaryngological departments. Tonsillectomy à tiède needs a longer hospitalization, yet requires fewer days off work than does the classical tonsillectomy à froid method. Furthermore, a significant proportion of the patients fail to present themselves for tonsillectomy at the agreed time and consequently get a recurrence of the disease later on. Tonsillectomy à tiède is almost as easy an operation as the normal tonsillectomy, both for the surgeon as for the patient. During the years 1976--77, 153 cases of peritonsillar abscess were seen. 105 cases were treated with the tonsillectomy à tiède method. The average duration of treatment was 6 1/2 days. The only complications were 6 cases of light secondary bleeding. A tonsillectomy à chaud was performed on 9 children in the age group 3--9 years.

Adolescent↗