Biomedical subjects

P Roy

Publications and source records attributed to P Roy.

474 records · Page 27Linked to original sources

PubMedDate not supplied

[Gastric acid secretion in children with duodenal ulcer].

Gastric acid secretion was studied in 17 children with primary duodenal ulcer (mean age: 10 yrs 4 mo, rang: 4-16). Eight of the 17 children with primary ulcer had chronic evolution and 10 of them had an affected first degree relative. Basal acid output (BAO) and peak acid output under pentagastrin (PAO) were not significantly different in the 17 children (0.094 +/- 0.085 mmol/kg/hr; 0.483 +/- 0.235 mmol/kg/hr) and in 32 adults with duodenal ulcer (0.073 +/- 0.010 mmol/kg/hr; 0.477 +/- 0.021 mmol/kg/hr). BAO and PAO were not significantly different between children with or without chronic ulcer. The BAO and PAO of children with an affected first degree relative were significantly higher than those of children without (p less than 0.05). This study shows that gastric acid secretions are similar in children and adults with duodenal ulcer. The chronicity of duodenal ulcer in childhood is not associated with increased acid secretion. Gastric acid secretion seems to be higher in children with an affected first degree relative than those without.

Adolescent↗

PubMedDate not supplied

[The compression syndrome: A revaluation of the value of postural angiography (author's transl)].

A total of 136 patients with a compression syndrome of the upper limb were examined systematically by selective dynamic angiography as developed by the Hôtel-Dieu Hospital in Montreal. The method consists of given multiple injections of a contrast medium with the patient's arm in thirteen different positions. This retrospective study demonstrated that this method carries very little risk and is well-tolerated by the patients. Conclusions are drawn from a comparative statistical analysis of the angiographic results and the therapy chosen. The practical value of the examination is not to confirm the anatomical site of the compression but to evaluate the characteristics of the stenosis before a decision is made whether to operate. In this respect, the positions in which the patient is sitting down and the arm is in abduction are those in which a difference is found between those patients operated upon and those given medical treatment, which is a point in favour of this particular procedure.

Adolescent↗

PubMedDate not supplied

[Health care patterns and colorectal cancers. Study in the population of the Côte d'Or between 1976 and 1990].

OBJECTIVE: The goal of this study was to analyze the characteristics of colorectal cancer patients associated with the distribution of the incident cases in the health care pattern (public, private and mixed health care options) and to study the development of this distribution over time. METHODS: The study concerned 3,403 cases of colorectal cancer diagnosed in the Côte-d'Or region, France between 1976 and 1990. The relationship between patient characteristics and the type of health care pattern was analyzed using a polychotomous logistic regression model. RESULTS: Data analysis indicates an uneven patient distribution among the public (40.6%), private (47.3%) and mixed (12.1%) sectors. The proportion of patients received in the public sector increased with the age of the patient with a proportional decrease in private and mixed sectors: compared with patients under 65 years cared for in the public sector, the odds ratio characteristic of the private sector was 0.74 for the age group 65-74 and 0.44 for those over 74 years. The odds ratios characteristic of the mixed sector were 0.71 and 0.41 respectively. Cases demonstrating symptoms received care more often in the private sector (48.3%) than in the public (38.7%) or mixed (13%) sectors, whereas those diagnosed in patients with no digestive disorders as well as those diagnosed in emergency situations were mainly cared for in the public sector. Cancers in advanced stages were more often treated in the public sector. In the case of palliative treatment, the patients were more often treated in the public sector than in the private sector or mixed sector. This phenomenon was more marked in the case of symptomatic treatments: with curative treatment taken as the category of reference, the odds ratios associated with symptomatic treatment were 0.38 for the private sector and 0.18 for the mixed sector. Over the period of time examined, there was an increase in the proportion of patients receiving care in the private sector when they lived in the area serviced by Dijon or in areas without a health "structure". Patients residing in areas with a general hospital unchanged over time. Relatively disadvantaged social categories were more often associated with care in the public sector. CONCLUSIONS: This study shows that the characteristics of colorectal cancer patients differ between the public and private sectors. It shows the differences in recruitment of health care structures according to the treatment of those patients. The study provides information useful in conceiving regional schemes of health care organisation.

Aged↗

PubMedDate not supplied

Urinary excretion of nitrosamino acids and nitrate by inhabitants of high- and low-risk areas for nasopharyngeal carcinoma in southern China.

The hypothesis that endogenous synthesis of nitrosamines from dietary precursors is a risk factor for nasopharyngeal carcinoma (NPC) in China was tested by applying the nitrosoproline (NPRO) test to subjects living in high- and low-risk districts for NPC in Zangwu county, Guangxi region, in southern China. Samples of 12-h urine were collected from 77 subjects: (a) before any treatment; (b) after ingestion of proline; and (c) after ingestion of proline together with vitamin C. NPRO, other nitrosamino acids, and nitrate were measured as indices of exposure to preformed and endogenously formed nitrosamines or their precursors. The NPRO level after proline intake was significantly increased in subjects from the high-risk area (P = 0.012) and markedly reduced after ingestion of ascorbic acid (P = 0.007), but such an effect was not seen in subjects from the low-risk area. Levels of N-nitrosothiazolidine-4-carboxylic acid and the sum of nitrosamino acids in subjects in the high-risk area were significantly reduced by ascorbic acid (P < 0.01) but were not reduced in subjects from the low-risk area. The urinary nitrate level was about twice as high in subjects from the high-risk area. In subjects from high- and low-risk areas combined, NPRO levels in any of the three dose groups were highly correlated with nitrate levels (P = 0.0001). These results demonstrate a higher potential for endogenous nitrosation in subjects living in the high-risk area of NPC and suggest the occurrence of nitrosation inhibitors in the diet consumed in the low-risk area.(ABSTRACT TRUNCATED AT 250 WORDS)

Animals↗

PubMedDate not supplied

Abdominal tuberculosis. Diagnosis by fine needle aspiration cytology.

One hundred five cases of tuberculosis of the abdomen (excluding genitourinary involvement) diagnosed initially by fine needle aspiration cytology between 1988 and 1991 were analyzed retrospectively. The diagnosis of tuberculosis was suspected clinically in 60% of the cases prior to aspiration. The anatomic locations of the lesions were ileocecal in 69 cases, lymph node in 18, colon in 10, jejunoileal in 2, duodenojejunal in 1, peritoneal in 1 and liver in 4. Cytomorphologic analysis of the aspirates from these 105 cases showed only necrotic material in 19 cases, necrotic material with epithelioid granuloma in 36 cases and epithelioid granuloma without necrosis in 50 cases. Ziehl-Neelsen staining for acid-fast bacilli was positive in 47 of 105 cases (45%). Cultures for mycobacteria were positive in 5 of 24 cases. Histologic confirmation was available in five cases only. The cytodiagnosis correlated well with the radiologic findings and response to antituberculosis chemotherapy.

Abdomen↗

PubMedDate not supplied

Helicobacter pylori infection in patients with perforated duodenal ulcer.

AIM: Perforation is the commonest complication of duodenal ulcer. Helicobacter pylori is found in 95% patients with duodenal ulcer. However, there is paucity of reports on prevalence of H. pylori infection in patients with duodenal ulcer perforation. We, therefore compared the incidence of H. pylori infection in patients with duodenal ulcer perforation with the incidence in patients having complicated duodenal ulcers and non-ulcer dyspepsia. PATIENTS AND METHODS: The study was conducted on 45 patients (complicated duodenal ulcer 15, duodenal ulcer perforation 15, non-ulcer dyspepsia 15). Per-operative punch antral biopsies were taken in patients with duodenal ulcer perforation whereas endoscopic punch biopsies of antrum were taken in patients with non-ulcer dyspepsia. The criteria for H. pylori positivity was i) growth of H. pylori on culture, ii) combination of rapid urease test (RUT) and Giemsa staining, combination of RUT and Gram stain being positive for H. pylori. RESULTS: While 9 of 15 cases with complicated duodenal ulcer, 7 of 15 cases with non-ulcer dyspepsia were positive for H. pylori, none of the patients with duodenal ulcer perforation tested positive for H. pylori (p < 0.000). All patients with perforated duodenal ulcer had histological gastritis (H. pylori -ve). Fourteen of 15 patients (9 H. pylori +ve, 5 H. pylori -ve) with complicated duodenal ulcer and 9 of 15 patients (7 H. pylori +ve) with non-ulcer dyspepsia had histological gastritis. CONCLUSION: Patients with duodenal ulcer perforation do not have H. pylori infection. H. pylori negative patients of duodenal ulcer may have more predilection for perforation.

Adolescent↗