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Biomedical subjects

P Romano

Publications and source records attributed to P Romano.

172 records · Page 10Linked to original sources
PubMedDate not supplied

Primary pulmonary hypertension.

Primary pulmonary hypertension (PPH) is a condition characterized by sustained elevation of pulmonary artery pressure (PAP) without demonstrable cause. The most common symptom at presentation is dyspnea. Other complaints include fatigue, chest pain, syncope, leg edema, and palpitations. Right heart catheterization is diagnostic, showing a mean PAP >25 mmHg at rest and >30 mmHg during exercise, with a normal pulmonary capillary wedge pressure. In the National Institutes of Health-PPH registry, the median survival period was 2.8 years. Treatment is aimed at lowering PAP, increasing cardiac output, and decreasing in situ thrombosis. Vasodilators have been used with some success in the treatment of PPH. They include prostacyclin, calcium-channel blockers, nitric oxide and adenosine. Anticoagulation has also been advised for the prevention of deep vein thrombosis, pulmonary embolism, and in situ thromboses of the lungs. New drug treatments under investigation include L-arginine, plasma endothelin-I, and bosentan. Use of oxygen, digoxin, and diuretics for symptomatic relief have also been recommended. Patients with severe PPH refractory to medical management should be considered for surgery.

Female↗
PubMedDate not supplied

An experimental study to examine the patency and tissue response of two types of biosynthetic graft used as a replacement for porcine inferior vena cava.

This experimental study has been carried out to evaluate biosynthetic grafts as vascular substitutes. Tubular segments of 35 x 8 mm made of (1) tanned ovine collagen and integral polyester mesh, either of the first (Omniflow I) or second generation (Omniflow II), or (2) polytetrafluoroethylene (e-PTFE), have been sutured in the infrarenal inferior vena cava of pigs, and removed 1 hour, 7, 14, 28, 56 and 112 days after implantation. The patency rate of biosynthetic grafts was higher than that of e-PTFE grafts (p < 0.01). There was no significant difference between the patency of the first generation and second generation collagen grafts. These results indicate that biosynthetic prostheses may be suitable vascular substitutes in low flow and low pressure systems. Improvements in the collagen inner cover structure (Omniflow II vs. Omniflow I), producing greater mechanical endurance, did not enhance long-term patency or the healing patterns of biosynthetic grafts.

Animals↗
PubMedDate not supplied

Long-term results of surgery for the treatment of sustentacular fractures of the calcaneus.

The authors reviewed 55 sustentacular fractures of the calcaneus treated between 1979 and 1988. Our therapeutic objective was that of reconstructing the subtalar joint. This purpose was always achieved in a short amount of time; nonetheless, there were some cases of secondary unreduction in time (13% poor results in 4.5 years). Essex-Lopresti closed surgery was used to treat fractures with limited damage of the joint surface; open osteosynthesis with associated grafting was used to treat fractures with more than one fragment.

Adolescent↗
PubMedDate not supplied

Long-term results of intersomatic lumbar fusion with a posterior approach.

The authors discuss the advantages of using intersomatic lumbar fusion with a posterior approach for the treatment of low back pain due to discopathy or grade I spondylolisthesis. After a description of the surgical method used, the long-term results obtained in 16 cases are presented. The clinical and radiographic results are good in cases of discopathy, while in those of spondylolisthesis there is disagreement between the clinical evaluation, which is generally satisfactory, and the radiographic evaluation which is not quite as satisfactory.

Adult↗
PubMedDate not supplied

[Clinico-morphologic correlations of lesions induced by adriamycin administered in the thoracic aorta].

The Authors, on the basis of 9 casual radiographic observations of thoracic aortic ectasy in subjects affected of neoplasms and previously treated with antitumoral drugs, hypothesize a possible correlation between the use of adriamycin and the appearance of the aortic lesion. So, they suggest an experimental study on 12 rabbits. They administered adriamycin 2 mg/kg twice weekly for 5 weeks to 8 rabbits. The other 4 rabbits are considered as control group. After 24 hours from the end of treatment the Authors sacrifice 4 treated rabbits and 2 controls, and they examine the heart and the thoracoabdominal aorta. This procedure is repeated at 21th day in the other 4 treated rabbits and in the controls. The histopathological examinations show in the treated group the appearance of lesions especially in the media. These lesions are the elastic fragmentation, the medionecrosis and the cystic necrosis, they can be responsible of aortic ectasy.

Aged↗
PubMedDate not supplied

[Small skin surgery in children: skin analgesia with a cream made of lidocaine and prilocaine].

The problems arising daily in the management of many skin diseases as the removal of warts, molluscum contagiosum, etc. are often complicated simply by the fear of the pain of some treatment modalities (i.e., cryosurgery, curettage, etc.). A choice between no analgesia and analgesia by the classic percutaneous infiltration with local anaesthetics is sometimes difficult. A new lidocaine/prilocaine cream provides us an effective local anaesthesia for such treatments.

Administration, Topical↗