[Value of large-dose immunoglobulin therapy in cervicofacial oncology].
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Biomedical subjects
Publications and source records attributed to P Romanet.
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Chemodectomas in the carotid fork are rare and usually benign tumours. Their removal by surgery creates certain problems in terms of operating technique since they are, anatomically, awkwardly situated. An additional problem arises from loss of blood resulting from their removal and possible cardiac disturbance which might affect the functioning of the carotid sinus should the tumours have been situated in this region. Furthermore, the possible eventuality of having to clamp the internal carotid for a short or even long time, should the operation require it, presupposes a perfect knowledge of the patient's cerebral circulation. Hence, therefore, the necessity of a verification of this circulation by centrolateral carotid arteriography to confirm the permeability of the circle of Willis and a potentially good supply of blood when the blood in the region of the tumour is restricted. It is equally necessary to have a complete record of the general state of the patient's cardiovascular, circulatory, respiratory, renal and neurological conditions. These must, within certain limits, be deemed satisfactory before the decision to operate is taken. Indeed, it is these conditions that will determine the per-operative as well as the post-operative condition of the patient.
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The authors propound five personal clinical cases of intra-thyroid metastases from epithelial carcinomas. Looking through the world literature, they found 134 other such cases. Analyzing these cases, there is a marked preponderance of renal cancers. The other most frequency primary cancers are of the breast, tract, lungs and skin epitheliomas. Undeclared metastases discovered at autopsy seem to be much more frequency (approximately 7.7% of those who die of their cancer have such metastases). This discrepancy between the rarity of clinical metastases and the frequency of microscopic metastases is explained by their very great latency and their very slow progress. This justifies the attempt at a curative treatment every time this is possible: surgery plus cobalt therapy. This can produce a fairly long survival rate: one year and four months on average when the metastasis is discovered before the primary cancer; two years and then months when the metastasis is discovered after.
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