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Biomedical subjects

P Rolny

Publications and source records attributed to P Rolny.

51 records · Page 3Linked to original sources
PubMed1979

Effect of secretin and cholecystokinin-pancreozymin on plasma CEA concentration in patients with pancreatic carcinoma and pancreatitis.

Plasma CEA concentration before and after administration of secretin and cholecystokinin-pancreozymin has been determined in 89 patients with neoplastic or inflammatory pancreatric disease and other neoplastic and nonneoplastic disorders. The purpose of the study was to expore the specificity and sensitivity of such a provocation tests. Some rise of the plasma CEA concentration after hormonal stimulation could be observed in several patients in the various groups. However, none of the 37 patients with nonpancreatic disease who had a basal CEA concentration of 6 micrograms/l or less had a maximal CEA concentration above 13 micrograms/l after the stimulation whereas 7 out of 31 patients with pancreatic disease (3 with pancreatic carcinoma and 4 with chronic pancreatitis) showed such an elevation of plasma CEA concentration. Thus, the provocation test showed a satisfactory specificity for pancreatic disease but a low sensitivity. It is suggested that the possibility of an effect of physiologically released gastrointestinal hormones should be considered when "unexplained" high CEA values are found in plasma samples from nonfasting patients.

Animals↗
PubMed1979

Clinical significance of duodenal diverticula and value of hypotonic duodenography.

In 24 patients duodenal diverticula were found by means of hypotonic duodenography. Nineteen of these patients had also undergone a conventional barium examination, but with that procedure the diverticula were revealed in only 8 of them. The clinical significance of duodenal diverticula is suggested and the diagnostic value of hypotonic duodenography is emphasized.

Adult↗
PubMed1979

Premalignant lesions of the pappilla of Vater and the common bile duct.

Two patients with benign adenomatous papilloma of the papilla of Vater and the common bile duct are presented. Both patients had symptoms from the upper gastrointestinal tract and biliary system. The clinical and roentgenological aspects are discussed and the importance of the correct preoperative and/or peroperative diagnosis and the value of radical surgery is emphasized.

Aged↗
PubMed1978

The secretin-CCK test and a modified Lundh test. A comparative study.

A comparison has been made between a modified Lundh test and the secretin-CCK test. Thirty-four patients with pancreatic disease (chronic pancreatitis, n = 25; recurrent pancreatitis, n = 5; and pancreatic carcinoma, n = 4) and 20 patients with other gastrointestinal disorders were studied. The results showed that estimation of trypsin secretion, irrespective of the mode of stimulation, had a low sensitivity in detecting pancreatic disease. Estimation of bicarbonate secretion after secretin stimulation provided a more sensitive test, especially for disclosing chronic pancreatitis.

Adult↗
PubMed1978

A comparative evaluation of endoscopic retrograde pancreatography and secretin-CCK test in the diagnosis of pancreatic disease.

The purpose of this study was to compare the diagnostic efficacy of endoscopic retrograde pancreatography (ERP) and secretin-CCK test for the diagnosis of pancreatic disease. The bicarbonate output after the secretin stimulation was low in 26 out of 30 patients (87%) with pancreatitis, whereas ERP revealed an abnormal duct in 21 (70%) of these patients. In all 7 patients with pancreatic carcinoma, ERP showed major abnormalities, whereas the bicarbonate output was reduced only in four of them. Thus, the secretin test appears to be at least as efficient as the ERP in disclosing pancreatitis. On the other hand, ERP seems to be a more reliable method for the diagnosis of pancreatic carcinoma.

Adult↗
PubMed1978

Diagnostic value of hypotonic duodenography in superior mesenteric artery syndrome.

The superior mesenteric artery syndrome is a compression of the duodenum. We believe that the diagnostic limitations of the routine barium meal studies can be abolished by hypotonic duodenography. Before surgical treatment other pathological conditions should be excluded. Peptic ulcer disease often coexists. Patients with persisting signs and symptoms after surgery for ulcer should be re-examined with this condition in mind. The adequate treatment is duodenojejunostomy.

Adult↗
PubMed1977

The CEA concentration in duodenal fluid in patients with pancreatic disease.

The CEA concentration in duodenal fluid after secretin-CCK stimulation has been investigated in 16 patients with pancreatic disease (6 with pancreatic carcinoma and 10 with chronic pancreatitis), 9 with non-pancreatic disease, and 10 control subjects. The purpose was to study whether the determination of CEA in duodenal fluid during the secretin-CCK test can give any additional information for the diagnosis of pancreatic disease and for differentiation between pancreatitis and carcinoma. We found that high values of CEA in duodenal fluid do not necessarily indicate pancreatic carcinoma. Moreover, the level may be elevated in non-pancreatic disease.

Carcinoembryonic Antigen↗
PubMedDate not supplied

Post-cholecystectomy patients with "objective signs" of partial bile outflow obstruction: clinical characteristics, sphincter of Oddi manometry findings, and results of therapy.

Seventeen patients, 15 women and 2 men with upper abdominal pain categorized to biliary group I suspected sphincter of Oddi dysfunction, underwent thorough clinical evaluation including ERCP and endoscopic sphincter of Oddi manometry. All the patients were subsequently treated by endoscopic (n = 15) or surgical (n = 2) sphincterotomy. The mean age of patients studied was 62 years. They all had cholecystectomy several years previously (median, 18 years). At ERCP all patients showed a large common bile duct dilation (mean diameter, 18 mm) and delayed contrast drainage greater than 45 minutes. Sphincter of Oddi manometry, although abnormal in most patients, revealed normal sphincter of Oddi pressure in six patients (35%). Nonetheless, sphincterotomy resulted in relief of symptoms in all (mean follow-up, 28 months; range, 3 to 46 months), thus suggesting that their pain was indeed caused by the disordered sphincter of Oddi. These findings support the previous assumption that in symptomatic post-cholecystectomy patients the triad of elevated liver function tests, dilated common bile duct, and delayed contrast drainage at endoscopic retrograde cholangiopancreatography indicates a definitive sphincter of Oddi abnormality. The normal sphincter of Oddi pressures in many of these patients are probably due to a different, noncompliant type of sphincter of Oddi dysfunction. Because these patients invariably benefit from sphincterotomy, sphincter of Oddi manometry in this category is not only unnecessary, but it may also be misleading.

Adult↗