[Effect of thyroid hormones on mitochondrial DNA-polymerase activity].
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Age Factors↗
Biomedical subjects
P Rocco
Publications and source records attributed to P Rocco.
Prophylactic sclerotherapy of high-risk esophageal varices: results of a multicentric prospective controlled trial.
In this prospective, multicenter trial, 140 cirrhotic patients with no previous upper gastrointestinal bleeding and with esophageal varices endoscopically judged to be at high risk of hemorrhage were randomized to receive either sclerotherapy or conservative treatment for the prevention of first variceal bleeding. The end-points of the study were bleeding and death. Life table curves showed that prophylactic sclerotherapy significantly diminished the incidence of variceal hemorrhage (p less than 0.001) and overall mortality (p less than 0.01). Two-year cumulative bleeding rate was 18% in the sclerosis group (95% confidence interval = 10 and 31) and 57% (95% confidence interval = 40 and 72) in the control group. Two-year cumulative mortality rate was 30% (95% confidence interval = 19 and 45) in the sclerotherapy group and 56% (95% confidence interval = 39 and 72) in the controls. One patient died after hemorrhage from an ulcer secondary to sclerotherapy. Analysis by the Cox model of the factors potentially confounding or interacting with the effect of sclerotherapy suggested that sclerotherapy was more efficient in preventing first bleeding in patients with decompensated disease (Child B and C) than in those in good condition (Child A). However, the 2-year cumulative bleeding rate of untreated Child A patients was only 19%, showing how in this group the endoscopic findings were unreliable in selecting high-risk varices and explaining why after a 2-year follow-up prophylactic sclerosis did not show any benefit in such patients. We conclude that sclerotherapy can decrease the incidence of first variceal bleeding and death for a period of 2 years in cirrhotic patients with high-risk varices.
Adult↗
[Local recurrence of breast cancer].
The Authors analyse the prognostic value of the breast cancer local recurrence which not influence survival. For this reason the surgical treatment sometime can be conservative like the first treatment.
Breast Neoplasms↗
Thermographic evaluation of myocardial cooling and intraoperative control of graft patency in patients with coronary artery disease.
Intraoperative thermographic evaluation of regional myocardial cooling induced by cardioplegia, in patients with coronary artery disease, was conducted in 22 cases. Pictures were obtained at the beginning of the cardiopulmonary by-pass, after general cooling and during cardioplegic infusion. Uneven myocardial cooling was observed related to the degree of coronary artery stenosis. After the distal anastomosis of the saphenous vein by-pass graft was completed, injection of cold solution in to the graft showed marked cooling of the dependent myocardium, proving the patency of the graft. In the case of internal mammary artery graft (IMA), after the anastomosis was completed, releasing the bull-dog clamp on the IMA graft, allowed a flow of relatively warm (30 degrees C) blood in the anterolateral wall of the cold (20 degrees C) heart. A warm spot appeared in the thermographic pictures, assessing the patency of the IMA graft. Thermography appears to be a useful tool during myocardial revascularization in order to assess proper myocardial cooling during cardioplegia, and to check intraoperative patency of saphenous vein graft and IMA graft. The use of a special mirror prevents interference with the surgeon's work.
Coronary Disease↗
Correlations between Doppler, thermography and ophthalmodynamometry for instrumental dépistage of cerebral vasculopathy.
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Cerebrovascular Disorders↗
[Transposition of the myocutaneous flap of the latissimus muscle of the back in reconstruction of the breast after radical mastectomy. Indications and technic studied in 2 operated cases].
For repair of radical mastectomy defects the surgical approach with the latissimus dorsi myocutaneous flap is presented. The application of this flap and complication are described. In addition 2 cases are presented illustrating a personal modification of the technics.
Breast↗
[Burkitt lymphoma].
The Authors report a case of Burkitt's lymphoma of the stomach in a patient treated ten years before for Hodgkin's lymphoma. Gastrectomy associated to chemotherapy is more effective than surgical treatment alone and avoids the risk of gastric perforation during medical treatment.
Adult↗
[Seminoma and adrenogenital syndrome].
The Authors report a case of a 26 year old patient affected by adrenogenital syndrome, likely due to 21 hydroxylase defect, hermaphroditism (46XX genotype and female phenotype) and worked hyperandrogenism; moreover a hidden testis neoplasm (seminoma) was associated.
Adrenal Hyperplasia, Congenital↗