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Biomedical subjects

P Robson

Publications and source records attributed to P Robson.

At least 55 records · Page 3Linked to original sources
PubMed1983

Studies on the metabolism of the new anti-hypertensive agent, indoramin, in man.

The absorption, metabolism and excretion of the new antihypertensive agent indoramin (Baratol) have been studied in male volunteers following oral administration of the drug labelled either with 14C or with tritium. Absorption of the drug proceeded at moderate rate, peak plasma radioactivity levels being seen by 3 h after dosing. Metabolism was extensive as shown by very little unchanged compound appearing in urine. Two major urinary metabolites accounting for some 35-40% of the renally excreted material were identified as acid labile conjugates of indoramin itself and indole 6-hydroxylated indoramin. The pattern of biotransformation appeared to be similar to that in the patas monkey, the species used in the long term safety evaluation of the drug. Excretion of the drug and metabolites occurred primarily via the faeces which accounted for 49.7 +/- 4.9% of the dose. A further 31.7 +/- 2.4% was recovered in the urine. Renal elimination of total radioactivity occurred in an apparently monoexponential manner with a half-life of 11.9 +/- 1.2 h.

Adult↗
PubMed1982

The use of meptazinol as a premedication for surgical patients.

The acceptability of a mixture of meptazinol and hyoscine as a surgical premedication was compared with that of an Omnopon-hyoscine combination in a randomized, double-blind trial involving 101 surgical patients. Blood pressure and respiratory rate were significantly reduced to a similar extent by both premedicant combinations, and this may be interpreted as evidence of a satisfactory alleviation of anxiety by both test mixtures. The two mixtures produced a similar degree of sedation, and both were associated with a useful inhibition of salivary secretion. Side-effects were reported in 25% patients in the meptazinol group, and in 28% of those receiving Omnopon, although a number of these effects may be attributable to hyoscine. There was no difference in the pattern of post-operative analgesic requirements between the two groups, and no unfavourable interaction was noted with any of the anaesthetic agents used.

Adolescent↗
PubMed1981

The hazards of rehabilitation.

Falls are the most common accident occurring to patients in hospital, especially those undergoing rehabilitation. The types, causes, and consequences of such falls are discussed in relation to the patients' age and underlying condition with reference to 386 accidents occurring over a 5-month period in a hospital with 50% geriatric beds. Measures that may reduce the hazard to the patient and minimise the risk of accidents in hospital are suggested.

Accident Prevention↗
PubMed1980

The study of stroke.

Explore the source record for details and available documents.

Cerebrovascular Disorders↗