Search PubMed⌕ Search

Biomedical subjects

P Robert

Publications and source records attributed to P Robert.

122 records · Page 7Linked to original sources
PubMedDate not supplied

[Biological indices in schizo-affective disorders].

Besides the well-defined nosological groups such as schizophrenia and affective disorders, the so-called schizoaffective disorders remain in an intermediate position. Biological features tend to build up links between these two disorders and support the hypothesis of a biological continuum between schizophrenia and affective disorders. Among these biological factors, neuroendocrinology, brain neurotransmission and sleep seem to be particularly relevant. This "continuum" hypothesis may also be supported by therapeutical and epidemiological data.

Amino Acids↗
PubMedDate not supplied

[Circadian rhythms of the central temperature and blood cortisol in endogenous depression].

Beside neurochemical imbalances, there are numerous disruptions of circadian rhythms in endogenous depression. Recent studies have actually shown instability in rhythmicity and phase advance of many circadian rhythms in depression (central temperature, cortisol, urinary MHPG...). We have observed the longitudinal evolution of circadian rhythms (core temperature, plasma cortisol) of depressed patients who were treated by a two weeks phase-advance process, then with antidepressant drugs. Our results show that clinical improvement during phase-advance process is much faster than under tricyclics, with the same Hamilton scale level after two weeks of treatment. From a biological point of view, we show an ultradian instability, a phase advance (2 to 4 hours) and modifications of averages and amplitudes of circadian rhythms. These abnormalities tend to disappear during phase-advance process and antidepressant therapy. Phase response curves to the phase shift in depressed patients could be explained by a bad sensitivity of these subjects to external synchronisers linked to an internal dyschronism. These disturbances lead us to link desynchronisation and endogenous depression.

Antidepressive Agents↗
PubMedDate not supplied

The possibility of antiidiotypic activity in multipareous mice.

CBA females pregnant of A/J males were tested for the presence in their sera of antiidiotypic antibodies, capable of combining with antipaternal Ig determinants. Radioimmunoassay tests have shown that in comparison to females pregnant of isogeneic males, allopregnant sera presented values indicating the presence of an antiidiotypic reaction in five out of seven trials. The possible role of antiidiotypic reactions in the control of maternofoetal relationship is discussed.

Animals↗