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Biomedical subjects

P Rigotti

Publications and source records attributed to P Rigotti.

79 records · Page 5Linked to original sources
PubMedDate not supplied

Treatment of lymphocele following renal transplantation by laparoscopic surgery.

We describe a new technique for internal drainage of lymphocele following renal transplantation performed by laparoscopy. After induction of the pneumoperitoneum, using the cautery hook, a wide opening in the lymphocele peritoneal wall has been performed allowing the lymph flow to enter the peritoneal cavity. A portion of the omentum has been pushed inside the lymphocele cavity and fixed to the parietal peritoneum in order to avoid closure of the peritoneal window. A postoperative CT scan control has shown the complete disappearance of the fluid collection. Internal drainage of lymphocele performed by laparoscopy allows a radical treatment with minimal trauma for the patient and has therefore potential advantages over the other current procedures.

Adult↗
PubMedDate not supplied

[Renal transplantation. 1st year's experience at a new center].

The initial activity in the field of organ transplantation always brings some organizational and medical difficulties. We describe the first year experience in the field of kidney transplantation at the Transplantation Unit of Padua University. Sixteen kidney transplants from cadaver donors have been performed. A double drug therapy (cyclosporine and steroids) as immunosuppression was used in 9 patients and a triple drug protocol (cyclosporine, steroids, azathioprine) was used in 7. Two patients also received monoclonal antibodies because of steroid resistant rejection. The technical problems we observed include one case of ureteral duplication corrected with uretero-ureteral anastomosis and one substenosis of an ureteral cystoanastomosis corrected with endoscopic dilatation. Among the complications related to immunosuppressive therapy we had one case of severe cyclosporine nephrotoxicity. Two patients died after few months with a functional graft because of pulmonary embolism and because of severe hepatitis complicated by pancreatitis. At an average of six months follow-up all the remaining patients have a good functioning graft.

Adolescent↗
PubMedDate not supplied

[Cyclosporin].

Explore the source record for details and available documents.

Cyclosporins↗
PubMedDate not supplied

Increased incidence of renal allograft thrombosis under cyclosporine immunosuppression.

Six of 325 patients undergoing renal transplantation under combined cyclosporine (CsA)-prednisone immunosuppression displayed renal artery thrombosis between 4 and 12 days after transplantation. All six patients had satisfactory initial revascularization, as ascertained by radionuclide scan and renal function. In none was the thrombosis considered to be secondary to rejection, either by clinical course or upon renal biopsy. Since there was no clear etiologic factor and since none of the overlapping 297 patients treated with azathioprine-prednisone displayed this complication, these cases appear to support the hypothesis that CsA alters intravascular hemostatic homeostasis. Data in experimental models are consistent with a predisposing factor to thrombosis, namely CsA reduces the synthesis of prostacyclin stimulating factors, leading to decreased prostacyclin production by vascular endothelial cells, and to failure to inhibit platelet aggregation.

Acute Disease↗
PubMedDate not supplied

[Aromatic and branched chain amino acids after porto-caval anastomosis: plasma and brain regional levels in the rat (author's transl)].

Automated analysis of aromatic and branched chain amino acids was performed in plasma and in four cerebral regions of rats submitted to chronic porto-caval shunt. Compared to controls, plasma of the operated animals exhibited a significant diminution of valine, leucine, isoleucine, a net increase of phenylalanine and tyrosine, with unchanged tryptophan levels. Brain valine, leucine and isoleucine were either increased or unchanged, whereas an enormous increase of aromatic amino acids, uniform in the four cerebral regions, was observed. The lack of correlation between plasmatic and cerebral levels of these essential amino acids leads to the hypothesis that cerebral permeability to amino acids is modified after experimental portocaval anatomosis: we recent confirmed that blood-brain mediated transport of the neutral amino acids is increased in this condition. A slower cerebral turnover of these metabolites could also contribute to elevate their cerebral concentrations after portocaval shunt.

Amino Acids↗
PubMedDate not supplied

[In vivo aminoacid transport in the brain of the rat with porto-caval anastomosis (author's transl)].

Cerebral capillary permeability to L-amino acids was studied in rats submitted to porto-caval anastomosis 4 weeks before. The short-term intracarotidal injection technique described by Oldendorf was used throughout. Neutral amino acid permeability appeared to be greatly increased, the most important enhancement being for the tryptophan. On the opposite, basic amino acids showed a net decrease in their rate of passage from blood to the brain. No changes were observed for GABA and glutamic acid. These data suggest a marked modification of the permeability of the cerebral capillary membranes in the rat with chronic portocaval anastomosis. Moreover, such alterations are selective for the different amino acid transport classes. Competitive inhibition decreased the permeability of methionine at the same level in both control and experimental animals: therefore, the neutral amino acid increased entry into the rat brain after porto-caval shunt is due to an enhancement of the transport processes.

Amino Acids↗