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Biomedical subjects

P Reinert

Publications and source records attributed to P Reinert.

At least 127 records · Page 7Linked to original sources
PubMed1983

Clinical value of the determination of an interferon-induced enzyme activity: studies of the 2'5' oligoadenylate synthetase activity in peripheral blood lymphocytes of patients.

The 2'5' oligoadenylate synthetase (2'5' A synthetase) is one of the interferon-induced enzymes. The measurement of its activity may thus reveal the presence of interferon, which is one of the body's non-specific antiviral, antitumor, and immunoregulatory agents. We found a constant level of this enzyme activity (mean value: 0.31 units +/- 0.13 S. D.) when measured in the white blood cells of healthy subjects (104). The majority of the patients with viral (27/30), bacterial (13/16) and autoimmune (15/16) diseases showed a 2'5' A synthetase activity greater than 0.57 units (mean value of the control + S. D.). Conversely the 2'5' A synthetase activity level was normal or low in malignancies and in diseases depending on other aetiologies than those described above. Therefore this simple an rapid biochemical assay seems to be useful for clinical study of infectious and inflammatory diseases.

2',5'-Oligoadenylate Synthetase↗
PubMed1983

[Facial lupus vulgaris caused by BCG].

The authors report on an exceptional complication of BCG vaccination: a case of facial lupus vulgaris, which appeared one year after vaccination in a girl with normal cellular and humoral immunity.

Antibiotics, Antitubercular↗
PubMed1981

A classification system to meet today's needs.

Patient classification systems hold the promise of providing nursing services with objective and scientific means to identify acuity levels and project staffing requirements. Nursing administrators have an obligation to base nurse staffing on objective documentation. To ensure the cooperation of nursing staff, they must make the classification system meaningful to staff and patient care goals. A classification system based on accurate and objective assessment of patient acuity levels will enable administrators to use their most valuable resource--their nursing staff--efficiently and effectively.

Classification↗
PubMed1981

[Varicella and herpes zoster in 83 children treated for malignancies (author's transl)].

57 children treated for malignant diseases presented with varicella and 26 with herpes zoster. Evolution of varicella was benign in 33 children but was complicated in 24, resulting in the death of 6 children. No child died of herpes zoster. The severity of skin and lung symptoms was of no prognostic value but digestive symptoms were associated with severe forms of the disease. Immuno-stimulation was of no use. Vidarabine did not improve the death rate; acycloguanosine is currently under study.

Adolescent↗
PubMed1981

Human dialysable leucocyte extracts (transfer factor) in interstitial pneumonia. A retrospective trial in immunodeficient patients.

Thirty-six cases of interstitial pneumonia in acquired immunodeficient states were treated with transfer factor (Dialysable Leukocyte Extract) and studied retrospectively. The criteria of efficacity of this treatment were: rapidity of immediate improvement, improvement after failure of other immunostimulant therapy and demonstration of a dose-related effect. The mechanism of the therapeutic action is unclear. There is no evidence in favour of "transfer" of cell mediated immunity. A non-specific mode of action (adjuvant effect, interferon synergy, proinflammatory action) seems much more likely.

Chickenpox↗
PubMed1980

[Intradermal reaction to phytohaemagglutinin. Value in paediatrics (author's transl)].

The existence of a deficiency in cellular immunity is common in paediatrics, and hence the need for a simple and rapid test for its evaluation. We thus studied the intradermal reaction to phytohaemagglutinin (PHA) in 690 children and sought to establish a correlation with regard to age and stimulation in vitro (PHA lymphoblastic transformation test). Normally, the injection of 5 g of purified PHA is followed 24 hours later in the child aged over 1 month by an induration more than 8 mm in diameter and erythema larger than 10 mm. These diameters then increase regularly with age up to 15 years. It was possible to establish a correlation between the intradermal reaction and blastic stimulation in vitro in 80% of cases. The intradermal reaction to PHA was found to be decreased in numerous viral infections, foetal diseases, during prolonged corticosteroid therapy, and during chemotherapy, haematological disorders and congenital immune deficiencies affecting T function.

Adolescent↗
PubMed1979

[Cytotoxic action of Pseudomonas aeruginosa hemolysin].

The cytopathic action of haemolysin of Pseudomonas aeruginosa has been studied in mouse and human leucocytes. The morphological changes suggest that haemolysin affects the molecular architecture of the cell membrane, whose permeability is increased. It does not induce non-specific stimulation of peripheral lymphocytes. Normal sera and albumin neutralize the hemolytic activity of haemolysin; this inhibition is also observed, to a les extent, on the lytic action on leucocytes. This raises the possibility that the two activities are probably associated with the same molecule.

Animals↗
PubMed1979

[Pneumococcal infections and pediatric intensive care (author's transl)].

During the period 1965 to 1978, 62 cases of severe pneumococcal infection were admitted in Saint-Vincent de Paul pediatric intensive care unit. Recovery without sequelae was observed in only 17 of 49 meningitis. 5 fulminant pneumococcal infections after splenectomy or other disorders were observed. This late condition may be preventable by vaccination.

Adolescent↗
PubMed1978

Impaired defense against vaccinia in a child with T-lymphocyte deficiency associated with inosine phosphorylase defect.

A case of progressive vaccinia associated with a profound deficiency of cellular immunity and a defect in inosine phosphorylase is described. A striking contrast was observed between humoral immunity, which showed little if any impairment, and a severe cellular defect affecting both markers and functions of T lymphocytes. The child died despite treatment with methosazone, levamisole, transfer factor, irradiated blood transfusions, and a thymus graft. An adequate serum level of antibody to vaccinia virus was obtained by transfer of specific immunoglobulins, but this failed to stop the progression of the disease. This observation suggests that host defense against vaccinia infection is mainly mediated by cellular immunity.

Animals↗
PubMed1978

[Pulmonary hemosiderosis in children. Immunologic study].

Circulating anti alveolar basement membrane antibodies have been detected by indirect immunofluorescence on lung rat in two out of five children presenting with pulmonary hemosiderosis. The two cases are reported and seem to be consistent with an auto-immune disease due to anti-basement membrane antibodies. Authors outline the presence of anti-reticulin antibodies in the two cases reported and the high level of IgE which seems a frequent finding in pulmonary hemosiderosis.

Animals↗