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Biomedical subjects

P Reid

Publications and source records attributed to P Reid.

At least 55 records · Page 3Linked to original sources
PubMed1990

Long-term experience with a totally implanted catheter system in cancer patients.

Long-term experience with totally implanted catheter systems (TICS) is limited. We retrospectively evaluated the performance and long-term complications of TICS for intravenous infusion in cancer patients; 134 systems were implanted in 128 patients. The median duration of implantation was 144 weeks with 49 systems implanted for more than one year. Complications related to surgical factors included malposition of reservoir (2%), skin perforation or wound dehiscence (1.5%) and pneumothorax (less than 1%). Complications not related to surgical factors included: drug extravasation (1.5%), mechanical malfunction (1.5%), vein thrombosis (less than 1%), clotting of the reservoir or catheter (2%), skin infection (1.5%), and sepsis (less than 1%). The total complication rate was 13%. Most complications resolved spontaneously or with medical treatment and only 6 patients (4.6%) required re-implantation of a second system. We conclude that with long-term usage of TICS, the complication rate remains low, making it a safe and viable alternative for patients requiring long-term intravenous therapy.

Adult↗
PubMed1988

Prolonged asystole during intraoperative myocardial reperfusion: an experimental study.

It has been observed in a proportion of patients, that clinically cardiac asystole persists for a prolonged period during intraoperative reperfusion. To evaluate this phenomenon, isovolumic functional indices (left ventricular [LV] balloon) and myocardial oxygen consumption (MV02) were compared in 22 canine preparations before and after two different interventions. After 45 minutes of normothermic global ischemia, (1) the control group (N = 11) was maintained on cardiopulmonary bypass with the hearts beating empty and (2) the experimental group (N = 11) was subjected to cardioplegia reperfusion at normothermia for one hour. In contradistinction to the initial hypothesis, functional recovery was better in the experimental group compared with the controls. Significant differences were observed in recovery of LV peak developed pressure (LVPDP) (controls, 66.8 +/- 7.3% [mean +/- standard error of the mean], and experimental group, 99.5 +/- 8.9%; p less than 0.05), maximum rate of rise of LV pressure (controls, 116.6 +/- 16.2%, and experimental group, 147.7 +/- 10.1; p less than 0.05), and maximum fall of LV pressure (controls, 100.3 +/- 15.8%, and experimental group, 143.1 +/- 11.5%; p less than 0.05). Correlation between LVPDP and MVO2 was also better preserved in the experimental group (controls: r = 0.15, N = 74, p = 0.18; experimental group: r = 0.47, N = 75, p less than 0.001). Values for myocardial water content and total creatine kinase in the two groups were similar. It was concluded that prolonged asystole during intraoperative reperfusion is not detrimental; on the contrary, there is enhanced functional recovery of the myocardium similar to that seen after secondary cardioplegia.

Animals↗
PubMed1979

Autosomal dominant dystrophy of the retinal pigment epithelium.

This study describes a salt-and-pepper fundus appearance in nine relatives in three generations of a single white kindred. Two of these patients also had subretinal patterned pigment figures by ophthalmoscopy. In another, fluorescein angiography showed a reticular pattern that was not apparent by ophthalmoscopy. This dystrophy was functionally benign, although the electro-oculogram ratio was abnormal in affected patients. This pigmentary dystrophy and fundus pulverulentus, reticular dystrophy of Benedikt and Werner, and pattern dystrophy of Marmor and Byers are indistinguishable. When patterned pigment figures are absent, this autosomal-dominant pigmentary dystrophy of the retinal pigment epithelium can be confused with other disorders such as congenital rubella retinopathy and drug toxicity.

Adolescent↗